Search Results - "Lynn, Savannah A"

A laser-induced mouse model of progressive retinal degeneration with central sparing displays features of parafoveal geographic atrophy by Khan, Adnan H., Soundara Pandi, Sudha Priya, Scott, Jennifer A., Sánchez-Bretaño, Aida, Lynn, Savannah A., Ratnayaka, J. Arjuna, Teeling, Jessica L., Lotery, Andrew J.

“…There are no disease-modifying treatments available for geographic atrophy (GA), the advanced form of dry age-related macular degeneration. Current murine…”
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Human equivalent doses of l-DOPA rescues retinal morphology and visual function in a murine model of albinism by Sanchez-Bretano, Aida, Keeling, Eloise, Scott, Jennifer A., Lynn, Savannah A., Soundara-Pandi, Sudha Priya, Macdonald, Sarah L., Newall, Tutte, Griffiths, Helen, Lotery, Andrew J., Ratnayaka, J. Arjuna, Self, Jay E., Lee, Helena

“…l -DOPA is deficient in the developing albino eye, resulting in abnormalities of retinal development and visual impairment. Ongoing retinal development after…”
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The complexities underlying age-related macular degeneration： could amyloid beta play an important role by Lynn, Savannah A, Keeling, Eloise, Munday, Rosie, Gabha, Gagandeep, Griffiths, Helen, Lotery, Andrew J, Ratnayaka, J Arjuna

“…e-related macular degeneration （AMD） causes irreversible loss of central vision for which there is no effective treatment. Incipient pathology is thought to…”
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An Exploratory Study Provides Insights into MMP9 and Aβ Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients by Lynn, Savannah A, Soubigou, Flavie, Dewing, Jennifer M, Smith, Amanda, Ballingall, Joanna, Sass, Thea, Nica, Isabela, Watkins, Catrin, Gupta, Bhaskar, Almuhtaseb, Hussein, Lash, Stephen C, Yuen, Ho Ming, Cree, Angela, Newman, Tracey A, Lotery, Andrew J, Ratnayaka, J Arjuna

“…Matrix metalloproteinase-9 (MMP9) and total amyloid-beta (Aβ) are prospective biomarkers of ocular ageing and retinopathy. These were quantified by ELISA in…”
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Oligomeric Aβ1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function by Lynn, Savannah A., Johnston, David A., Scott, Jenny A., Munday, Rosie, Desai, Roshni S., Keeling, Eloise, Weaterton, Ruaridh, Simpson, Alexander, Davis, Dillon, Freeman, Thomas, Chatelet, David S., Page, Anton, Cree, Angela J., Lee, Helena, Newman, Tracey A., Lotery, Andrew J., Ratnayaka, J. Arjuna

“…Alzheimer’s disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina with increasing age and in eyes of age-related macular degeneration…”
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A convenient protocol for establishing a human cell culture model of the outer retina. [version 1; peer review: 2 approved] by Lynn, Savannah A, Keeling, Eloise, Dewing, Jennifer M, Johnston, David A, Page, Anton, Cree, Angela J, Tumbarello, David A, Newman, Tracey A, Lotery, Andrew J, Ratnayaka, J. Arjuna

“…The retinal pigment epithelium (RPE) plays a key role in the pathogenesis of several blinding retinopathies. Alterations to RPE structure and function are…”
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A High Fat “Western‐style” Diet Induces AMD‐Like Features in Wildtype Mice by Keeling, Eloise, Lynn, Savannah A., Koh, Yen Min, Scott, Jenny A., Kendall, Aaron, Gatherer, Maureen, Page, Anton, Cagampang, Felino R., Lotery, Andrew J., Ratnayaka, J. Arjuna

“…Scope The intake of a “Western‐style” diet rich in fats is linked with developing retinopathies including age‐related macular degeneration (AMD). Wildtype mice…”
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The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2) by Taylor-Walker, George, Lynn, Savannah A., Keeling, Eloise, Munday, Rosie, Johnston, David A., Page, Anton, Scott, Jennifer A., Goverdhan, Srini, Lotery, Andrew J., Ratnayaka, J. Arjuna

“…Age-related Macular Degeneration (AMD) is a common, irreversible blinding condition that leads to the loss of central vision. AMD has a complex aetiology with…”
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Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE by Lynn, Savannah A, Ward, Gareth, Keeling, Eloise, Scott, Jenny A, Cree, Angela, Johnston, David A, Page, Anton, Cuan-Urquizo, Enrique, Bhaskar, Atul, Grossel, Martin C, Tumbarello, David A, Newman, Tracey A, Lotery, Andrew J, Ratnayaka, J.Arjuna

“…Graphical abstract…”
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A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus) by Hair, Kaitlyn, Macleod, Malcolm R, Sena, Emily S

“…The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether…”
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Oligomeric Aβ 1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function by Lynn, Savannah A, Johnston, David A, Scott, Jenny A, Munday, Rosie, Desai, Roshni S, Keeling, Eloise, Weaterton, Ruaridh, Simpson, Alexander, Davis, Dillon, Freeman, Thomas, Chatelet, David S, Page, Anton, Cree, Angela J, Lee, Helena, Newman, Tracey A, Lotery, Andrew J, Ratnayaka, J Arjuna

“…Alzheimer's disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina with increasing age and in eyes of age-related macular degeneration…”
Get full text