Search Results - "Lynn, Miriam A"

Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms by Lynn, David J., Benson, Saoirse C., Lynn, Miriam A., Pulendran, Bali

“…The need for highly effective vaccines that induce robust and long-lasting immunity has never been more apparent. However, for reasons that are still poorly…”
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Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection by Ryan, Feargal J, Hope, Christopher M, Masavuli, Makutiro G, Lynn, Miriam A, Mekonnen, Zelalem A, Yeow, Arthur Eng Lip, Garcia-Valtanen, Pablo, Al-Delfi, Zahraa, Gummow, Jason, Ferguson, Catherine, O'Connor, Stephanie, Reddi, Benjamin A J, Hissaria, Pravin, Shaw, David, Kok-Lim, Chuan, Gleadle, Jonathan M, Beard, Michael R, Barry, Simon C, Grubor-Bauk, Branka, Lynn, David J

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious respiratory virus which is responsible for the coronavirus disease 2019…”
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Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells by Silverman, Judith Maxwell, Clos, Joachim, Horakova, Eva, Wang, Adele Y, Wiesgigl, Martina, Kelly, Isabelle, Lynn, Miriam A, McMaster, W Robert, Foster, Leonard J, Levings, Megan K, Reiner, Neil E

“…We investigated the properties of leishmania exosomes with respect to influencing innate and adaptive immune responses. Exosomes from Leishmania donovani…”
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The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life by Lynn, Miriam A., Eden, Georgina, Ryan, Feargal J., Bensalem, Julien, Wang, Xuemin, Blake, Stephen J., Choo, Jocelyn M., Chern, Yee Tee, Sribnaia, Anastasia, James, Jane, Benson, Saoirse C., Sandeman, Lauren, Xie, Jianling, Hassiotis, Sofia, Sun, Emily W., Martin, Alyce M., Keller, Marianne D., Keating, Damien J., Sargeant, Timothy J., Proud, Christopher G., Wesselingh, Steve L., Rogers, Geraint B., Lynn, David J.

“…Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a…”
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Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation by Charitou, Theodosia, Srihari, Sriganesh, Lynn, Miriam A., Jarboui, Mohamed-Ali, Fasterius, Erik, Moldovan, Max, Shirasawa, Senji, Tsunoda, Toshiyuki, Ueffing, Marius, Xie, Jianling, Xin, Jin, Wang, Xuemin, Proud, Christopher G., Boldt, Karsten, Al-Khalili Szigyarto, Cristina, Kolch, Walter, Lynn, David J.

“…Background Activating mutations in KRAS frequently occur in colorectal cancer (CRC) patients, leading to resistance to EGFR-targeted therapies. Methods To…”
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No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines by Stevens, Natalie E, Ryan, Feargal J, Messina, Nicole L, Blake, Stephen J, Norton, Todd S, Germano, Susie, James, Jane, Eden, Georgina L, Tee, Yee C, Lynn, Miriam A, Botten, Rochelle, Barry, Simone E, Curtis, Nigel, Lynn, David J

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Diet at birth is critical for healthy growth, independent of effects on the gut microbiota by van den Elsen, Lieke J W, Rekima, Akila, Lynn, Miriam A, Isnard, Charlotte, Machado, Savannah, Divakara, Nivedithaa, Patalwala, Diana, Middleton, Alana, Stevens, Natalie, Servant, Florence, Burcelin, Remy, Lynn, David J, Verhasselt, Valerie

“…Colostrum is the first milk for a newborn. Its high content in microbiota shaping compounds and its intake at the time of gut microbiota seeding suggests…”
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Protocol to colonize gnotobiotic mice in early life and assess the impact on early life immune programming by Lynn, Miriam A., Ryan, Feargal J., Tee, Yee Chern, Lynn, David J.

“…Understanding how changes in gut microbiota in early life impact immune programming can be difficult to study due to variations in the assembly of the…”
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Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival by Lynn, Miriam A, Kindrachuk, Jason, Marr, Alexandra K, Jenssen, Håvard, Panté, Nelly, Elliott, Melissa R, Napper, Scott, Hancock, Robert E, McMaster, W Robert

“…Protozoan parasites, such as Leishmania, still pose an enormous public health problem in many countries throughout the world. Current measures are outdated and…”
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Differential quantitative proteomic profiling of Leishmania infantum and Leishmania mexicana density gradient separated membranous fractions by Lynn, Miriam A., Marr, Alexandra K., McMaster, W. Robert

“…Leishmaniasis, caused by infection with Leishmania, is a major public health concern affecting more than 20million people globally. Leishmania has a digenetic…”
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Protocol to assess the impact of early-life antibiotic exposure on murine longevity by Lynn, Miriam A., Ryan, Feargal J., Tee, Yee C., Benson, Saoirse C., Lynn, David J.

“…We present this protocol using a mouse model to assess the impact of early-life antibiotic exposure on mammalian lifespan and the composition of the gut…”
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Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti‐helminth defences by Rekima, Akila, Elsen, Lieke, Isnard, Charlotte, Smyth, Danielle J., Lynn, Miriam A., Yee, Tee, Stevens, Natalie E., Machado, Savannah, Divakara, Nivedithaa, Bhasin, Maheshwar, Tjiam, M. Christian, Rowel, Candia, Servant, Florence, Burcelin, Remy, Locksley, Richard, Maizels, Rick, Lynn, David J., Egwang, Thomas, Verhasselt, Valérie

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Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice by Stevens, Natalie E., van Wolfswinkel, Marjolein, Bao, Winnie, Ryan, Feargal J., Brook, Byron, Amenyogbe, Nelly, Marshall, Helen S., Lynn, Miriam A., Kollmann, Tobias R., Tumes, Damon J., Lynn, David J.

“…In addition to providing pathogen-specific immunity, vaccines can also confer nonspecific effects (NSEs) on mortality and morbidity unrelated to the targeted…”
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Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D by Kennedy, Susan A., Jarboui, Mohamed-Ali, Srihari, Sriganesh, Raso, Cinzia, Bryan, Kenneth, Dernayka, Layal, Charitou, Theodosia, Bernal-Llinares, Manuel, Herrera-Montavez, Carlos, Krstic, Aleksandar, Matallanas, David, Kotlyar, Max, Jurisica, Igor, Curak, Jasna, Wong, Victoria, Stagljar, Igor, LeBihan, Thierry, Imrie, Lisa, Pillai, Priyanka, Lynn, Miriam A., Fasterius, Erik, Al-Khalili Szigyarto, Cristina, Breen, James, Kiel, Christina, Serrano, Luis, Rauch, Nora, Rukhlenko, Oleksii, Kholodenko, Boris N., Iglesias-Martinez, Luis F., Ryan, Colm J., Pilkington, Ruth, Cammareri, Patrizia, Sansom, Owen, Shave, Steven, Auer, Manfred, Horn, Nicola, Klose, Franziska, Ueffing, Marius, Boldt, Karsten, Lynn, David J., Kolch, Walter

“…Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their…”
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A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines by Ryan, Feargal J., Norton, Todd S., McCafferty, Conor, Blake, Stephen J., Stevens, Natalie E., James, Jane, Eden, Georgina L., Tee, Yee C., Benson, Saoirse C., Masavuli, Makutiro G., Yeow, Arthur E.L., Abayasingam, Arunasingam, Agapiou, David, Stevens, Hannah, Zecha, Jana, Messina, Nicole L., Curtis, Nigel, Ignjatovic, Vera, Monagle, Paul, Tran, Huyen, McFadyen, James D., Bull, Rowena A., Grubor-Bauk, Branka, Lynn, Miriam A., Botten, Rochelle, Barry, Simone E., Lynn, David J.

“…Identifying the molecular mechanisms that promote optimal immune responses to coronavirus disease 2019 (COVID-19) vaccination is critical for future rational…”
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The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota by Blake, Stephen J., James, Jane, Ryan, Feargal J., Caparros-Martin, Jose, Eden, Georgina L., Tee, Yee C., Salamon, John R., Benson, Saoirse C., Tumes, Damon J., Sribnaia, Anastasia, Stevens, Natalie E., Finnie, John W., Kobayashi, Hiroki, White, Deborah L., Wesselingh, Steve L., O’Gara, Fergal, Lynn, Miriam A., Lynn, David J.

“…Immune agonist antibodies (IAAs) are promising immunotherapies that target co-stimulatory receptors to induce potent anti-tumor immune responses, particularly…”
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Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function by Sinclair, Jane E, Vedelago, Courtney, Ryan, Feargal J, Carney, Meagan, Redd, Meredith A, Lynn, Miriam A, Grubor-Bauk, Branka, Cao, Yuanzhao, Henders, Anjali K, Chew, Keng Yih, Gilroy, Deborah, Greaves, Kim, Labzin, Larisa, Ziser, Laura, Ronacher, Katharina, Wallace, Leanne M, Zhang, Yiwen, Macauslane, Kyle, Ellis, Daniel J, Rao, Sudha, Burr, Lucy, Bain, Amanda, Karawita, Anjana, Schulz, Benjamin L, Li, Junrong, Lynn, David J, Palpant, Nathan, Wuethrich, Alain, Trau, Matt, Short, Kirsty R

“…An estimated 65 million people globally suffer from post-acute sequelae of COVID-19 (PASC), with many experiencing cardiovascular symptoms (PASC-CVS) like…”
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Investigation of molecular alterations of AKT-3 in triple-negative breast cancer by O'Hurley, Gillian, Daly, Etáin, O'Grady, Anthony, Cummins, Robert, Quinn, Cecily, Flanagan, Louise, Pierce, Aisling, Fan, Yue, Lynn, Miriam A, Rafferty, Máirín, Fitzgerald, Dara, Pontén, Fredrik, Duffy, Michael J, Jirström, Karin, Kay, Elaine W, Gallagher, William M

“…Aims Triple‐negative breast cancer (TNBC) is responsible for a disproportionate number of breast cancer (BC) deaths, owing to its intrinsic aggressiveness and…”
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Leishmania : conserved evolution – diverse diseases by Lynn, Miriam A, McMaster, W. Robert

“…The landmark completion of the Leishmania major genome sequence and the recent publication of the L. infantum and L. braziliensis genomes revealed the…”
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The Leishmania mexicana A600 genes are functionally required for amastigote replication by Murray, Angus S., Lynn, Miriam A., McMaster, W. Robert

“…Leishmania parasites, the causative agent of leishmaniasis, have a digenetic lifecycle consisting of the morphologically distinct insect vector stage…”
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