Search Results - "Lynn, Edward G"

GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis by Ayaub, Ehab A, Kolb, Philipp S, Mohammed-Ali, Zahraa, Tat, Victor, Murphy, James, Bellaye, Pierre-Simon, Shimbori, Chiko, Boivin, Felix J, Lai, Rocky, Lynn, Edward G, Lhoták, Šárka, Bridgewater, Darren, Kolb, Martin RJ, Inman, Mark D, Dickhout, Jeffrey G, Austin, Richard C, Ask, Kjetil

“…Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) have been associated with fibrotic lung disease, although exactly how they modulate…”
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Heme Oxygenase-1 Deficiency Accelerates Formation of Arterial Thrombosis Through Oxidative Damage to the Endothelium, Which Is Rescued by Inhaled Carbon Monoxide by True, Andrea L, Olive, Michelle, Boehm, Manfred, San, Hong, Westrick, Randal J, Raghavachari, Nalini, Xu, Xiuli, Lynn, Edward G, Sack, Michael N, Munson, Peter J, Gladwin, Mark T, Nabel, Elizabeth G

“…Heme oxygenase (HO)-1 (encoded by Hmox1) catalyzes the oxidative degradation of heme to biliverdin and carbon monoxide. HO-1 is induced during inflammation and…”
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Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis by BASSERI, Sana, LHOTAK, Sarka, FULLERTON, Morgan D, PALANIVEL, Rengasamy, HUA JIANG, LYNN, Edward G, FORD, Rebecca J, MACLEAN, Kenneth N, STEINBERG, Gregory R, AUSTIN, Richard C

“…Regulation of energy metabolism is critical for the prevention of obesity, diabetes, and hepatic steatosis. Here, we report an important role for the…”
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Scratching the Surface-An Overview of the Roles of Cell Surface GRP78 in Cancer by Chen, Jack, Lynn, Edward G, Yousof, Tamana R, Sharma, Hitesh, MacDonald, Melissa E, Byun, Jae Hyun, Shayegan, Bobby, Austin, Richard C

“…The 78 kDa glucose-regulated protein (GRP78) is considered an endoplasmic reticulum (ER)-resident molecular chaperone that plays a crucial role in protein…”
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Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions by Dickhout, Jeffrey G, Lhoták, Šárka, Hilditch, Brooke A, Basseri, Sana, Colgan, Stephen M, Lynn, Edward G, Carlisle, Rachel E, Zhou, Ji, Sood, Sudesh K, Ingram, Alistair J, Austin, Richard C

“…Endoplasmic reticulum (ER) stress causes macrophage cell death within advanced atherosclerotic lesions, thereby contributing to necrotic core formation and…”
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Deficiency of TDAG51 Protects Against Atherosclerosis by Modulating Apoptosis, Cholesterol Efflux, and Peroxiredoxin‐1 Expression by Hossain, Gazi S., Lynn, Edward G., Maclean, Kenneth N., Zhou, Ji, Dickhout, Jeffrey G., Lhoták, Šárka, Trigatti, Bernardo, Capone, John, Rho, Jaerang, Tang, Damu, McCulloch, Christopher A., Al‐Bondokji, Imtisal, Malloy, Mary J., Pullinger, Clive R., Kane, John P., Li, Yonghong, Shiffman, Dov, Austin, Richard C.

“…Background Apoptosis caused by endoplasmic reticulum (ER) stress contributes to atherothrombosis, the underlying cause of cardiovascular disease (CVD). T‐cell…”
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Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions by Crane, Elizabeth D., Al-Hashimi, Ali A., Chen, Jack, Lynn, Edward G., Won, Kevin Doyoon, Lhoták, Šárka, Naeim, Magda, Platko, Khrystyna, Lebeau, Paul, Byun, Jae Hyun, Shayegan, Bobby, Krepinsky, Joan C., Rayner, Katey J., Marchiò, Serena, Pasqualini, Renata, Arap, Wadih, Austin, Richard C.

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GDF10 is a negative regulator of vascular calcification by Platko, Khrystyna, Gyulay, Gabriel, Lebeau, Paul F., MacDonald, Melissa E., Lynn, Edward G., Byun, Jae Hyun, Igdoura, Suleiman A., Holden, Rachel M., Roubtsova, Anna, Seidah, Nabil G., Krepinsky, Joan C., Austin, Richard C.

“…Cardiovascular mortality is particularly high and increasing in patients with chronic kidney disease, with vascular calcification (VC) as a major…”
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Small molecules targeting GRP78 mitigate anti-GRP78 autoantibody–mediated tissue factor procoagulant activity in cultured endothelial cells by Chen, Jack, Lynn, Edward G., Sharma, Hitesh, Byun, Jae H., Kenyon, Victor A., Sahu, Kamlesh K., Tyrrell, D. Lorne, Houghton, Michael, Gross, Peter L., Trigatti, Bernardo L., Shayegan, Bobby, Austin, Richard C.

“…The 78-kDa glucose-regulated protein (GRP78) expressed on the cell surface (csGRP78) has been reported to regulate tissue factor (TF) procoagulant activity…”
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4‐Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe−/− mice by Lynn, Edward G., Lhoták, Šárka, Lebeau, Paul, Byun, Jae Hyun, Chen, Jack, Platko, Khrystyna, Shi, Chunhua, O'Brien, R. Edward, Austin, Richard C.

“…ABSTRACT Endoplasmic reticulum stress plays an important role in cardiovascular disease (CVD) and atherosclerosis. We aimed to assess the ability of…”
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Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice by Yousof, Tamana R., Bouchard, Celeste C., Alb, Mihnea, Lynn, Edward G., Lhoták, Sárka, Jiang, Hua, MacDonald, Melissa, Li, Hui, Byun, Jae H., Makda, Yumna, Athanasopoulos, Maria, Maclean, Kenneth N., Cherrington, Nathan J., Naqvi, Asghar, Igdoura, Suleiman A., Krepinsky, Joan C., Steinberg, Gregory R., Austin, Richard C.

“…Endoplasmic reticulum stress is associated with insulin resistance and the development of nonalcoholic fatty liver disease. Deficiency of the endoplasmic…”
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SIRT2 is a negative regulator of anoxia–reoxygenation tolerance via regulation of 14-3-3 ζ and BAD in H9c2 cells by Lynn, Edward G., McLeod, Christopher J., Gordon, Jeffrey P., Bao, Jianjun, Sack, Michael N.

“…Knockdown or inhibition of SIRT2 enhances biological stress-tolerance. We extend this phenotype showing that SIRT2 knockdown reduces anoxia–reoxygenation…”
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Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity by Byun, Jae Hyun, Lebeau, Paul F, Platko, Khrystyna, Carlisle, Rachel E, Faiyaz, Mahi, Chen, Jack, MacDonald, Melissa E, Makda, Yumna, Yousof, Tamana, Lynn, Edward G, Dickhout, Jeffrey G, Krepinsky, Joan C, Weaver, Fiona, Igdoura, Suleiman A, Seidah, Nabil G, Austin, Richard C

“…PCSK9 modulates the uptake of circulating lipids through a range of receptors, including the low-density lipoprotein receptor (LDLR) and CD36. In the kidney,…”
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Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions by Crane, Elizabeth D, Al-Hashimi, Ali A, Chen, Jack, Lynn, Edward G, Won, Kevin Doyoon, Lhoták, Šárka, Naeim, Magda, Platko, Khrystyna, Lebeau, Paul, Byun, Jae Hyun, Shayegan, Bobby, Krepinsky, Joan C, Rayner, Katey J, Marchiò, Serena, Pasqualini, Renata, Arap, Wadih, Austin, Richard C

“…The 78-kDa glucose-regulated protein (GRP78) is an ER molecular chaperone that aids in protein folding and secretion. However, pathological conditions that…”
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Transient upregulation of PGC-1α diminishes cardiac ischemia tolerance via upregulation of ANT1 by Lynn, Edward G, Stevens, Mark V, Wong, Renee P, Carabenciov, Darin, Jacobson, Jeremy, Murphy, Elizabeth, Sack, Michael N

“…Abstract Prolonged cardiac overexpression of the mitochondrial biogenesis regulatory transcriptional coactivator PGC-1α disrupts cardiac contractile function…”
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TNFα protects cardiac mitochondria independently of its cell surface receptors by Lacerda, Lydia, McCarthy, Joy, Mungly, Shazia F. K., Lynn, Edward G., Sack, Michael N., Opie, Lionel H., Lecour, Sandrine

“…Our novel proposal is that TNFα exerts a direct effect on mitochondrial respiratory function in the heart, independently of its cell surface receptors…”
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Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1, -3, and -4 But Not -2: Isoform Specific Determinants of Specificity in Insulin Signaling by Lee, Sihoon, Lynn, Edward G, Kim, Jeong-a, Quon, Michael J

“…Protein kinase C-ζ, a downstream effector of phosphatidylinositol 3-kinase (PI3K), phosphorylates insulin receptor substrate (IRS)-1 on serine residues…”
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The regulation, control, and consequences of mitochondrial oxygen utilization and disposition in the heart and skeletal muscle during hypoxia by Lynn, Edward G, Lu, Zhongping, Minerbi, Diane, Sack, Michael N

“…The major oxygen-dependent function of mitochondria partitions molecular oxygen between oxidative phosphorylation and reactive oxygen species generation. When…”
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Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPARα/PGC1α and thermogenic glycerolipid/fatty acid cycling by Rame, J. Eduardo, Barouch, Lili A., Sack, Michael N., Lynn, Edward G., Abu-Asab, Mones, Tsokos, Maria, Kern, Steven J., Barb, Jennifer J., Munson, Peter J., Halushka, Marc K., Miller, Karen L., Fox-Talbot, Karen, Zhang, Jianhua, Hare, Joshua M., Solomon, Michael A., Danner, Robert L.

“…Objective: Evidence supports an antilipotoxic role for leptin in preventing inappropriate peripheral tissue lipid deposition. Obese, leptin-deficient mice…”
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Molecular characterization of the first avian LDL receptor: role in sterol metabolism of ovarian follicular cells by Hummel, Susanna, Lynn, Edward G, Osanger, Andreas, Hirayama, Satoshi, Nimpf, Johannes, Schneider, Wolfgang J

“…Low levels of expression and sluggish sterol-mediated regulation have been likely reasons for the failure to molecularly characterize a bona fide LDL receptor…”
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