Search Results - "Lynes, Sara E"

Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity by Berglund, Eric D, Li, Candice Y, Bina, Holly A, Lynes, Sara E, Michael, M. Dodson, Shanafelt, Armen B, Kharitonenkov, Alexei, Wasserman, David H

“…Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator shown to improve glycemic control. However, the molecular and functional mechanisms…”
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Skeletal Muscle AMP-activated Protein Kinase Is Essential for the Metabolic Response to Exercise in Vivo by Lee-Young, Robert S., Griffee, Susan R., Lynes, Sara E., Bracy, Deanna P., Ayala, Julio E., McGuinness, Owen P., Wasserman, David H.

“…AMP-activated protein kinase (AMPK) has been postulated as a super-metabolic regulator, thought to exert numerous effects on skeletal muscle function,…”
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Hepatic energy state is regulated by glucagon receptor signaling in mice by Berglund, Eric D, Lee-Young, Robert S, Lustig, Daniel G, Lynes, Sara E, Donahue, E Patrick, Camacho, Raul C, Meredith, M Elizabeth, Magnuson, Mark A, Charron, Maureen J, Wasserman, David H

“…The hepatic energy state, defined by adenine nucleotide levels, couples metabolic pathways with energy requirements. This coupling is fundamental in the…”
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Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver by Berglund, Eric D, Lustig, Daniel G, Baheza, Richard A, Hasenour, Clinton M, Lee-Young, Robert S, Donahue, E Patrick, Lynes, Sara E, Swift, Larry L, Charron, Maureen J, Damon, Bruce M, Wasserman, David H

“…Exercise is an effective intervention to treat fatty liver. However, the mechanism(s) that underlie exercise-induced reductions in fatty liver are unclear…”
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Statement of Retraction. Hepatic Glucagon Action Is Essential for Exercise-Induced Reversal of Mouse Fatty Liver. Diabetes 2011;60:2720-2729. DOI: 10.2337/db11-0455 by Berglund, Eric D, Lustig, Daniel G, Baheza, Richard A, Hasenour, Clinton M, Lee-Young, Robert S, Donahue, E Patrick, Lynes, Sara E, Swift, Larry L, Charron, Maureen J, Damon, Bruce M, Wasserman, David H

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Hepatic Glucagon Action Is Essential for Exercise-Induced Reversal of Mouse Fatty Liver by BERGLUND, Eric D, LUSTIG, Daniel G, WASSERMAN, David H, BAHEZA, Richard A, HASENOUR, Clinton M, LEE-YOUNG, Robert S, DONAHUE, E. Patrick, LYNES, Sara E, SWIFT, Larry L, CHARRON, Maureen J, DAMON, Bruce M

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FVB/N mice are hypersensitive to moderate insulin‐induced hypoglycemia while 129X1 mice are completely insensitive by Berglund, Eric D., Li, Candice Y., Lynes, Sara E., Ayala, Julio E., Wasserman, David H

“…Abstract only The phenotype of mutant mice is known to differ based on background strain. Insulin‐induced hypoglycemia was used as a metabolic stress to…”
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Activation of glucagon receptor signaling stimulates regulators of hepatic fat oxidation in vivo by Berglund, Eric D., Kang, Li, Lee‐Young, Robert S., Lustig, Daniel G., Lynes, Sara E., Donahue, E. Patrick, Wasserman, David H.

“…Abstract only Evidence suggests that glucagon (GN) has persistent effects on the liver that we hypothesize are related to AMPK, PPARα, and FGF‐21. These…”
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Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo by Berglund, Eric D, Kang, Li, Lee-Young, Robert S, Hasenour, Clinton M, Lustig, Daniel G, Lynes, Sara E, Donahue, E Patrick, Swift, Larry L, Charron, Maureen J, Wasserman, David H

“…Hepatic glucagon action increases in response to accelerated metabolic demands and is associated with increased whole body substrate availability, including…”
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