Search Results - "Lynch, Samuel"

Recombinant Human Platelet-Derived Growth Factor: Biology and Clinical Applications by Hollinger, Jeffrey O, Hart, Charles E, Hirsch, Steven N, Lynch, Samuel, Friedlaender, Gary E

“…The abilities of bone to remodel, fractures to repair, and bone grafts to incorporate are all fundamental reflections of the bone remodeling cycle. This…”
Get full text

Platelet‐Derived Growth Factor Promotes Periodontal Regeneration in Localized Osseous Defects: 36‐Month Extension Results From a Randomized, Controlled, Double‐Masked Clinical Trial by Nevins, Myron, Kao, Richard T., McGuire, Michael K., McClain, Pamela K., Hinrichs, James E., McAllister, Bradley S., Reddy, Michael S., Nevins, Marc L., Genco, Robert J., Lynch, Samuel E., Giannobile, William V.

“…Background: Recombinant human platelet‐derived growth factor (rhPDGF) is safe and effective for the treatment of periodontal defects in short‐term studies up…”
Get full text

Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration by Kaigler, Darnell, Avila, Gustavo, Wisner-Lynch, Leslie, Nevins, Marc L, Nevins, Myron, Rasperini, Giulio, Lynch, Samuel E, Giannobile, William V

“…Achieving successful tissue regeneration following traditional therapeutic protocols, combining bone grafts and barrier membranes, may be challenging in…”
Get more information

The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration by Friedlaender, Gary E, Lin, Sheldon, Solchaga, Luis A, Snel, Leo B, Lynch, Samuel E

“…Recombinant human PDGF BB homodimer (rhPDGF-BB) is a potent recruiter of, and strong mitogenic factor for, cells crucial to musculoskeletal tissue repair,…”
Get more information

Recombinant Human Platelet-Derived Growth Factor-BB and Beta-Tricalcium Phosphate (rhPDGF-BB/β-TCP): An Alternative to Autogenous Bone Graft by DiGiovanni, Christopher W, Lin, Sheldon S, Baumhauer, Judith F, Daniels, Timothy, Younger, Alastair, Glazebrook, Mark, Anderson, John, Anderson, Robert, Evangelista, Peter, Lynch, Samuel E

“…BACKGROUND:Joint arthrodesis employing autogenous bone graft (autograft) remains a mainstay in the treatment of many foot and ankle problems. However, graft…”
Get full text

Nanofibrous scaffolds incorporating PDGF-BB microspheres induce chemokine expression and tissue neogenesis in vivo by Jin, Qiming, Wei, Guobao, Lin, Zhao, Sugai, James V, Lynch, Samuel E, Ma, Peter X, Giannobile, William V

“…Platelet-derived growth factor (PDGF) exerts multiple cellular effects that stimulate wound repair in multiple tissues. However, a major obstacle for its…”
Get full text

Platelet‐Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain: Results of a Large Multicenter Randomized Controlled Trial by Nevins, Myron, Giannobile, William V., McGuire, Michael K., Kao, Richard T., Mellonig, James T., Hinrichs, James E., McAllister, Bradley S., Murphy, Kevin S., McClain, Pamela K., Nevins, Marc L., Paquette, David W., Han, Thomas J., Reddy, Michael S., Lavin, Philip T., Genco, Robert J., Lynch, Samuel E.

“…Background: Growth factors are generally accepted to be essential mediators of tissue repair via well‐established mechanisms of action that include stimulatory…”
Get full text

Periodontal Regeneration in Humans Using Recombinant Human Platelet‐ Derived Growth Factor‐BB (rhPDGF‐BB) and Allogenic Bone by Nevins, Myron, Camelo, Marcelo, Nevins, Marc L., Schenk, Robert K., Lynch, Samuel E.

“…Background: Purified recombinant human platelet‐derived growth factor BB (rhPDGF‐BB) is a potent wound healing growth factor and stimulator of the…”
Get full text

Clinical results using recombinant human platelet-derived growth factor and mineralized freeze-dried bone allograft in periodontal defects by Nevins, Myron, Hanratty, James, Lynch, Samuel E

“…Human studies have demonstrated the safety and effectiveness of highly purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in combination…”
Get more information

Augment bone graft products compare favorably with autologous bone graft in an ovine model of lumbar interbody spine fusion by Solchaga, Luis A, Hee, Christopher K, Aguiar, Dean J, Ratliff, Jack, Turner, A Simon, Seim, 3rd, Howard B, Hollinger, Jeffrey O, Snel, Leo B, Lynch, Samuel E

“…This study was designed to determine whether Augment Bone Graft (Augment, Biomimetic Therapeutics, Inc., Franklin, TN) and Augment Injectable Bone Graft…”
Get full text

rhPDGF-BB promotes healing of periodontal defects: 24-month clinical and radiographic observations by McGuire, Michael K, Kao, Richard T, Nevins, Myron, Lynch, Samuel E

“…A new therapeutic system using purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in combination with a biocompatible, osteoconductive,…”
Get more information

Percutaneous injection of Augment Injectable Bone Graft (rhPDGF-BB and β-tricalcium phosphate [β-TCP]/bovine Type I collagen matrix) increases vertebral bone mineral density in geriatric female baboons by Perrien, Daniel S., PhD, Young, Conan S., PhD, Alvarez-Urena, Pedro P., MS, Dean, David D., PhD, Lynch, Samuel E., DMD, DSc, Hollinger, Jeffrey O., DDS, PhD

“…Abstract Background context Recombinant human platelet-derived growth factor-BB (rhPDGF-BB) homodimer is a chemotactic, mitogenic, and angiogenic factor…”
Get full text

Periodontal regeneration in human Class II furcations using purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) with bone allograft by Camelo, Marcelo, Nevins, Marc L, Schenk, Robert K, Lynch, Samuel E, Nevins, Myron

“…This human clinical trial evaluated the clinical and histologic response to recombinant human platelet-derived growth factor-BB (rhPDGF-BB) delivered in bone…”
Get more information

Effect of rhPDGF-BB on bone turnover during periodontal repair by Sarment, David P., Cooke, Jason W., Miller, Sarah E., Jin, Qiming, McGuire, Michael K., Kao, Richard T., McClain, Pamela K., McAllister, Bradley S., Lynch, Samuel E., Giannobile, William V.

“…Purpose: Growth factors such as platelet‐derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia…”
Get full text

Agent-based simulation modeling of a Bus Rapid Transit (BRT) station using smart card data by SangHyung Ahn, Hislop-Lynch, Samuel Richard, Jiwon Kim, Roy Zhu

“…A Bus Rapid Transit (BRT) station with multiple loading zones tends to have a longer passenger-bus interface and, thus, lead to longer passenger walking times…”
Get full text

Growth factors and craniofacial surgery by Alvarez, Pedro, Hee, Christopher K, Solchaga, Luis, Snel, Leo, Kestler, Hans K, Lynch, Samuel E, Hollinger, Jeffrey O

“…The specialty of craniofacial surgery is broad and includes trauma, aesthetics, reconstruction of congenital deformities, and regeneration of tissues…”
Get full text

Platelet‐Derived Growth Factor Enhancement of Two Alloplastic Bone Matrices by Bateman, Jeremy, Intini, Giuseppe, Margarone, Joseph, Goodloe, Samuel, Bush, Peter, Lynch, Samuel E., Dziak, Rosemary

“…Background: The use of alloplastic matrices that mimic the mineral phase of bone has become a viable alternative to current mainstream therapies in dentistry…”
Get full text

Simultaneous augmentation of hard and soft tissues for implant site preparation using recombinant human platelet-derived growth factor: a human case report by Fagan, Mark C, Miller, Randolph E, Lynch, Samuel E, Kao, Richard T

“…This paper documents the treatment of a patient for whom a tissue engineering approach was used for both soft and hard tissue implant site development…”
Get more information

Evaluation of periodontal regeneration following grafting intrabony defects with bio-oss collagen: a human histologic report by Nevins, Marc L, Camelo, Marcelo, Lynch, Samuel E, Schenk, Robert K, Nevins, Myron

“…This study evaluated the clinical, radiographic, and histologic response to Bio-Oss Collagen when used alone or in combination with Bio-Gide bilayer collagen…”
Get more information

Effect of Bio-Oss® with or without platelet-derived growth factor on bone formation by "guided tissue regeneration": a pilot study in rats by Lioubavina-Hack, Natalia, Carmagnola, Daniela, Lynch, Samuel E., Karring, Thorkild

“…Aim: To investigate the effect of Bio‐Oss® with and without the local application of recombinant human platelet‐derived growth factor (rhPDGF‐BB) on bone…”
Get full text