Search Results - "Lynch, Robert J."

Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs by Hutchinson, John H, Cook, Jacquelynn J, Brashear, Karen M, Breslin, Michael J, Glass, Joan D, Gould, Robert J, Halczenko, Wasyl, Holahan, Marie A, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Hartman, George D

“…The structure−activity relationship of a series of orally active glycoprotein IIb/IIIa antagonists containing a nitrogen heterocycle grafted onto a…”
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High-throughput analysis of drug binding interactions for the human cardiac channel, Kv1.5 by Karczewski, Jerzy, Kiss, Laszlo, Kane, Stefanie A., Koblan, Kenneth S., Lynch, Robert J., Spencer, Robert H.

“…The voltage-gated potassium channel Kv1.5 is one of the key regulators of membrane potential repolarization in human atrial myocytes and is considered a…”
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Nonpeptide glycoprotein IIb/IIIa inhibitors: Substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists by Liverton, Nigel J., Armstrong, Donna J., Claremon, David A., Remy, David C., Baldvin, John J., Lynch, Robert J., Zhang, Guixiang, Gould, Robert J.

“…The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds…”
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Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp by Egbertson, Melissa S, Chang, Charles T.-C, Duggan, Mark E, Gould, Robert J, Halczenko, Wasyl, Hartman, George D, Laswell, William L, Lynch, Joseph J, Lynch, Robert J

“…Inhibitors of platelet-fibrinogen binding offer an opportunity to interrupt the final, common pathway for platelet aggregation. Small molecule inhibitors of…”
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Renin inhibitors containing C-termini derived from mercaptoheterocycles by Ashton, Wallace T, Cantone, Christine L, Meurer, Laura C, Tolman, Richard L, Greenlee, William J, Patchett, Arthur A, Lynch, Robert J, Schorn, Terry W, Strouse, John F, Siegl, Peter K. S

“…A series of transition-state analogues having heterocyclythio C-termini has been synthesized and evaluated for inhibition of human renin. Addition of…”
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Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation by Egbertson, Melissa S, Cook, Jacquelynn J, Bednar, Bohumil, Prugh, John D, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Hartman, George D, Homnick, Carl F, Holahan, Marie A, Libby, Laura A, Lynch, Joseph J, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Vassallo, Laura M

“…The synthesis and pharmacology of 4, a potent thienothiophene non-peptide fibrinogen receptor antagonist, are reported. Compound 4 inhibited the aggregation of…”
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Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists by Askew, Benny C, Bednar, Rodney A, Bednar, Bohumil, Claremon, David A, Cook, Jacquelynn J, McIntyre, Charles J, Hunt, Cecila A, Gould, Robert J, Lynch, Robert J, Lynch, Joseph J, Gaul, Stanley L, Stranieri, Maria T, Sitko, Gary R, Holahan, Marie A, Glass, Joan D, Hamill, Terrence, Gorham, Lynn M, Prueksaritanont, Thomayant, Baldwin, John J, Hartman, George D

“…The synthesis and pharmacological evaluation of 5 (L-738,167), a potent, selective non-peptide fibrinogen receptor antagonist is reported. Compound 5 inhibited…”
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Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors by Hartman, George D, Egbertson, Melissa S, Halczenko, Wasyl, Laswell, William L, Duggan, Mark E, Smith, Robert L, Naylor, Adel M, Manno, Patricia D, Lynch, Robert J

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Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation by Egbertson, Melissa S, Cook, Jacquelynn J, Bednar, Bohumil, Prugh, John D, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Hartman, George D, Homnick, Carl F, Holahan, Marie A, Libby, Laura A, Lynch, Joseph J, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T

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Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors by Weber, Ann E, Halgren, Thomas A, Doyle, John J, Lynch, Robert J, Siegl, Peter K. S, Parsons, William H, Greenlee, William J, Patchett, Arthur A

“…Using a computer model of the active site of human renin developed at Merck, we designed a series of novel P2-P1'-linked, macrocyclic renin inhibitors 3-10…”
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Nonpeptide glycoprotein IIB/IIIA inhibitors. 12. Potent and orally active centrally constrained thieno[2,3-c]pyridones by Halczenko, Wasyl, Cook, Jacquelynn J., Holahan, Marie A., Sitko, Gary R., Stranieri, Maria T., Zhang, Guixiang, Lynch, Robert J., Lynch, Joseph J., Gould, Robert J., Hartman, George D.

“…A series of potent, orally active thieno[2,3-c]pyridone GPIIb/IIIa inhibitors featuring β-alanine C-2 sulfonamide substitution is described…”
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Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics by Williams, Peter D, Perlow, Debra S, Payne, Linda S, Holloway, M. Katherine, Siegl, Peter K. S, Schorn, Terry W, Lynch, Robert J, Doyle, John J, Strouse, John F

“…A series of renin inhibitors containing lactam-bridged P1-P1' dipeptide mimetics based on the ACHPA (4(S)-amino-5-cyclohexyl-3(S)-hydroxypentanoic acid) design…”
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Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids by Ashton, Wallace T, Cantone, Christine L, Tolman, Richard L, Greenlee, William J, Lynch, Robert J, Schorn, Terry W, Strouse, John F, Siegl, Peter K. S

“…New transition-state analogues bearing C-termini derived from alpha-mercaptoalkanoic acids, esters, and amides were prepared and evaluated as inhibitors of…”
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Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini by Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Boger, Joshua, Poe, Martin, LaMont, Bruce I, Lynch, Robert J, Ulm, Edgar H

“…A series of statine-containing tetrapeptides, systematically modified at the carboxy terminus with various hydrophobic aromatic groups, is described. These…”
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Macrophage Dependence of Polyriboinosinic Acid-Polyribocytidylic Acid-Induced Resistance to Herpes Simplex Virus Infection in Mice by Martinez, D, Lynch, R J, Meeker, J B, Field, A K

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Nonpeptide glycoprotein IIb/IIIa inhibitors: 18. Indole alpha-sulfonamide acids are potent inhibitors of platelet aggregation by Brashear, Karen M., Cook, Jacquelynn J., Bednar, Bohumil, Bednar, Rodney A., Gould, Robert J., Halczenko, Wasyl, Holahan, Marie A., Lynch, Robert J., Hartman, George D., Hutchinson, John.H.

“…The structure-activity relationship (SAR) of a series of orally active glycoprotein IIb/IIIa antagonists containing an alkyl or aryl sulfonamide grafted onto…”
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Nonpeptide GPIIB/IIIA inhibitors. 16. Thieno[2,3- b]thiophene α-sulfonamides are potent inhibitors of platelet aggregation by Prugh, John D., Gould, Robert J., Lynch, Robert J., Zhang, Guixiang, Cook, Jacquelynn J., Holahan, Marie A., Stranieri, Maria T., Sitko, Gary R., Lee Gaul, S., Bednar, Rodney A., Bednar, Bohumil, Hartman, George D.

“…Centrally constrained thieno[2,3- b]thiophene sulfonamides have provided a potent, selective, orally active series of platelet aggregation inhibitors. Compound…”
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Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors by Hartman, George D., Duggan, Mark E., Hoffman, William F., Meissner, Robert J., Perkins, James J., Zartman, Amy E., Naylor-Olsen, Adel M., Cook, Jacquelynn J., Glass, Joan D., Lynch, Robert J., Zhang, Guixiang, Gould, Robert J.

“…A new series of potent, linearly-minimized, orally active, selective GPIIb/IIIa inhibitors is identified. Thus 15 (L-750,034) achieves interaction via a…”
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Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist by Duggan, Mark E, Naylor-Olsen, Adel M, Perkins, James J, Anderson, Paul S, Chang, Charles T.-C, Cook, Jacquelynn J, Gould, Robert J, Ihle, Nathan C, Hartman, George D

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Utilization of Available Technology to Support Ocean Mining by Rothman, S., Lynch, R.

“…With the large capital investment and high operating costs associated with ocean mining, it is vitally important that maximum use be made of existing…”
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