Search Results - "Lynch, Megan T"

Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish by Lynch, Megan T, Maloney, Kristin A, Xu, Huichun, Perry, James A, Center, Regeneron Genetics, Shuldiner, Alan R, Mitchell, Braxton D

“…Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting…”
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Evaluating genomic signatures of aging in brain tissue as it relates to Alzheimer’s disease by Lynch, Megan T., Taub, Margaret A., Farfel, Jose M., Yang, Jingyun, Abadir, Peter, De Jager, Philip L., Grodstein, Francine, Bennett, David A., Mathias, Rasika A.

“…Telomere length (TL) attrition, epigenetic age acceleration, and mitochondrial DNA copy number (mtDNAcn) decline are established hallmarks of aging. Each has…”
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Impact of parental relatedness on reproductive outcomes among the Old Order Amish of Lancaster County by Lynch, Megan T., Maloney, Kristin A., Pollin, Toni I., Streeten, Elizabeth A., Puffenberger, Erik G., Strauss, Kevin A., Shuldiner, Alan R., Mitchell, Braxton D.

“…Genetically isolated populations that arise due to recent bottleneck events have reduced genetic variation reflecting the common set of founders. Increased…”
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The burden of pathogenic variants in clinically actionable genes in a founder population by Lynch, Megan T., Maloney, Kristin A., Pollin, Toni I., Streeten, Elizabeth A., Xu, Huichun, Shuldiner, Alan R., Van Hout, Cristopher V., Gonzaga‐Jauregui, Claudia, Mitchell, Braxton D.

“…Founder populations may be enriched with certain genetic variants of high clinical impact compared to nonfounder populations due to bottleneck events and…”
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A 30-year-old woman with chronic hives, intermittent fevers, and joint pain by Cook, Kevin A, Lynch, Megan T, Weis, Peter J, White, Andrew A

“…Chronic urticaria with concomitant systemic symptoms may be seen in several rheumatologic and autoinflammatory conditions. Although most of these conditions…”
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