Search Results - "Lynch, Jeanette"

The Circadian Protein Period 1 Contributes to Blood Pressure Control and Coordinately Regulates Renal Sodium Transport Genes by Stow, Lisa R, Richards, Jacob, Cheng, Kit-Yan, Lynch, I Jeanette, Jeffers, Lauren A, Greenlee, Megan M, Cain, Brian D, Wingo, Charles S, Gumz, Michelle L

“…The circadian clock protein period 1 (Per1) contributes to the regulation of expression of the α subunit of the renal epithelial sodium channel at the basal…”
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Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure by Alli, Abdel, Yu, Ling, Holzworth, Meaghan, Richards, Jacob, Cheng, Kit-Yan, Lynch, I Jeanette, Wingo, Charles S, Gumz, Michelle L

“…Circadian rhythms govern physiological functions and are important for overall health. The molecular circadian clock comprises several transcription factors…”
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A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention by Richards, Jacob, Cheng, Kit-Yan, All, Sean, Skopis, George, Jeffers, Lauren, Lynch, I Jeanette, Wingo, Charles S, Gumz, Michelle L

“…The circadian clock plays an important role in the regulation of physiological processes, including renal function and blood pressure. We have previously shown…”
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Differences in renal BMAL1 contribution to Na + homeostasis and blood pressure control in male and female mice by Crislip, G Ryan, Douma, Lauren G, Masten, Sarah H, Cheng, Kit-Yan, Lynch, I Jeanette, Johnston, Jermaine G, Barral, Dominique, Glasford, Krystal B, Holzworth, Meaghan R, Verlander, Jill W, Wingo, Charles S, Gumz, Michelle L

“…The renal circadian clock has a major influence on the function of the kidney. Aryl hydrocarbon receptor nuclear translocator-like protein 1 [ARNTL; also known…”
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Benzamil-mediated urine alkalization is caused by the inhibition of H + -K + -ATPases by Ayasse, Niklas, Berg, Peder, Andersen, Jesper Frank, Svendsen, Samuel Levi, Sørensen, Mads V, Fedosova, Natalya U, Lynch, I Jeanette, Wingo, Charles S, Leipziger, Jens

“…Epithelial Na channel (ENaC) blockers elicit acute and substantial increases of urinary pH. The underlying mechanism remains to be understood. Here, we…”
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Kidney-specific KO of the circadian clock protein PER1 alters renal Na + handling, aldosterone levels, and kidney/adrenal gene expression by Douma, Lauren G, Costello, Hannah M, Crislip, G Ryan, Cheng, Kit-Yan, Lynch, I Jeanette, Juffre, Alexandria, Barral, Dominique, Masten, Sarah, Roig, Emilio, Beguiristain, Kevin, Li, Wendy, Bratanatawira, Phillip, Wingo, Charles S, Gumz, Michelle L

“…PERIOD 1 (PER1) is a circadian clock transcription factor that is regulated by aldosterone, a hormone that increases blood volume and Na retention to increase…”
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The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice by Gumz, Michelle L, Stow, Lisa R, Lynch, I Jeanette, Greenlee, Megan M, Rudin, Alicia, Cain, Brian D, Weaver, David R, Wingo, Charles S

“…The mineralocorticoid aldosterone is a major regulator of sodium transport in target epithelia and contributes to the control of blood pressure and cardiac…”
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Male kidney-specific BMAL1 knockout mice are protected from K + -deficient, high-salt diet-induced blood pressure increases by Crislip, G Ryan, Costello, Hannah M, Juffre, Alexandria, Cheng, Kit-Yan, Lynch, I Jeanette, Johnston, Jermaine G, Drucker, Charles B, Bratanatawira, Phillip, Agarwal, Annanya, Mendez, Victor M, Thelwell, Ryanne S, Douma, Lauren G, Wingo, Charles S, Alli, Abdel A, Scindia, Yogesh M, Gumz, Michelle L

“…The circadian clock protein basic helix-loop-helix aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1) is a transcription factor that impacts…”
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The renal H+-K+-ATPases: physiology, regulation, and structure by Gumz, Michelle L, Lynch, I Jeanette, Greenlee, Megan M, Cain, Brian D, Wingo, Charles S

“…The H(+)-K(+)-ATPases are ion pumps that use the energy of ATP hydrolysis to transport protons (H(+)) in exchange for potassium ions (K(+)). These enzymes…”
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Aldosterone alters the chromatin structure of the murine endothelin-1 gene by Welch, Amanda K., Jeanette Lynch, I., Gumz, Michelle L., Cain, Brian D., Wingo, Charles S.

“…Aldosterone increases sodium reabsorption in the renal collecting duct and systemic blood pressure. Paradoxically, aldosterone also induces transcription of…”
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Mineralocorticoids Stimulate the Activity and Expression of Renal H+,K+-ATPases by GREENLEE, Megan M, JEANETTE LYNCH, I, GUMZ, Michelle L, CAIN, Brian D, WINGO, Charles S

“…In the renal collecting duct, mineralocorticoids drive Na(+) reabsorption, K(+) secretion, and H(+) secretion through coordinated actions on apical and…”
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Aldosterone Modulates Steroid Receptor Binding to the Endothelin-1 Gene (edn1) by Stow, Lisa R., Gumz, Michelle L., Lynch, I.Jeanette, Greenlee, Megan M., Rudin, Alicia, Cain, Brian D., Wingo, Charles S.

“…Aldosterone and endothelin-1 (ET-1) act on collecting duct cells of the kidney and are important regulators of renal sodium transport and cardiovascular…”
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Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension by Douma, Lauren G, Solocinski, Kristen, Holzworth, Meaghan R, Crislip, G Ryan, Masten, Sarah H, Miller, Amber H, Cheng, Kit-Yan, Lynch, I Jeanette, Cain, Brian D, Wingo, Charles S, Gumz, Michelle L

“…The circadian clock is integral to the maintenance of daily rhythms of many physiological outputs, including blood pressure. Our laboratory has previously…”
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Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice by Douma, Lauren G, Holzworth, Meaghan R, Solocinski, Kristen, Masten, Sarah H, Miller, Amber H, Cheng, Kit-Yan, Lynch, I Jeanette, Cain, Brian D, Wingo, Charles S, Gumz, Michelle L

“…Many physiological functions have a circadian rhythm, including blood pressure (BP). BP is highest during the active phase, whereas during the rest period, BP…”
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Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) receptors in the mouse cortical collecting duct by Lynch, I Jeanette, Welch, Amanda K, Kohan, Donald E, Cain, Brian D, Wingo, Charles S

“…The collecting duct (CD) is a major renal site for the hormonal regulation of Na homeostasis and is critical for systemic arterial blood pressure control. Our…”
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Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1 by Lynch, I Jeanette, Welch, Amanda K, Gumz, Michelle L, Kohan, Donald E, Cain, Brian D, Wingo, Charles S

“…Aldosterone increases blood pressure (BP) by stimulating sodium (Na) reabsorption within the distal nephron and collecting duct (CD). Aldosterone also…”
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Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior by Costello, Hannah M, Crislip, G Ryan, Cheng, Kit-Yan, Lynch, I Jeanette, Juffre, Alexandria, Bratanatawira, Phillip, Mckee, Annalisse, Thelwell, Ryanne S, Mendez, Victor M, Wingo, Charles S, Douma, Lauren G, Gumz, Michelle L

“…Abstract Brain and muscle ARNT-like 1 (BMAL1) is a core circadian clock protein and transcription factor that regulates many physiological functions, including…”
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ENaC activity in the cortical collecting duct of HKα 1 H + ,K + -ATPase knockout mice is uncoupled from Na + intake by Mironova, Elena, Lynch, I Jeanette, Berman, Jonathan M, Gumz, Michelle L, Stockand, James D, Wingo, Charles S

“…Modulation of the epithelial Na channel (ENaC) activity in the collecting duct (CD) is an important mechanism for normal Na homeostasis. ENaC activity is…”
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Apical P2XR contribute to [Ca2+]i signaling and Isc in mouse renal MCD by Li, Liuzhe, Jeanette Lynch, I., Zheng, Wencui, Cash, Melanie N., Teng, Xueling, Wingo, Charles S., Verlander, Jill W., Xia, Shen-Ling

“…We examined P2X receptor expression and distribution in the mouse collecting duct (CD) and their functional role in Ca2+ signaling. Both P2X1 and P2X4 were…”
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Kidney Specific BMAL1 Knockout Reveal Differences in Circadian Rhythms of Blood Pressure Following a Low Potassium/High Salt Diet: SA-PO777 by Drucker, Charles B., Crislip, G. R., Costello, Hannah M., Jeanette Lynch, I., Wingo, Charles S., Gumz, Michelle L.

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