Search Results - "Lynch, Diana M."

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys by Barouch, Dan H., Liu, Jinyan, Li, Hualin, Maxfield, Lori F., Abbink, Peter, Lynch, Diana M., Iampietro, M. Justin, SanMiguel, Adam, Seaman, Michael S., Ferrari, Guido, Forthal, Donald N., Ourmanov, Ilnour, Hirsch, Vanessa M., Carville, Angela, Mansfield, Keith G., Stablein, Donald, Pau, Maria G., Schuitemaker, Hanneke, Sadoff, Jerald C., Billings, Erik A., Rao, Mangala, Robb, Merlin L., Kim, Jerome H., Marovich, Mary A., Goudsmit, Jaap, Michael, Nelson L.

“…Protective efficacy of novel vaccine candidates in rhesus monkeys opens new paths for the development of an HIV-1 vaccine. Vaccines protect against virulent…”
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Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys by Barouch, Dan H, O'Brien, Kara L, Simmons, Nathaniel L, King, Sharon L, Abbink, Peter, Maxfield, Lori F, Sun, Ying-Hua, La Porte, Annalena, Riggs, Ambryice M, Lynch, Diana M, Clark, Sarah L, Backus, Katherine, Perry, James R, Seaman, Michael S, Carville, Angela, Mansfield, Keith G, Szinger, James J, Fischer, Will, Muldoon, Mark, Korber, Bette

“…The worldwide diversity of HIV-1 presents an unprecedented challenge for vaccine development. Antigens derived from natural HIV-1 sequences have elicited only…”
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Adenovirus Serotype 5 Neutralizing Antibodies Target both Hexon and Fiber following Vaccination and Natural Infection by Bradley, Ritu R, Lynch, Diana M, Iampietro, Mark J, Borducchi, Erica N, Barouch, Dan H

“…The immunogenicity of adenovirus serotype 5 (Ad5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against the…”
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Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D by ABBINK, Peter, LEMCKERT, Angelique A. C, O'BRIEN, Kara L, CARVILLE, Angela, MANSFIELD, Keith G, GOUDSMIT, Jaap, HAVENGA, Menzo J. E, BAROUCH, Dan H, EWALD, Bonnie A, LYNCH, Diana M, DENHOLTZ, Matthew, SMITS, Shirley, HOLTERMAN, Lennart, DAMEN, Irma, VOGELS, Ronald, THORNER, Anna R

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Adenovirus Serotype 5-Specific Neutralizing Antibodies Target Multiple Hexon Hypervariable Regions by BRADLEY, Ritu R, MAXFELD, Lori F, LYNCH, Diana M, LAMPIETRO, Mark J, BORDUCCHI, Erica N, BAROUCH, Dan H

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Breadth of Neutralizing Antibodies Elicited by Stable, Homogeneous Clade A and Clade C HIV-1 gp140 Envelope Trimers in Guinea Pigs by NKOLOLA, Joseph P, HANQIN PENG, MONTEFIORI, David C, SEAMAN, Michael S, BING CHEN, BAROUCH, Dan H, SETTEMBRE, Ethan C, FREEMAN, Michael, GRANDPRE, Lauren E, DEVOY, Colleen, LYNCH, Diana M, LA PORTE, Annalena, SIMMONS, Nathaniel L, BRADLEY, Ritu

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Multiple Innate Immune Pathways Contribute to the Immunogenicity of Recombinant Adenovirus Vaccine Vectors by RHEE, Elizabeth G, BLATTMAN, Joseph N, GREENBERG, Philip D, BAROUCH, Dan H, KASTURI, Sudhir P, KELLEY, R. Phelps, KAUFMAN, David R, LYNCH, Diana M, LA PORTE, Annalena, SIMMONS, Nathaniel L, CLARK, Sarah L, PULENDRAN, Bali

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Magnitude and Phenotype of Cellular Immune Responses Elicited by Recombinant Adenovirus Vectors and Heterologous Prime-Boost Regimens in Rhesus Monkeys by JINYAN LIU, EWALD, Bonnie A, BAROUCH, Dan H, LYNCH, Diana M, DENHOLTZ, Matthew, ABBINK, Peter, LEMCKERT, Angelique A. C, CARVILLE, Angela, MANSFIELD, Keith G, HAVENGA, Menzo J, GOUDSMIT, Jaap

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Immunogenicity of Heterologous Prime-Boost Regimens Involving Recombinant Adenovirus Serotype 11 (Ad11) and Ad35 Vaccine Vectors in the Presence of Anti-Ad5 Immunity by LEMCKERT, Angelique A. C, SUMIDA, Shawn M, GOUDSMIT, Jaap, HAVENGA, Menzo J. E, BAROUCH, Dan H, HOLTERMAN, Lennart, VOGELS, Ronald, TRUITT, Diana M, LYNCH, Diana M, NANDA, Anjali, EWALD, Bonnie A, GORGONE, Darci A, LIFTON, Michelle A

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TLR4 Ligands Augment Antigen-Specific CD8+ T Lymphocyte Responses Elicited by a Viral Vaccine Vector by RHEE, Elizabeth G, PHELPS KELLEY, R, AGARWAL, Isha, LYNCH, Diana M, LA PORTER, Annalena, SIMMONS, Nathaniel L, CLARK, Sarah L, BAROUCH, Dan H

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Modulation of DNA Vaccine-Elicited CD8+ T-Lymphocyte Epitope Immunodominance Hierarchies by Liu, Jinyan, Ewald, Bonnie A, Lynch, Diana M, Nanda, Anjali, Sumida, Shawn M, Barouch, Dan H

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Protective Efficacy of a Single Immunization of a Chimeric Adenovirus Vector-Based Vaccine against Simian Immunodeficiency Virus Challenge in Rhesus Monkeys by BAROUCH, Dan H, JINYAN LIU, LANDUCCI, Gary, FORTHAL, Donald N, SELF, Steven G, CARVILLE, Angela, MANSFIELD, Keith, GOUDSMIT, Jaap, LYNCH, Diana M, O'BRIEN, Kara L, LA PORTER, Annalena, SIMMONS, Nathaniel L, RIGGS, Ambryice M, CLARK, Sarah, ABBINK, Peter, MONTEFIORI, David C

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Immunogenicity of Recombinant Fiber-Chimeric Adenovirus Serotype 35 Vector-Based Vaccines in Mice and Rhesus Monkeys by NANDA, Anjali, LYNCH, Diana M, LIFTON, Michelle A, LING SHEN, CARVILLE, Angela, MANSFIELD, Keith G, HAVENGA, Menzo J. E, BAROUCH, Dan H, GOUDSMIT, Jaap, LEMCKERT, Angelique A. C, EWALD, Bonnie A, SUMIDA, Shawn M, TRUITT, Diana M, ABBINK, Peter, KISHKO, Michael G, GORGONE, Darci A

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Immunogenicity of Heterologous Recombinant Adenovirus Prime-Boost Vaccine Regimens Is Enhanced by Circumventing Vector Cross-Reactivity by THORNER, Anna R, LEMCKERT, Angelique A. C, GOUDSMIT, Jaap, LYNCH, Diana M, EWALD, Bonnie A, DENHOLTZ, Matthew, HAVENGA, Menzo J. E, BAROUCH, Dan H

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Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys by Barouch, Dan H, Liu, Jinyan, O'Brien, Kara L, Lynch, Diana M, Simmons, Nathaniel L, La Porte, Annalena, Riggs, Ambryice M, Abbink, Peter, Coffey, Rory T, Grandpre, Lauren E, Seaman, Michael S, Landucci, Gary, Forthal, Donald N, Montefiori, David C, Carville, Angela, Mansfield, Keith G, Havenga, Menzo J, Pau, Maria G, Goudsmit, Jaap

“…A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these…”
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Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity by Barouch, Dan H, Roberts, Diane M, Nanda, Anjali, Havenga, Menzo J. E, Abbink, Peter, Lynch, Diana M, Ewald, Bonnie A, Liu, Jinyan, Thorner, Anna R, Swanson, Patricia E, Gorgone, Darci A, Lifton, Michelle A, Lemckert, Angelique A. C, Holterman, Lennart, Chen, Bing, Dilraj, Athmanundh, Carville, Angela, Mansfield, Keith G, Goudsmit, Jaap

“…A common viral immune evasion strategy involves mutating viral surface proteins in order to evade host neutralizing antibodies. Such immune evasion tactics…”
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Modulation of DNA Vaccine-Elicited CD8 super(+) T-Lymphocyte Epitope Immunodominance Hierarchies by Liu, Jinyan, Ewald, Bonnie A, Lynch, Diana M, Nanda, Anjali, Sumida, Shawn M, Barouch, Dan H

“…Generating broad cellular immune responses against a diversity of viral epitopes is a major goal of current vaccine strategies for human immunodeficiency virus…”
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Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity by Roberts, Diane M, Nanda, Anjali, Havenga, Menzo J E, Abbink, Peter, Lynch, Diana M, Ewald, Bonnie A, Liu, Jinyan, Thorner, Anna R, Swanson, Patricia E, Gorgone, Darci A, Lifton, Michelle A, Lemckert, Angelique A C, Holterman, Lennart, Chen, Bing, Dilraj, Athmanundh, Carville, Angela, Mansfield, Keith G, Goudsmit, Jaap, Barouch, Dan H

“…A common viral immune evasion strategy involves mutating viral surface proteins in order to evade host neutralizing antibodies. Such immune evasion tactics…”
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