Search Results - "Lynch, DR"

Interactions between Ifenprodil and the NR2B Subunit of the N-Methyl-D-aspartate Receptor (∗) by Gallagher, Michael J., Huang, Hui, Pritchett, Dolan B., Lynch, David R.

“…Ifenprodil is an atypical noncompetitive modulator of the N-methyl-D-aspartate (NMDA) receptor (NR) which demonstrates a 140-fold preference for NR2B over NR2A…”
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Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal by Iizuka, T, Sakai, F, Ide, T, Monzen, T, Yoshii, S, Iigaya, M, Suzuki, K, Lynch, D R, Suzuki, N, Hata, T, Dalmau, J

“…To report the definitive diagnosis of anti-NMDA receptor (NMDAR) encephalitis in four Japanese women previously diagnosed with "juvenile acute nonherpetic…”
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Pharmacological therapeutics in Friedreich ataxia: the present state by Strawser, Cassandra, Schadt, Kimberly, Hauser, Lauren, McCormick, Ashley, Wells, McKenzie, Larkindale, Jane, Lin, Hong, Lynch, David R

“…Friedreich ataxia (FRDA) is a progressive, inherited, neurodegenerative disease for which there is currently no cure or approved treatment. FRDA is caused by…”
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Reducing bias in trials due to reactions to measurement: experts produced recommendations informed by evidence by French, David P, Miles, Lisa M, Elbourne, Diana, Farmer, Andrew, Gulliford, Martin, Locock, Louise, Sutton, Stephen, McCambridge, Jim, Bower, Prof Peter, Clemes, Dr Stacy, Conner, Prof Mark, Dundas, Ms Ruth, Elbourne, Prof Diana, Eldridge, Prof Sandra, Farmer, Prof Andrew, French, Prof David, Gamble, Prof Carrol, Gulliford, Prof Martin, Kee, Prof Frank, Leyland, Prof Alastair, Locock, Prof Louise, Lynch, Dr Rebecca, MacLennan, Prof Graeme, McCambridge, Prof Jim, Miles, Dr Lisa, Rowley, Dr Samuel CS, Sharples, Prof Linda, Sniehotta, Prof Falko F, Snowdon, Dr Claire, Sprangers, Prof Mirjam, Sutton, Prof Stephen

“…This study (MEasurement Reactions In Trials) aimed to produce recommendations on how best to minimize bias from measurement reactivity (MR) in randomized…”
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N-methyl-D-aspartate Receptor Subtypes: Multiple Roles in Excitotoxicity and Neurological Disease by Waxman, Elisa A., Lynch, David R.

“…N-methyl-D-aspartate (NMDA) receptors are the major mediator of excitotoxicity. Although physiological activation of the NMDA receptor is necessary for cell…”
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Assessment of neurological efficacy of idebenone in pediatric patients with Friedreich's ataxia: data from a 6-month controlled study followed by a 12-month open-label extension study by Meier, Thomas, Perlman, Susan L., Rummey, Christian, Coppard, Nicholas J., Lynch, David R.

“…The aim of this study was to investigate the efficacy of idebenone on neurological function as assessed by ICARS and FARS neurological rating scales in…”
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Open-label pilot study of interferon gamma-1b in Friedreich ataxia by Seyer, L., Greeley, N., Foerster, D., Strawser, C., Gelbard, S., Dong, Y., Schadt, K., Cotticelli, M. G., Brocht, A., Farmer, J., Wilson, R. B., Lynch, D. R.

“…Objectives/Aims This is an open‐label trial of the safety of interferon gamma‐1b (IFN‐γ) and its effect on frataxin levels and neurologic measures in 12…”
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The E46K mutation in alpha-synuclein increases amyloid fibril formation by Greenbaum, Eric A, Graves, Charles L, Mishizen-Eberz, Amanda J, Lupoli, Michael A, Lynch, David R, Englander, S Walter, Axelsen, Paul H, Giasson, Benoit I

“…The identification of a novel mutation (E46K) in one of the KTKEGV-type repeats in the amino-terminal region of alpha-synuclein suggests that this region and,…”
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Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation by Hodara, Roberto, Norris, Erin H, Giasson, Benoit I, Mishizen-Eberz, Amanda J, Lynch, David R, Lee, Virginia M-Y, Ischiropoulos, Harry

“…Previous studies have shown the presence of nitrated alpha-synuclein (alpha-syn) in human Lewy bodies and other alpha-syn inclusions. Herein, the effects of…”
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Idebenone in Friedreich ataxia cardiomyopathy—results from a 6-month phase III study (IONIA) by Lagedrost, Sarah J., BA, Sutton, Martin St. John, MBBS, Cohen, Meryl S., MD, Satou, Gary M., MD, Kaufman, Beth D., MD, Perlman, Susan L., MD, Rummey, Christian, PhD, Meier, Thomas, PhD, Lynch, David R., MD, PhD

“…Background Friedreich ataxia (FRDA) is commonly associated with hypertrophic cardiomyopathy, but little is known about its frequency, severity, or treatment…”
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Excitotoxicity: perspectives based on N-methyl-D-aspartate receptor subtypes by Lynch, David R, Guttmann, Rodney P

“…Since excitotoxicity has been implicated in a variety of neuropathological conditions, understanding the pathways involved in this type of cell death is of…”
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Clinical evaluation of idiopathic paroxysmal kinesigenic dyskinesia: New diagnostic criteria by BRUNO, M. K, HALLETT, M, SOONG, B.-W, ASHIZAWA, T, JANKOVIC, J, RENNER, D, FU, Y.-H, PTACEK, L. J, GWINN-HARDY, K, SORENSEN, B, CONSIDINE, E, TUCKER, S, LYNCH, D. R, MATHEWS, K. D, SWOBODA, K. J, HARRIS, J

“…Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterized by short episodes of involuntary movement attacks triggered by sudden voluntary…”
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Therapeutic approaches for the treatment of Friedreich's ataxia by Strawser, Cassandra J, Schadt, Kimberly A, Lynch, David R

“…Friedreich ataxia (FRDA) is an inherited, progressive, neurodegenerative disease for which there is presently no cure or effective therapeutic intervention…”
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Skill assessment for coupled biological/physical models of marine systems by Lynch, Daniel R., McGillicuddy, Dennis J., Werner, Francisco E.

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Measuring Friedreich ataxia : Complementary features of examination and performance measures by LYNCH, D. R, FARMER, J. M, TSOU, A. Y, PERLMAN, S, SUBRAMONY, S. H, GOMEZ, C. M, ASHIZAWA, T, WILMOT, G. R, WILSON, R. B, BALCER, L. J

“…To examine the potential validity of performance measures and examination-based scales in Friedreich ataxia (FA) by examining their correlation with disease…”
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Definitions of peri-procedural myocardial infarction and the association with one-year mortality: Insights from CHAMPION trials by Olivier, Christoph B., Sundaram, Vandana, Bhatt, Deepak L., Leonardi, Sergio, Lopes, Renato D., Ding, Victoria Y., Yang, Lingyao, Stone, Gregg W., Steg, Ph. Gabriel, Gibson, C. Michael, Hamm, Christian W., Price, Matthew J., White, Harvey D., Desai, Manisha, Lynch, Donald R., Harrington, Robert A., Mahaffey, Kenneth W.

“…Controversies exist over the appropriate definition for peri-procedural myocardial infarction (PPMI) and its association with mortality. This study aims to…”
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Tomato Ve Disease Resistance Genes Encode Cell Surface-like Receptors by Kawchuk, Lawrence M., Hachey, John, Lynch, Dermot R., Kulcsar, Frank, van Rooijen, Gijs, Waterer, Doug R., Robertson, Albert, Kokko, Eric, Byers, Robert, Howard, Ronald J., Fischer, Rainer, Prüfer, Dirk

“…In tomato, Ve is implicated in race-specific resistance to infection by Verticillium species causing crop disease. Characterization of the Ve locus involved…”
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Mechanisms regulating large-scale seasonal fluctuations in Alexandrium fundyense populations in the Gulf of Maine: Results from a physical–biological model by McGillicuddy, D.J., Anderson, D.M., Lynch, D.R., Townsend, D.W.

“…Observations of Alexandrium fundyense in the Gulf of Maine indicate several salient characteristics of the vegetative cell distributions: patterns of abundance…”
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Seasonal mean circulation in the Yellow Sea — a model-generated climatology by E. Naimie, Christopher, Ann Blain, Cheryl, R. Lynch, Daniel

“…The three-dimensional climatological circulation is computed for the Yellow and Bohai Seas in a series of six bimonthly realizations. The model (QUODDY, Lynch…”
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N-Methyl-D-aspartate Receptor Subtype Mediated Bidirectional Control of p38 Mitogen-activated Protein Kinase by Waxman, Elisa A., Lynch, David R.

“…N-methyl-d-aspartate receptor (NMDAR) stimulation activates many downstream mechanisms involved in both cell survival and cell death. The manner in which the…”
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