Tidal volume delivery during nasal intermittent positive pressure ventilation: infant cannula vs. nasal continuous positive airway pressure prongs

Tidal volume delivery during nasal intermittent positive pressure ventilation: infant cannula vs. nasal continuous positive airway pressure prongs

Objective To measure tidal volume delivery during nasal intermittent positive pressure ventilation with two nasal interfaces: infant cannula and nasal prongs. Study design A single-center crossover study of neonates with mild respiratory distress. Fifteen preterm neonates were randomized to initial...

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Bibliographic Details
Published in:Journal of perinatology Vol. 44; no. 2; pp. 244 - 249
Main Authors: Lynch, Ashley L., Matlock, David N., Akmyradov, Chary, Weisner, Michael D., Beck, Jennifer, Sinderby, Christer, Courtney, Sherry E.
Format: Journal Article
Language:English
Published: New York Nature Publishing Group US 01-02-2024
Nature Publishing Group
Subjects:
631/443/1784
692/699/1785
692/700/1720
Babies
Cannula
Cannulae
Continuous Positive Airway Pressure
Critical care
Cross-Over Studies
Hospitals
Humans
Infant
Infant, Newborn
Infant, Premature
Infants
Interfaces
Intermittent Positive-Pressure Ventilation
Lungs
Mechanical ventilation
Medicine
Medicine & Public Health
Mortality
Neonates
Pediatric Surgery
Pediatrics
Pressure
Respiratory failure
Software
Statistical analysis
Tidal Volume
Variance analysis
Ventilation
Ventilators
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Summary:Objective To measure tidal volume delivery during nasal intermittent positive pressure ventilation with two nasal interfaces: infant cannula and nasal prongs. Study design A single-center crossover study of neonates with mild respiratory distress. Fifteen preterm neonates were randomized to initial interface of infant cannula or nasal prongs and monitored on a sequence of pressure settings first on the initial interface, then repeated on the alternate interface. We compared relative tidal volumes between the two interfaces with two-way repeated measures ANOVA during three breath types: synchronized (I), patient effort without ventilator breaths (II), and ventilator breaths without patient effort (III). Clinical trial #NCT04326270. Results Type III breaths delivered no significant tidal volume. No significant difference was measured in relative tidal volume delivery between the interfaces when breath types were matched. Conclusions Nasal intermittent positive pressure ventilation delivers neither clinically nor statistically significant tidal volume with either infant cannula or nasal prongs.
Bibliography:ObjectType-Article-2
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ISSN:0743-8346
1476-5543
1476-5543
DOI:10.1038/s41372-023-01846-7