Search Results - "Lyle, Karen"

GSK3β phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment by Kumar, Praveen, Lyle, Karen S, Gierke, Sarah, Matov, Alexandre, Danuser, Gaudenz, Wittmann, Torsten

“…Polarity of the microtubule (MT) cytoskeleton is essential for many cell functions. Cytoplasmic linker-associated proteins (CLASPs) are MT-associated proteins…”
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p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway by Radu, Maria, Lyle, Karen, Hoeflich, Klaus P., Villamar-Cruz, Olga, Koeppen, Hartmut, Chernoff, Jonathan

“…p21-activated kinases (Paks) have been shown to regulate cytoskeleton rearrangements, cell proliferation, attachment, and migration in a variety of cellular…”
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Delivery of gynecologic oncology care: Optimizing scope of advanced practice providers to enhance patient care: A Society of Gynecologic Oncology Position Paper by Rash, Joanne K., Lyle, Karen D., Jairam-Thodla, Arati, Ioffe, Yevgeniya

“…•Advanced practice providers (APPs) possess multiple skill sets utilized for gynecologic oncology care.•With the aging population and future physician…”
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Reactions of the Diiron Enzyme Stearoyl-Acyl Carrier Protein Desaturase by Fox, Brian G, Lyle, Karen S, Rogge, Corina E

“…Stearoyl-acyl carrier protein Δ9 desaturase (Δ9D) produces oleic acid, a nutritionally valuable fatty acid containing a cis double bond between C-9 and C-10…”
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cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics by Lyle, Karen S., Raaijmakers, Judith H., Bruinsma, Wytse, Bos, Johannes L., de Rooij, Johan

“…Epithelial cell migration is a complex process crucial for embryonic development, wound healing and tumor metastasis. It depends on alterations in cell–cell…”
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Permanent set of the Space Shuttle Thermal Protection System Reinforced Carbon–Carbon material by Lyle, Karen H., Fasanella, Edwin L.

“…The objective of this paper is to provide an interpretation and understanding of the permanent set (or deformation) phenomenon observed from debris impacts on…”
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X‐ray structure of putative acyl‐ACP desaturase DesA2 from Mycobacterium tuberculosis H37Rv by Dyer, David H., Lyle, Karen S., Rayment, Ivan, Fox, Brian G.

“…Genome sequencing showed that two proteins in Mycobacterium tuberculosis H37Rv contain the metal binding motif (D/E)X2HX∼100(D/E)X2H characteristic of the…”
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Microtubule dynamics regulation contributes to endothelial morphogenesis by Lyle, Karen S, Corleto, Jose A, Wittmann, Torsten

“…Because little is known how microtubules contribute to cell migration in a physiological three-dimensional environment, we analyzed microtubule function and…”
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Identification of the Binding Region of the [2Fe-2S] Ferredoxin in Stearoyl-Acyl Carrier Protein Desaturase:  Insight into the Catalytic Complex and Mechanism of Action by Sobrado, Pablo, Lyle, Karen S, Kaul, Steven P, Turco, Michelle M, Arabshahi, Ida, Marwah, Ashok, Fox, Brian G

“…Stearoyl-acyl carrier protein desaturase (Δ9D) catalyzes the O2 and 2e- dependent desaturation of stearoyl-acyl carrier protein (18:0-ACP) to yield oleoyl-ACP…”
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A computational approach for probabilistic analysis of water impact simulations by Horta, Lucas G., Mason, Brian H., Lyle, Karen H.

“…NASA's development of new concepts for the Crew Exploration Vehicle Orion presents many similar challenges to those worked in the 1960s during the Apollo…”
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Rapid-Mix and Chemical Quench Studies of Ferredoxin-Reduced Stearoyl-Acyl Carrier Protein Desaturase by Lyle, Karen S, Haas, Jeffrey A, Fox, Brian G

“…Stearoyl-ACP Δ9 desaturase (Δ9D) catalyzes the NADPH- and O2-dependent insertion of a cis double bond between the C9 and C10 positions of stearoyl-ACP…”
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Resonance Raman Studies of the Stoichiometric Catalytic Turnover of a Substrate−Stearoyl-Acyl Carrier Protein Δ9 Desaturase Complex by Lyle, Karen S, Möenne-Loccoz, Pierre, Ai, Jingyuan, Sanders-Loehr, Joann, Loehr, Thomas M, Fox, Brian G

“…Resonance Raman spectroscopy has been used to study the effects of substrate binding (stearoyl-acyl carrier protein, 18:0-ACP) on the diferric centers of…”
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Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors by Staben, Steven T, Feng, Jianwen A, Lyle, Karen, Belvin, Marcia, Boggs, Jason, Burch, Jason D, Chua, Ching-ching, Cui, Haifeng, DiPasquale, Antonio G, Friedman, Lori S, Heise, Christopher, Koeppen, Hartmut, Kotey, Adrian, Mintzer, Robert, Oh, Angela, Roberts, David Allen, Rouge, Lionel, Rudolph, Joachim, Tam, Christine, Wang, Weiru, Xiao, Yisong, Young, Amy, Zhang, Yamin, Hoeflich, Klaus P

“…Structure-based methods were used to design a potent and highly selective group II p21-activated kinase (PAK) inhibitor with a novel binding mode, compound 17…”
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SnapShot: Microtubule Regulators II by Lyle, Karen, Kumar, Praveen, Wittmann, Torsten

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SnapShot: Microtubule Regulators I by Lyle, Karen, Kumar, Praveen, Wittmann, Torsten

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PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition by Zhou, Wei, Jubb, Adrian M, Lyle, Karen, Xiao, Qian, Ong, Christy C, Desai, Rupal, Fu, Ling, Gnad, Florian, Song, Qinghua, Haverty, Peter M, Aust, Daniela, Grützmann, Robert, Romero, Mally, Totpal, Klara, Neve, Richard M, Yan, Yibing, Forrest, William F, Wang, Yulei, Raja, Rajiv, Pilarsky, Christian, de Jesus-Acosta, Ana, Belvin, Marcia, Friedman, Lori S, Merchant, Mark, Jaffee, Elizabeth M, Zheng, Lei, Koeppen, Hartmut, Hoeflich, Klaus P

“…Pancreatic adenocarcinoma (PDAC) is a major unmet medical need and a deeper understanding of molecular drivers is needed to advance therapeutic options for…”
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Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics by Gnad, Florian, Young, Amy, Zhou, Wei, Lyle, Karen, Ong, Christy C., Stokes, Matthew P., Silva, Jeffrey C., Belvin, Marcia, Friedman, Lori S., Koeppen, Hartmut, Minden, Audrey, Hoeflich, Klaus P.

“…Although K-Ras, Cdc42, and PAK4 signaling are commonly deregulated in cancer, only a few studies have sought to comprehensively examine the spectrum of…”
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Abstract A067: Targeting p21-activated kinases in breast cancer by Hoeflich, Klaus, Ong, Christy, Lyle, Karen, Jubb, Adrian, Zhou, Wei, Harris, Adrian, Belvin, Marcia, Friedman, Lori, Koeppen, Hartmut, Rudolph, Joachim, Staben, Steven

“…Abstract Luminal breast cancer is the most commonly diagnosed cancer worldwide and mechanisms of innate and acquired resistance are not yet well understood…”
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Abstract 4004: P21-activated kinases (PAKs) are novel therapeutic targets in human breast cancer by Ong, Christy, Jubb, Adrian, Haverty, Peter, Zhou, Wei, Lyle, Karen, Harris, Adrian, Belvin, Marcia, Friedman, Lori, Koeppen, Hartmut, Hoeflich, Klaus P.

“…Abstract P21-activated kinases (PAKs) are important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAKs…”
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GSK3[beta] phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment by Kumar, Praveen, Lyle, Karen S, Gierke, Sarah, Matov, Alexandre, Danuser, Gaudenz, Wittmann, Torsten

“…Polarity of the microtubule (MT) cytoskeleton is essential for many cell functions. Cytoplasmic linker-associated proteins (CLASPs) are MT-associated proteins…”
Get full text