Search Results - "Lyko, F"

Epigenetic cancer therapy: rationales, targets and drugs by Rius, M, Lyko, F

“…The fundamental role of altered epigenetic modification patterns in tumorigenesis establishes epigenetic regulatory enzymes as important targets for cancer…”
Get full text

Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia by Geyh, S, Rodríguez-Paredes, M, Jäger, P, Khandanpour, C, Cadeddu, R-P, Gutekunst, J, Wilk, C M, Fenk, R, Zilkens, C, Hermsen, D, Germing, U, Kobbe, G, Lyko, F, Haas, R, Schroeder, T

“…Hematopoietic insufficiency is the hallmark of acute myeloid leukemia (AML) and predisposes patients to life-threatening complications such as bleeding and…”
Get full text

RNA cytosine methylation analysis by bisulfite sequencing by Schaefer, Matthias, Pollex, Tim, Hanna, Katharina, Lyko, Frank

“…Covalent modifications of nucleic acids play an important role in regulating their functions. Among these modifications, (cytosine-5) DNA methylation is best…”
Get full text

Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells by Geyh, S, Öz, S, Cadeddu, R-P, Fröbel, J, Brückner, B, Kündgen, A, Fenk, R, Bruns, I, Zilkens, C, Hermsen, D, Gattermann, N, Kobbe, G, Germing, U, Lyko, F, Haas, R, Schroeder, T

“…Ineffective hematopoiesis is a major characteristic of myelodysplastic syndromes (MDS) causing relevant morbidity and mortality. Mesenchymal stromal cells…”
Get full text

Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription by Weber, B, Kimhi, S, Howard, G, Eden, A, Lyko, F

“…The cytosine analogues 5-azacytidine and 5-aza-2′-deoxycytidine are currently the most advanced drugs for epigenetic cancer therapy. Both drugs function as DNA…”
Get full text

Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a by Weis, B, Schmidt, J, Maamar, H, Raj, A, Lin, H, Tóth, C, Riedmann, K, Raddatz, G, Seitz, H-K, Ho, A D, Lyko, F, Linhart, H G

“…Aberrant de novo methylation of DNA is considered an important mediator of tumorigenesis. To investigate the role of de novo DNA methyltransferase 3a (Dnmt3a)…”
Get full text

DNA methylation in insects by Field, L.M, Lyko, F, Mandrioli, M, Prantera, G

“…Cytosine DNA methylation has been demonstrated in numerous eukaryotic organisms and has been shown to play an important role in human disease. The function of…”
Get full text

Epigenetic regulation in Drosophila by Lyko, F, Beisel, C, Marhold, J, Paro, R

“…Epigenetic regulation of gene transcription relies on molecular marks like DNA methylation or histone modifications. Here we review recent advances in our…”
Get more information

Conservation of DNA methylation in dipteran insects by Marhold, J, Rothe, N, Pauli, A, Mund, C, Kuehle, K, Brueckner, B, Lyko, F

“…DNA methylation is a central mechanism of epigenetic regulation. Whereas vertebrate DNA methylation requires at least four different DNA methyltransferases,…”
Get full text

719 Understanding the epigenetic interface between human skin and the environment by Grönniger, E., Falckenhayn, C., Völzke, H., Winnefeld, M., Lyko, F.

Get full text

imprinting element from the mouse H19 locus functions as a silencer in Drosophila by Lyko, F, Brenton, J.D, Surani, M.A, Paro, R

“…Genomic imprinting as originally described in Sciara is displayed by many organisms. In mammals, X-inactivation and the parent-of-origin-specific silencing of…”
Get full text

237 Cancer-associated fibroblasts with distinct origins and functions establish a pro-tumorigenic environment in squamous cell carcinoma by Paredes, M. Rodríguez, Schütz, S., Boldo, L. Solé, Lonsdorf, A.S., Lyko, F.

Get full text

DNA Methyltransferase Inhibitors and the Development of Epigenetic Cancer Therapies by Lyko, Frank, Brown, Robert

“…Epimutations, such as the hypermethylation and epigenetic silencing of tumor suppressor genes, play a role in the etiology of human cancers. In contrast to DNA…”
Get full text

469 Epigenomic characterization of non-melanoma skin cancer by Rodríguez Paredes, M., Solé Boldo, L., Raddatz, G., Gutekunst, J., Liberio, M., Mallm, J., Rippe, K., Lonsdorf, A.S., Lyko, F.

Get full text

Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines by STRESEMANN, Carlo, BRUECKNER, Bodo, MUSCH, Tanja, STOPPER, Helga, LYKO, Frank

“…DNA methyltransferase inhibitors represent promising new drugs for cancer therapies. The first of these compounds (5-azacytidine, Vidaza) has recently been…”
Get full text

Development DNA methylation in Drosophila melanogaster by Jaenisch, Rudolf, Lyko, Frank, Ramsahoye, Bernard H

“…Certain cytosine residues of eukaryotic DNA are methylated in inactive regions of the genome. For a long time the fruitfly Drosophila was thought to be an…”
Get full text

DNA methylation learns to fly by Lyko, Frank

“…For a long time, the fruit fly ( Drosophila melanogaster) was considered the archetypal organism that lives well without DNA methylation. However, two recent…”
Get full text

DNA methyltransferase inhibitors: old and new drugs for an epigenetic cancer therapy by Brueckner, Bodo, Lyko, Frank

“…The pharmacological inhibition of DNA methyltransferases provides novel opportunities for the therapy of human cancers. Several Phase III trials of DNA…”
Get full text

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases by BRUECKUER, Bodo, GARCIA BOY, Regine, SIEDLECKI, Pawel, MUSCH, Tanja, KLIEM, H. Christian, ZIELENKIEWICZ, Piotr, SUHAI, Sandor, WIESSLER, Manfred, LYKO, Frank

“…DNA methylation regulates gene expression in normal and malignant cells. The possibility to reactivate epigenetically silenced genes has generated considerable…”
Get full text

Two substrates are better than one: dual specificities for Dnmt2 methyltransferases by Jeltsch, Albert, Nellen, Wolfgang, Lyko, Frank

“…Dnmt2 enzymes have been widely conserved during evolution and contain all of the signature motifs of DNA (cytosine-5)-methyltransferases; however, the DNA…”
Get full text