Search Results - "Lykins, Joseph D."

Preliminary Analysis of Excess Mortality in India During the COVID-19 Pandemic by Leffler, Christopher T, Lykins V, Joseph D, Das, Saurav, Yang, Edward, Konda, Sneha

“…We studied all-cause mortality during the COVID-19 pandemic in 19 Indian states (population 1.27 billion). Excess mortality was calculated by comparison with…”
Get full text

The effect of delays in second-dose antibiotics on patients with severe sepsis and septic shock by Lykins V, Joseph D., Kuttab, Hani I., Rourke, Erron M., Hughes, Michelle D., Keast, Eric P., Kopec, Jason A., Ward, Brooke L., Pettit, Natasha N., Ward, Michael A.

“…Early antibiotics are fundamental to sepsis management. Second-dose antibiotic delays were associated with increased mortality in a recent study. Study…”
Get full text

Patients Who Decompensate and Trigger Rapid Response Immediately Upon Hospital Admission Have Higher Mortality Than Equivalent Patients Without Rapid Responses by Lykins V, Joseph D., Freedman, Matthew T., Zemore, Zachary, Sedhai, Yub Raj, Lubin, Shannon, Sessler, Curtis N., Hogan, Christopher, Kashiouris, Markos G.

“…Rapid response teams (RRTs) have impacted the management of decompensating patients, potentially improving mortality. Few studies address the significance of…”
Get full text

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations by El Bissati, Kamal, Redel, Henry, Ting, Li-Min, Lykins, Joseph D, McPhillie, Martin J, Upadhya, Rajendra, Woster, Patrick M, Yarlett, Nigel, Kim, Kami, Weiss, Louis M

“…Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite…”
Get full text

Blood Pressure Assessment and Treatment in the Observation Unit by Vitto, Christina M., Lykins V, Joseph D., Wiles-Lafayette, Hillary, Aurora, Taruna K.

“…Purpose of Review To review the pathophysiology, diagnosis, and the management of hypertension. Given the paucity of literature regarding the role of the…”
Get full text

Association of Country-wide Coronavirus Mortality with Demographics, Testing, Lockdowns, and Public Wearing of Masks by Leffler, Christopher T, Ing, Edsel, Lykins, Joseph D, Hogan, Matthew C, McKeown, Craig A, Grzybowski, Andrzej

“…We studied sources of variation between countries in per-capita mortality from COVID-19 (caused by the SARS-CoV-2 virus). Potential predictors of per-capita…”
Get full text

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii by Lykins, Joseph D, Filippova, Ekaterina V, Halavaty, Andrei S, Minasov, George, Zhou, Ying, Dubrovska, Ievgeniia, Flores, Kristin J, Shuvalova, Ludmilla A, Ruan, Jiapeng, El Bissati, Kamal, Dovgin, Sarah, Roberts, Craig W, Woods, Stuart, Moulton, Jon D, Moulton, Hong, McPhillie, Martin J, Muench, Stephen P, Fishwick, Colin W G, Sabini, Elisabetta, Shanmugam, Dhanasekaran, Roos, David S, McLeod, Rima, Anderson, Wayne F, Ngô, Huân M

“…, an Apicomplexan parasite, causes significant morbidity and mortality, including severe disease in immunocompromised hosts and devastating congenital disease,…”
Get full text

Evaluation and Predictors of Fluid Resuscitation in Patients With Severe Sepsis and Septic Shock by Kuttab, Hani I., Lykins, Joseph D., Hughes, Michelle D., Wroblewski, Kristen, Keast, Eric P., Kukoyi, Omobolawa, Kopec, Jason A., Hall, Stephen, Ward, Michael A.

“…OBJECTIVES:Rapid fluid resuscitation has become standard in sepsis care, despite “low-quality” evidence and absence of guidelines for populations “at risk” for…”
Get full text

Fluid Resuscitation in Septic Patients With Comorbid Heart Failure by Rourke, Erron M., Kuttab, Hani I., Lykins, Joseph D., Hughes, Michelle D., Keast, Eric P., Kopec, Jason A., Wroblewski, Kristen, Purakal, John, Ward, Michael A.

Get full text

The Effect of Fluid Resuscitation Timing in Early Sepsis Resuscitation by Kuttab, Hani I., Evans, Chad G., Lykins, Joseph D., Hughes, Michelle D., Kopec, Jason A., Hernandez, Michael A., Ward, Michael A.

“…Purpose The dose and timing of early fluid resuscitation in sepsis remains a debated topic. The objective of this study is to evaluate the effect of fluid…”
Get full text

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites by McPhillie, Martin J, Zhou, Ying, Hickman, Mark R, Gordon, James A, Weber, Christopher R, Li, Qigui, Lee, Patty J, Amporndanai, Kangsa, Johnson, Rachel M, Darby, Heather, Woods, Stuart, Li, Zhu-Hong, Priestley, Richard S, Ristroph, Kurt D, Biering, Scott B, El Bissati, Kamal, Hwang, Seungmin, Hakim, Farida Esaa, Dovgin, Sarah M, Lykins, Joseph D, Roberts, Lucy, Hargrave, Kerrie, Cong, Hua, Sinai, Anthony P, Muench, Stephen P, Dubey, Jitender P, Prud'homme, Robert K, Lorenzi, Hernan A, Biagini, Giancarlo A, Moreno, Silvia N, Roberts, Craig W, Antonyuk, Svetlana V, Fishwick, Colin W G, McLeod, Rima

“…Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation…”
Get full text

The Effect of Body Mass Index and Weight-Adjusted Fluid Dosing on Mortality in Sepsis by Ward, Michael A., Kuttab, Hani I., Lykins V, Joseph D., Wroblewski, Kristen, Hughes, Michelle D., Keast, Eric P., Kopec, Jason A., Rourke, Erron M., Purakal, John

“…Purpose: The Surviving Sepsis Campaign guidelines recommend 30 mL/kg of fluids within 3 hours (30by3) of sepsis-induced hypoperfusion, but a national mandate…”
Get full text

Patients Who Decompensate and Trigger Rapid Response Immediately Upon Hospital Admission Have Higher Mortality Than Equivalent Patients Without Rapid Responses by Lykins V, Joseph D., Freedman, Matthew T., Zemore, Zachary, Sedhai, Yub Raj, Lubin, Shannon, Sessler, Curtis N., Hogan, Christopher, Kashiouris, Markos G.

Get full text