Search Results - "Lyford, Timothy J"

Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic by Zhang, Xuqing, Luo, Mengyao, Dastagir, Shamael R., Nixon, Mellissa, Khamhoung, Annie, Schmidt, Andrea, Lee, Albert, Subbiah, Naren, McLaughlin, Douglas C., Moore, Christopher L., Gribble, Mary, Bayhi, Nicholas, Amin, Viral, Pepi, Ryan, Pawar, Sneha, Lyford, Timothy J., Soman, Vikram, Mellen, Jennifer, Carpenter, Christopher L., Turka, Laurence A., Wickham, Thomas J., Chen, Tiffany F.

“…Checkpoint inhibitors and T-cell therapies have highlighted the critical role of T cells in anti-cancer immunity. However, limitations associated with these…”
Get full text

Abstract 3256: RTX-IL-12, an allogeneic red cell therapeutic expressing IL-12, exhibits potent in vitro and in vivo activity and favorable safety profile by Dugast, Anne-Sophie, Hong, Enping, Hoover, Maegan, Bollampalli, Arjun, McLaughlin, Douglas C., Bhate, Omkar, Lyford, Timothy J., Nissen, Torben Straight, Carpenter, Christopher L., Wickham, Thomas J., Elloul, Sivan

“…Recombinant IL-12 is a potent cytokine that has held significant promise as an immunotherapeutic. In preclinical studies, recombinant IL-12 has impressive…”
Get full text

Abstract B062: Enabling the rapid generation of allogeneic artificial antigen presenting cell (aAPC) Red Cell Therapeutics with a loadable MHC system by Moore, Christopher L, Pawar, Sneha, Nixon, Mellissa, Lyford, Timothy J, McLaughlin, Douglas C, Dastagir, Shamael R, Bracha, Abigail, Melancon, Lori, Carpenter, Christopher L, Wickham, Thomas J, Chen, Tiffany F

“…Next generation sequencing technologies, coupled with personal neoantigen identification approaches, have significantly improved the capability to develop…”
Get full text