Search Results - "Lydon, J. P."

β-catenin mediates glandular formation and dysregulation of β-catenin induces hyperplasia formation in the murine uterus by Jeong, J-W, Lee, H S, Franco, H L, Broaddus, R R, Taketo, M M, Tsai, S Y, Lydon, J P, DeMayo, F J

“…Endometrioid adenocarcinoma is the most frequent form of endometrial cancer, usually developing in pre- and peri-menopausal women. β-catenin abnormalities are…”
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Progesterone-Regulated Genes in the Ovulation Process: ADAMTS-1 and Cathepsin L Proteases by Robker, R. L., Russell, D. L., Espey, L. L., Lydon, J. P., O'Malley, B. W., Richards, J. S.

“…Ovulation is a precisely timed process by which a mature oocyte is released from an ovarian follicle. This process is initiated by the pituitary surge of…”
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The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression by Kim, T H, Franco, H L, Jung, S Y, Qin, J, Broaddus, R R, Lydon, J P, Jeong, J -W

“…Ablation of Mig-6 in the murine uterus leads to the development of endometrial hyperplasia and estrogen-induced endometrial cancer. An additional endometrial…”
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Membrane progesterone receptors localization in the mouse spinal cord by Labombarda, F, Meffre, D, Delespierre, B, Krivokapic-Blondiaux, S, Chastre, A, Thomas, P, Pang, Y, Lydon, J.P, Gonzalez, S.L, De Nicola, A.F, Schumacher, M, Guennoun, R

“…Abstract The recent molecular cloning of membrane receptors for progesterone (mPRs) has tremendous implications for understanding the multiple actions of the…”
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Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities by Lydon, J P, DeMayo, F J, Funk, C R, Mani, S K, Hughes, A R, Montgomery, Jr, C A, Shyamala, G, Conneely, O M, O'Malley, B W

“…Although progesterone has been recognized as essential for the establishment and maintenance of pregnancy, this steroid hormone has been recently implicated to…”
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Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system by Kurita, T, Wang, Y Z, Donjacour, A A, Zhao, C, Lydon, J P, O'Malley, B W, Isaacs, J T, Dahiya, R, Cunha, G R

“…In males, androgens are essential in maintaining the integrity of the prostate. Androgen-ablation induces apoptosis of the prostatic epithelium. In females,…”
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Progesterone induction of calcitonin expression in the murine mammary gland by Ismail, PM, DeMayo, FJ, Amato, P, Lydon, JP

“…Progesterone, via its nuclear receptor, is mandatory not only for the induction and specification of mammary gland ductal side-branching and…”
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Progesterone enhances branching morphogenesis in the mouse mammary gland by increased expression of Msx2 by SATOH, K, HOVEY, R. C, MALEWSKI, T, WARRI, A, GOLDHAR, A. S, GINSBURG, E, SAITO, K, LYDON, J. P, VONDERHAAR, B. K

“…Branching morphogenesis within the peripubertal mouse mammary gland is directed by progesterone (P). A role for the homeobox-containing transcription factor,…”
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Molecular mechanisms involved in progesterone receptor regulation of uterine function by Lee, K., Jeong, J., Tsai, M.-J., Tsai, S., Lydon, J.P., DeMayo, F.J.

“…The ovarian steroid hormone progesterone is a major regulator of uterine function. The actions of this hormone is mediated through its cognate receptor, the…”
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Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells by Lee, I I, Maniar, K, Lydon, J P, Kim, J J

“…Progestins have long been used clinically for the treatment of endometrial cancers; however, the response rates to progestin therapy vary and the molecular…”
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Steroid hormone regulation of Clca3 expression in the murine uterus by Jeong, J-W, Lee, K Y, Lydon, J P, DeMayo, F J

“…Progesterone (P4) and its cognate receptor, the progesterone receptor (PGR), have important roles in the establishment and maintenance of pregnancy in the…”
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Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function by LYDON, J. P, GOUQING GE, KITTRELL, F. S, MEDINA, D, O'MALLEY, B. W

“…To define the functional relevance of progesterone-initiated intracellular signaling in mammary gland tumorigenesis, the progesterone receptor knockout (PRKO)…”
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Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice by Tu, Z, Wang, Q, Cui, T, Wang, J, Ran, H, Bao, H, Lu, J, Wang, B, Lydon, J P, DeMayo, F, Zhang, S, Kong, S, Wu, X, Wang, H

“…Successful embryo implantation requires functional luminal epithelia to establish uterine receptivity and blastocyst-uterine adhesion. During the configuration…”
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WNTs in the Neonatal Mouse Uterus: Potential Regulation of Endometrial Gland Development by Hayashi, Kanako, Yoshioka, Shin, Reardon, Sarah N, Rucker, Edmund B. III, Spencer, Thomas E, DeMayo, Francesco J, Lydon, John P, MacLean, James A. II

“…The WNTs are secreted proteins that control essential developmental processes, such as embryonic patterning, cell growth, migration, and differentiation. In…”
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Reproductive phenotypes of the progesterone receptor null mutant mouse by Lydon, John P., DeMayo, Francesco J., Conneely, Orla M., O'Malley, Bert W.

“…Although progesterone has been traditionally associated with the establishment and maintenance of mammalian pregnancy, a number of studies have implicated…”
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Paracrine Regulation of Epithelial Progesterone Receptor and Lactoferrin by Progesterone in the Mouse Uterus by KURITA, T, LEE, K.-J, COOKE, P. S, LYDON, J. P, CUNHA, G. R

“…The objective of this study was to determine whether uterine stromal and/or epithelial progesterone receptor (PR) is required for the antagonism by…”
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Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment by Stodden, G R, Lindberg, M E, King, M L, Paquet, M, MacLean, J A, Mann, J L, DeMayo, F J, Lydon, J P, Hayashi, K

“…Type II endometrial carcinomas (ECs) are estrogen independent, poorly differentiated tumors that behave in an aggressive manner. As TP53 mutation and CDH1…”
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Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform by Mulac-Jericevic, Biserka, Mullinax, Robert A., DeMayo, Francesco J., Lydon, John P., Conneely, Orla M.

“…Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR-A) and progesterone receptor-B (PR-B), that arise…”
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Regulation of Male Sexual Behavior by Progesterone Receptor, Sexual Experience, and Androgen by Phelps, Steven M., Lydon, John P., O'Malley, Bert W., Crews, David

“…Recent studies have demonstrated that physiological doses of progesterone may facilitate the androgen-dependent display of male sexual behavior in laboratory…”
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Defective in Mammary Gland Morphogenesis in Mice Lacking the Progesterone Receptor B Isoform by Mulac-Jericevic, Biserka, Lydon, John P., DeMayo, Francesco J., Conneely, Orla M.

“…Progesterone (P) regulates female reproduction via two nuclear receptors, PR-A and PR-B. Although both receptors display overlapping and distinct transcription…”
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