Search Results - "Lyda, Brent R."

Discovery and Synthesis of Hydroxy-l-Proline Blockers of the Neutral Amino Acid Transporters SLC1A4 (ASCT1) and SLC1A5 (ASCT2) by Lyda, Brent R, Leary, Gregory P, Farnsworth, Jill, Seaver, Benjamin, Silvius, Derek, Kavanaugh, Michael P, Esslinger, C Sean, Natale, Nicholas R

“…As a conformationally restricted amino acid, hydroxy-l-proline is a versatile scaffold for the synthesis of diverse multi-functionalized pyrrolidines for…”
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central cavity in trimeric glutamate transporters restricts ligand diffusion by Leary, Greg P, Holley, David C, Stone, Emily F, Lyda, Brent R, Kalachev, Leonid V, Kavanaugh, Michael P

“…A prominent aqueous cavity is formed by the junction of three identical subunits in the excitatory amino acid transporter (EAAT) family. To investigate the…”
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Structure-based discovery of selective positive allosteric modulators of antagonists for the M₂ muscarinic acetylcholine receptor by Korczynska, Magdalena, Clark, Mary J., Valant, Celine, Xu, Jun, Von Moo, Ee, Albold, Sabine, Weiss, Dahlia R., Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C., Lyda, Brent R., May, Lauren T., Baltos, Jo-Anne, Sexton, Patrick M., Kobilka, Brian K., Christopoulos, Arthur, Shoichet, Brian K., Sunahara, Roger K.

“…Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site…”
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In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes by Brea, Roberto J, Cole, Christian M, Lyda, Brent R, Ye, Libin, Prosser, R. Scott, Sunahara, Roger K, Devaraj, Neal K

“…Cell transmembrane receptors play a key role in the detection of environmental stimuli and control of intracellular communication. G protein-coupled receptors…”
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In Situ Reconstitution of the Adenosine A 2A Receptor in Spontaneously Formed Synthetic Liposomes by Brea, Roberto J, Cole, Christian M, Lyda, Brent R, Ye, Libin, Prosser, R Scott, Sunahara, Roger K, Devaraj, Neal K

“…Cell transmembrane receptors play a key role in the detection of environmental stimuli and control of intracellular communication. G protein-coupled receptors…”
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Structure-based discovery of selective positive allosteric modulators of antagonists for the M 2 muscarinic acetylcholine receptor by Korczynska, Magdalena, Clark, Mary J, Valant, Celine, Xu, Jun, Moo, Ee Von, Albold, Sabine, Weiss, Dahlia R, Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C, Lyda, Brent R, May, Lauren T, Baltos, Jo-Anne, Sexton, Patrick M, Kobilka, Brian K, Christopoulos, Arthur, Shoichet, Brian K, Sunahara, Roger K

“…Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site…”
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Discovery and Synthesis of Hydroxy-l-Proline Blockers of the Neutral Amino Acid Transporters SLC1A4 by Lyda, Brent R, Leary, Gregory P, Farnsworth, Jill, Seaver, Benjamin, Silvius, Derek, Kavanaugh, Michael P, Esslinger, C. Sean, Natale, Nicholas R

“…As a conformationally restricted amino acid, hydroxy-l-proline is a versatile scaffold for the synthesis of diverse multi-functionalized pyrrolidines for…”
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Structure-based discovery of selective positive allosteric modulators of antagonists for the M^sub 2^ muscarinic acetylcholine receptor by Korczynska, Magdalena, Clark, Mary J, Valant, Celine, Xu, Jun, Moo, Ee Von, Albold, Sabine, Weiss, Dahlia R, Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C, Lyda, Brent R, May, Lauren T, Baltos, Jo-Anne, Sexton, Patrick M, Kobilka, Brian K, Christopoulos, Arthur, Shoichet, Brian K, Sunahara, Roger K

“…Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site…”
Get full text