Search Results - "Lycke, N Y"

Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses by Bergqvist, P, Stensson, A, Hazanov, L, Holmberg, A, Mattsson, J, Mehr, R, Bemark, M, Lycke, N Y

“…Whereas gut IgA responses to the microbiota may be multi-centered and diverse, little is known about IgA responses to T-cell-dependent antigens following oral…”
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The regulation of gut mucosal IgA B-cell responses: recent developments by Lycke, N Y, Bemark, M

“…The majority of activated B cells differentiate into IgA plasma cells, with the gut being the largest producer of immunoglobulin in the body. Secretory IgA…”
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Cholera toxin adjuvant promotes a balanced Th1/Th2/Th17 response independently of IL-12 and IL-17 by acting on Gsα in CD11b+ DCs by Mattsson, J, Schön, K, Ekman, L, Fahlén-Yrlid, L, Yrlid, U, Lycke, N Y

“…Despite an extensive literature on the mechanism of action of cholera toxin (CT), we still lack critical information about how the toxin acts as an adjuvant…”
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Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization by VAJDY, M, LYCKE, N. Y

“…This study was conducted to investigate whether cholera toxin (CT), used as a mucosal adjuvant, would promote the development in mice of immunological memory…”
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IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection by Bromander, AK, Ekman, L, Kopf, M, Nedrud, JG, Lycke, NY

“…Using IL-6-deficient (IL-6 -/-) or wild-type mice, we investigated whether IL-6 is involved in the intestinal adjuvant activity of cholera toxin (CT) and to…”
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Interferon‐γ receptor‐deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance by KJERRULF, M., GRDIC, D., EKMAN, L., SCHÖN, K., VAJDY, M., LYCKE, N. Y.

“…Interferon‐γ (IFN‐γ) receptor knock‐out (IFN‐γR−/−) mice were used to analyse the role of IFN‐γ in mucosal immune responses following oral immunization. We…”
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Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin- specific protective immunity despite normal gut mucosal IgA differentiation by Hornquist, CE, Ekman, L, Grdic, KD, Schon, K, Lycke, NY

“…Using normal and CD4 gene-targeted (CD4-/-) mice, we asked whether mucosal immune responses and IgA B cell differentiation require the presence of CD4+ T…”
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Cholera toxin promotes B cell isotype switching by two different mechanisms. cAMP induction augments germ-line Ig H-chain RNA transcripts whereas membrane ganglioside GM1-receptor binding enhances later events in differentiation by Lycke, NY

“…In a recent study we provided evidence that isotype switching in LPS-stimulated murine B cells was greatly enhanced by cholera toxin (CT). We found that CT…”
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Impaired CD40‐Signalling in CD19‐Deficient Mice Selectively Affects Th2‐Dependent Isotype Switching by Gärdby, E., Chen, X.‐J., Lycke, N. Y.

“…Activation of B lymphocytes involves binding of antigen to the specific receptor and signalling through several membrane coreceptors, of which CD19 has been…”
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Antigen-specific and polyclonal CD4+ lamina propria T-cell lines phenotypic and functional characterization by HARRIMAN, G. R, HORNQVIST, E, LYCKE, N. Y

“…Surface phenotype and function of lamina propria CD4+ T cells have been evaluated. In addition, long-term, antigen-specific and polyclonal lamina propria CD4+…”
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Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin adjuvant by Sjöblom-Hallén, A, Marklund, U, Nerstedt, A, Schön, K, Ekman, L, Bergqvist, P, Löwenadler, B, Lycke, N Y

“…Earlier studies have reported on both proinflammatory and anti-inflammatory activities of cholera toxin (CT). As CT is a powerful adjuvant, we were interested…”
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Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit by Agren, LC, Ekman, L, Lowenadler, B, Lycke, NY

“…Cholera toxin (CT) is an exceptionally potent adjuvant but, unfortunately, also very toxic. Here we present a powerful new approach to separate toxicity from…”
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Adjuvanticity of the Cholera Toxin A1-Based Gene Fusion Protein, CTA1-DD, Is Critically Dependent on the ADP-Ribosyltransferase and Ig-Binding Activity by Agren, Lena C, Ekman, Lena, Lowenadler, Bjorn, Nedrud, John G, Lycke, Nils Y

“…The ADP-ribosylating enterotoxins, cholera toxin (CT) and Escherichia coli heat-labile toxin, are among the most powerful immunogens and adjuvants yet…”
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Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice by Gärdby, E, Lane, P, Lycke, N Y

“…The block in the CD80/CD86-CD28/CTLA-4 pathway in CTLA4-H gamma 1 transgenic (Tg) mice results in strongly impaired systemic IgG immunity and failure to…”
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The level of protection against rotavirus shedding in mice following immunization with a chimeric VP6 protein is dependent on the route and the coadministered adjuvant by Choi, Anthony H., McNeal, Monica M., Flint, Jason A., Basu, Mitali, Lycke, Nils Y., Clements, John D., Bean, Judy A., Davis, Heather L., McCluskie, Michael J., VanCott, John L., Ward, Richard L.

“…Intranasal (i.n.) immunization of BALB/c mice with chimeric murine rotavirus EDIM (epizootic diarrhea of infant mice) VP6 and attenuated E. coli heat-labile…”
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CD19‐deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA‐isotype switching in Peyer's patches by Gärdby, Eva, Lycke, Nils Y.

“…CD19 exhibits a critical role as a response regulator in B cells, influencing activation, differentiation and survival. Accordingly, CD19‐deficient mice…”
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Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells by Mathew, Nimitha R., Jayanthan, Jayalal K., Smirnov, Ilya V., Robinson, Jonathan L., Axelsson, Hannes, Nakka, Sravya S., Emmanouilidi, Aikaterini, Czarnewski, Paulo, Yewdell, William T., Schön, Karin, Lebrero-Fernández, Cristina, Bernasconi, Valentina, Rodin, William, Harandi, Ali M., Lycke, Nils, Borcherding, Nicholas, Yewdell, Jonathan W., Greiff, Victor, Bemark, Mats, Angeletti, Davide

“…B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, clonal proliferation, and…”
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Lack of Local Suppression in Orally Tolerant CD8-Deficient Mice Reveals a Critical Regulatory Role of CD8+ T Cells in the Normal Gut Mucosa by Grdic, Dubravka, Hornquist, Elisabeth, Kjerrulf, Martin, Lycke, Nils Y

“…We found that feeding keyhole limpet hemocyanin (KLH) to CD8-deficient (CD8-/-) mice induced oral tolerance that was comparable in both magnitude and quality…”
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Mucosal Vaccine Development Based on Liposome Technology by Höök, Fredrik, Bally, Marta, Norling, Karin, Bernasconi, Valentina, Lycke, Nils Y.

“…Immune protection against infectious diseases is most effective if located at the portal of entry of the pathogen. Hence, there is an increasing demand for…”
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A vaccine combination of lipid nanoparticles and a cholera toxin adjuvant derivative greatly improves lung protection against influenza virus infection by Bernasconi, Valentina, Norling, Karin, Gribonika, Inta, Ong, Li Ching, Burazerovic, Sabina, Parveen, Nagma, Schön, Karin, Stensson, Anneli, Bally, Marta, Larson, Göran, Höök, Fredrik, Lycke, Nils

“…This is a proof-of-principle study demonstrating that the combination of a cholera toxin derived adjuvant, CTA1-DD, and lipid nanoparticles (LNP) can…”
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