Search Results - "Lycke, N"

The regulation of gut mucosal IgA B-cell responses: recent developments by Lycke, N Y, Bemark, M

“…The majority of activated B cells differentiate into IgA plasma cells, with the gut being the largest producer of immunoglobulin in the body. Secretory IgA…”
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M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection by Eliasson, D G, Omokanye, A, Schön, K, Wenzel, U A, Bernasconi, V, Bemark, M, Kolpe, A, El Bakkouri, K, Ysenbaert, T, Deng, L, Fiers, W, Saelens, X, Lycke, N

“…Matrix protein 2 ectodomain (M2e) is considered an attractive component of a broadly protective, universal influenza A vaccine. Here we challenge the canonical…”
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Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses by Bergqvist, P, Stensson, A, Hazanov, L, Holmberg, A, Mattsson, J, Mehr, R, Bemark, M, Lycke, N Y

“…Whereas gut IgA responses to the microbiota may be multi-centered and diverse, little is known about IgA responses to T-cell-dependent antigens following oral…”
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Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins by Lycke, N, Bemark, M

“…The ultimate goal for vaccination is to stimulate protective immunological memory. Protection against infectious diseases not only relies on the magnitude of…”
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Cholera toxin adjuvant promotes a balanced Th1/Th2/Th17 response independently of IL-12 and IL-17 by acting on Gsα in CD11b+ DCs by Mattsson, J, Schön, K, Ekman, L, Fahlén-Yrlid, L, Yrlid, U, Lycke, N Y

“…Despite an extensive literature on the mechanism of action of cholera toxin (CT), we still lack critical information about how the toxin acts as an adjuvant…”
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Per Brandtzaeg: patron of mucosal immunology by Sollid, L M, Lycke, N

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The immune complex CTA1-DD/IgG adjuvant specifically targets connective tissue mast cells through FcγRIIIA and augments anti-HPV immunity after nasal immunization by Fang, Y, Zhang, T, Lidell, L, Xu, X, Lycke, N, Xiang, Z

“…We have previously reported that CTA1-DD/IgG immune complexes augment antibody responses in a mast cell–dependent manner following intranasal (IN)…”
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Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis by Lycke, J N, Karlsson, J-E, Andersen, O, Rosengren, L E

“…The neurofilament protein is a major structural protein of neurons and a marker for axonal damage. The concentrations of the light subunit of the neurofilament…”
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Immune modulation by a tolerogenic myelin oligodendrocyte glycoprotein (MOG)10–60 containing fusion protein in the marmoset experimental autoimmune encephalomyelitis model by Kap, Y. S., Driel, N., Arends, R., Rouwendal, G., Verolin, M., Blezer, E., Lycke, N., Hart, B. A.

“…Summary Current therapies for multiple sclerosis (MS), a chronic autoimmune neuroinflammatory disease, mostly target general cell populations or immune…”
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Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response by Johansson, M, Schön, K, Ward, M, Lycke, N

“…Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load by Mohammadi, M, Nedrud, J, Redline, R, Lycke, N, Czinn, SJ

“…BACKGROUND & AIMS: Previous findings suggest that TH1 cellular immune responses contribute to Helicobacter-associated gastritis. To further investigate this…”
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The CTA1-DD vaccine adjuvant binds to human B cells and potentiates their T cell stimulating ability by Eriksson, A, Lycke, N

“…The present study demonstrates that the novel CTA1-DD-adjuvant, which combines the full enzymatic activity of the A1 subunit of cholera toxin (CT) with an…”
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Mucosal immunization of piglets with purified F18 fimbriae does not protect against F18 + Escherichia coli infection by Verdonck, F., Tiels, P., van Gog, K., Goddeeris, B.M., Lycke, N., Clements, J., Cox, E.

“…Post-weaning diarrhoea and oedema disease in weaned piglets are caused by infection with F4 + or F18 + Escherichia coli strains. There is no commercial vaccine…”
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Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells by Lefrançois, L, Lycke, N

“…The intestinal mucosal immune system is composed of three major lymphoid areas: the lamina propria (LP), which lies just underneath the basement membrane in…”
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Immunological memory in B‐cell‐deficient mice conveys long‐lasting protection against genital tract infection with Chlamydia trachomatis by rapid recruitment of T cells by Johansson, M., Lycke, N.

“…Summary The role of antibodies and antigen deposition for the development of immunological memory has been incompletely investigated. We addressed whether…”
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The Nontoxic CTA1‐DD Adjuvant Enhances Protective Immunity Against Helicobacter pylori Infection Following Mucosal Immunization by Akhiani, A. A., Stensson, A., Schön, K., Lycke, N.

“…Safe and efficacious adjuvants are much needed to facilitate the development of mucosal vaccines. Here, we have asked whether our nontoxic vaccine adjuvant,…”
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Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin adjuvant by Sjöblom-Hallén, A, Marklund, U, Nerstedt, A, Schön, K, Ekman, L, Bergqvist, P, Löwenadler, B, Lycke, N Y

“…Earlier studies have reported on both proinflammatory and anti-inflammatory activities of cholera toxin (CT). As CT is a powerful adjuvant, we were interested…”
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Impaired mucosal immune responses in interleukin 4-targeted mice by Vajdy, M, Kosco-Vilbois, M H, Kopf, M, Köhler, G, Lycke, N

“…Interleukin 4-targeted (IL-4-/-) mice are defective in T helper (Th)2 cytokine production as determined after nematode infection. As Th2 cells appear to be…”
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Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens by LYCKE, N, HOLMGREN, J

“…There is a great need for substances that can act as adjuvants on local mucosal immune responses to perorally (p.o.) administered immunogens and which could be…”
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Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization by VAJDY, M, LYCKE, N. Y

“…This study was conducted to investigate whether cholera toxin (CT), used as a mucosal adjuvant, would promote the development in mice of immunological memory…”
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