Search Results - "Lycas, Matthew D."

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains by Rahbek-Clemmensen, Troels, Lycas, Matthew D., Erlendsson, Simon, Eriksen, Jacob, Apuschkin, Mia, Vilhardt, Frederik, Jørgensen, Trine N., Hansen, Freja H., Gether, Ulrik

“…Dopamine regulates reward, cognition, and locomotor functions. By mediating rapid reuptake of extracellular dopamine, the dopamine transporter is critical for…”
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A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data by Ejdrup, Aske L., Lycas, Matthew D., Lorenzen, Niels, Konomi, Ainoa, Herborg, Freja, Madsen, Kenneth L., Gether, Ulrik

“…Dual-color single-molecule localization microscopy (SMLM) provides unprecedented possibilities for detailed studies of colocalization of different molecular…”
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Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis by Andersen, Rita C, Schmidt, Jan H, Rombach, Joscha, Lycas, Matthew D, Christensen, Nikolaj R, Lund, Viktor K, Stapleton, Donnie S, Pedersen, Signe S, Olsen, Mathias A, Stoklund, Mikkel, Noes-Holt, Gith, Nielsen, Tommas Te, Keller, Mark P, Jansen, Anna M, Herlo, Rasmus, Pietropaolo, Massimo, Simonsen, Jens B, Kjærulff, Ole, Holst, Birgitte, Attie, Alan D, Gether, Ulrik, Madsen, Kenneth L

“…Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling…”
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Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs by Christiansen, Line I, Ventura, Gemma C, Holmqvist, Bo, Aasmul-Olsen, Karoline, Lindholm, Sandy E H, Lycas, Matthew D, Mori, Yuki, Secher, Jan Bojsen-Møller, Burrin, Douglas G, Thymann, Thomas, Sangild, Per T, Pankratova, Stanislava

“…Preterm infants have increased risk of impaired neurodevelopment to which reduced systemic levels of insulin-like growth factor 1 (IGF-1) in the weeks after…”
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An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1 by Herlo, Rasmus, Lund, Viktor K., Lycas, Matthew D., Jansen, Anna M., Khelashvili, George, Andersen, Rita C., Bhatia, Vikram, Pedersen, Thomas S., Albornoz, Pedro B.C., Johner, Niklaus, Ammendrup-Johnsen, Ina, Christensen, Nikolaj R., Erlendsson, Simon, Stoklund, Mikkel, Larsen, Jannik B., Weinstein, Harel, Kjærulff, Ole, Stamou, Dimitrios, Gether, Ulrik, Madsen, Kenneth L.

“…BAR domains are dimeric protein modules that sense, induce, and stabilize lipid membrane curvature. Here, we show that membrane curvature sensing (MCS) directs…”
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Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native Aβ oligomers to rats by Baerends, Eva, Soud, Katia, Folke, Jonas, Pedersen, Anna-Kathrine, Henmar, Simon, Konrad, Lisa, Lycas, Matthew D, Mori, Yuki, Pakkenberg, Bente, Woldbye, David P D, Dmytriyeva, Oksana, Pankratova, Stanislava

“…Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease characterized by the accumulation of aggregated amyloid beta (Aβ) and…”
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Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease by Herborg, Freja, Jensen, Kathrine L, Tolstoy, Sasha, Arends, Natascha V, Posselt, Leonie P, Shekar, Aparna, Aguilar, Jenny I, Lund, Viktor K, Erreger, Kevin, Rickhag, Mattias, Lycas, Matthew D, Lonsdale, Markus N, Rahbek-Clemmensen, Troels, Sørensen, Andreas T, Newman, Amy H, Løkkegaard, Annemette, Kjærulff, Ole, Werge, Thomas, Møller, Lisbeth B, Matthies, Heinrich Jg, Galli, Aurelio, Hjermind, Lena E, Gether, Ulrik

“…Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular…”
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DNA-PAINT adaptors make for efficient multiplexing by Lycas, Matthew D., Manley, Suliana

“…Multiplexed super-resolution imaging offers a route to spatial proteomics; however, time-efficient mapping of many protein species has been challenging. Two…”
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Behavioral encoding across timescales by region-specific dopamine dynamics by Jørgensen, Søren H, Ejdrup, Aske L, Lycas, Matthew D, Posselt, Leonie P, Madsen, Kenneth L, Tian, Lin, Dreyer, Jakob K, Herborg, Freja, Sørensen, Andreas T, Gether, Ulrik

“…The dorsal (DS) and ventral striatum (VS) receive dopaminergic projections that control motor functions and reward-related behavior. It remains poorly…”
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Wheel running exercise attenuates vulnerability to self-administer nicotine in rats by Sanchez, Victoria, Lycas, Matthew D, Lynch, Wendy J, Brunzell, Darlene H

“…Highlights • Exercise prevents acquisition of nicotine self-administration in adolescent rats. • Acquisition rates are not affected by access to locked running…”
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Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity by Lycas, Matthew D., Ejdrup, Aske L., Sørensen, Andreas T., Haahr, Nicolai O., Jørgensen, Søren H., Guthrie, Daryl A., Støier, Jonatan F., Werner, Christian, Newman, Amy Hauck, Sauer, Markus, Herborg, Freja, Gether, Ulrik

“…The nanoscopic organization and regulation of individual molecular components in presynaptic varicosities of neurons releasing modulatory volume…”
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Disruption of the PDZ domain–binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation by Sørensen, Gunnar, Rickhag, Mattias, Leo, Damiana, Lycas, Matthew D., Ridderstrøm, Pernille Herrstedt, Weikop, Pia, Lilja, Jamila H., Rifes, Pedro, Herborg, Freja, Woldbye, David, Wörtwein, Gitta, Gainetdinov, Raul R., Fink-Jensen, Anders, Gether, Ulrik

“…The dopamine (DA) transporter (DAT) is part of a presynaptic multiprotein network involving interactions with scaffold proteins via its C-terminal PDZ…”
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Within-Mice Comparison of Microdialysis and Fiber Photometry-Recorded Dopamine Biosensor during Amphetamine Response by Ejdrup, Aske L., Wellbourne-Wood, Joel, Dreyer, Jakob K., Guldhammer, Nina, Lycas, Matthew D., Gether, Ulrik, Hall, Benjamin J., Sørensen, Gunnar

“…A fundamental concept in neuroscience is the transmission of information between neurons via neurotransmitters, -modulators, and -peptides. For the past…”
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Diminished Role of Dopamine D1-Receptor Signaling with the Development of an Addicted Phenotype in Rats by Ramôa, Carolina P, Doyle, Susan E, Lycas, Matthew D, Chernau, Andrea K, Lynch, Wendy J

“…Background Although considerable evidence implicates dopamine D1-receptor signaling in the nucleus accumbens in motivation for cocaine during early stages of…”
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Disruption of hippocampal synaptic transmission and long-term potentiation by psychoactive synthetic cannabinoid 'Spice' compounds: comparison with Δ 9 -tetrahydrocannabinol by Hoffman, Alexander F, Lycas, Matthew D, Kaczmarzyk, Jakub R, Spivak, Charles E, Baumann, Michael H, Lupica, Carl R

“…There has been a marked increase in the availability of synthetic drugs designed to mimic the effects of marijuana. These cannabimimetic drugs, sold illicitly…”
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Disruption of hippocampal synaptic transmission and long‐term potentiation by psychoactive synthetic cannabinoid ‘Spice’ compounds: comparison with Δ9‐tetrahydrocannabinol by Hoffman, Alexander F., Lycas, Matthew D., Kaczmarzyk, Jakub R., Spivak, Charles E., Baumann, Michael H., Lupica, Carl R.

“…There has been a marked increase in the availability of synthetic drugs designed to mimic the effects of marijuana. These cannabimimetic drugs, sold illicitly…”
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Acute and Chronic Administration of a Low-Dose Combination of Topiramate and Ondansetron Reduces Ethanol's Reinforcing Effects in Male Alcohol Preferring (P) Rats by Moore, Catherine F., Lycas, Matthew D., Bond, Colin W., Johnson, Bankole A., Lynch, Wendy J.

“…Topiramate (a GABA/glutamate modulator) and ondansetron (a serotonin-3 antagonist) have shown promise as treatments for alcohol use disorders (AUDs), although…”
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Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis by Andersen, Rita C, Schmidt, Jan H, Rombach, Joscha, Lycas, Matthew D, Christensen, Nikolaj R, Lund, Viktor K, Stapleton, Donnie S, Pedersen, Signe S, Olsen, Mathias A, Stoklund, Mikkel, Noes-Holt, Gith, Nielsen, Tommas T E, Keller, Mark P, Jansen, Anna M, Herlo, Rasmus, Pietropaolo, Massimo, Simonsen, Jens B, Kjærulff, Ole, Holst, Birgitte, Attie, Alan D, Gether, Ulrik, Madsen, Kenneth L

“…Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling…”
Get full text

Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native A[beta] oligomers to rats by Baerends, Eva, Soud, Katia, Folke, Jonas, Pedersen, Anna-Kathrine, Henmar, Simon, Konrad, Lisa, Lycas, Matthew D, Mori, Yuki, Pakkenberg, Bente, Woldbye, David P. D, Dmytriyeva, Oksana, Pankratova, Stanislava

“…Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease characterized by the accumulation of aggregated amyloid beta (A[beta]) and…”
Get full text

Disruption of hippocampal synaptic transmission and long-term potentiation by psychoactive synthetic cannabinoid 'Spice' compounds: comparison with Delta super(9)-tetrahydrocannabinol by Hoffman, Alexander F, Lycas, Matthew D, Kaczmarzyk, Jakub R, Spivak, Charles E, Baumann, Michael H, Lupica, Carl R

“…There has been a marked increase in the availability of synthetic drugs designed to mimic the effects of marijuana. These cannabimimetic drugs, sold illicitly…”
Get full text