Search Results - "Lyapunova, N. A."
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Dosage effects of human ribosomal genes (rDNA) in health and disease
Published in Chromosome research (01-03-2019)“…Human ribosomal RNA genes encoding a pre-transcript of the three major ribosomal RNA (18S, 5.8S, and 28S rRNA) are tandemly repeated in human genome. Their…”
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Ribosomal genes in the human genome: Identification of four fractions, their organization in the nucleolus and metaphase chromosomes
Published in Russian journal of genetics (01-09-2010)“…Completion of human genome reading stimulated intense studies in the field of functional genomics and characterization of individual genomes. Of considerable…”
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The maternal effect in infantile autism: Elevated DNA damage degree in patients and their mothers
Published in Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry (01-10-2016)“…Infantile autism is a common disorder of mental development; besides hereditary predisposition, various environmental factors, including the condition of the…”
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Abundance of ribosomal RNA gene copies in the genomes of schizophrenia patients
Published in Schizophrenia research (01-07-2018)“…The ribosome is a critical component of the translation machinery. The key component of ribosomes is ribosomal RNA (rRNA). Dysregulation of rRNA biogenesis has…”
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Effects of the copy number of ribosomal genes (genes for rRNA) on viability of subjects with chromosomal abnormalities
Published in Gene (05-05-2017)“…The number of active ribosomal genes (AcRG) was evaluated in 172 carriers of chromosomal abnormalities (CA) such as Down's syndrome (DS), Robertsonian…”
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Blood serum DNA in patients with rheumatoid arthritis is considerably enriched with fragments of ribosomal repeats containing immunostimulatory CpG-motifs
Published in Bulletin of experimental biology and medicine (01-09-2006)“…We previously hypothesized that the sequence of transcribed region of human ribosomal repeats is selectively accumulated in circulating extracellular DNA due…”
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Cytokine Profiling of Subclinical Tick-Borne Infections in Humans
Published in Bulletin of experimental biology and medicine (01-03-2019)“…Over many years, tick-borne infections remain one of the most serious threats to human health worldwide. The immune response to these infections in a human…”
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Stimulatory effect of fragments from transcribed region of ribosomal repeat on human peripheral blood lymphocytes
Published in Bulletin of experimental biology and medicine (01-10-2006)“…Fragments from the transcribed region of the ribosomal repeat include considerable amounts of unmethylated CpG DNA motifs. These motifs activate immune cells…”
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PRELIMINARY RESULTS OF THE STUDY OF SUBCLINICAL INFECTIONS OF TICK-BORNE PATHOGENS IN BITTEN HUMANS
Published in Acta biomedica scientifica (01-02-2018)“…Background. Early detection of tick-borne pathogens in blood samples of infected people prevents the disease before clinical manifestations using antibiotic…”
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Water–Hexylene Glycol System as a Potential Medicinal Base
Published in Pharmaceutical chemistry journal (01-08-2013)“…Variation of the surface tension in a series of water–hexylene glycol (HG) two-component solvents was studied. It was shown that HG with its low value of…”
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Early and late responses to oxidative stress in human dermal fibroblasts of healthy donors and rheumatoid arthritis patients. Relationship between the cell death rate and the genomic dosage of active ribosomal genes
Published in Molecular biology (New York) (01-03-2005)“…A study was done regarding the effect of the oxidizing agent potassium chromate (K^sub 2^CrO^sub 4^, PC) on cultured dermal fibroblasts of a healthy donor and…”
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Quantitation of Repetitive Sequences in Human Genomic DNA and Detection of an Elevated Ribosomal Repeat Copy Number in Schizophrenia: The Results of Molecular and Cytogenetic Analyses
Published in Molecular biology (New York) (01-05-2003)“…A modified version of quantitating repetitive sequences in genomic DNA was developed to allow comparisons for numerous individual genomes and simultaneous…”
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Variation in Chromatin Structure of the rDNA Transcribed Region in Human Peripheral Blood Lymphocytes
Published in Molecular biology (New York) (01-01-2001)“…The rDNA transcribed region (TR) was tested for its accessibility for RsaI recognizing 15 TR sites, DNase I, and photoinducible arylazide…”
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Proteins tightly bound with rDNA transcribed regions in nuclei, nucleoids, and nucleoproteins of human lymphocytes: Isolation and characterization of candidate proteins
Published in Molecular biology (New York) (01-03-2000)“…Proteins tightly bound with the transcribed regions of human ribosomal genes protect them fromRsaI nuclease upon digestion of isolated lymphocyte nuclei,…”
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dynamics of blood biochemical parameters in an experiment with seven-day immersion
Published in Human physiology (2010)“…In an experiment with seven-day immersion, blood samples were taken from eight volunteers (21 to 26 years old) seven days prior to immersion, on days 3 and 7…”
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Premature centromere division of metaphase chromosomes in drug addicts and alcoholics
Published in Bulletin of experimental biology and medicine (01-09-1997)“…The study of metaphase chromosomes in peripheral blood lymphocytes from alcoholics and drug addicts revealed enhanced incidence of chromosomes with premature…”
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Ribosomal genes in inbred mouse strains: Interstrain and intrastrain variation of copy number and extent of methylation
Published in Russian journal of genetics (01-09-2007)“…Quantitative dot hybridization was used to estimate the rDNA copy number in brain tissues of five inbred mouse strains (AKR/JY, NZB/B1OrlY, CBA/CaLacY, 101/HY,…”
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Viability of carriers of chromosomal abnormalities depends on genomic dosage of active ribosomal genes (rRNA genes)
Published in Russian journal of genetics (01-06-2017)“…The genomic dosage of active (transcription-capable) ribosomal genes (AcRG) was determined in the genomes of 172 individuals, carriers of various chromosomal…”
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Methylation, copy number, and activity of ribosomal genes do not change after telomerization of human fibroblasts
Published in Doklady. Biochemistry and biophysics (01-09-2002)“…(ProQuest: Abstract omitted; see image)[PUBLICATION ABSTRACT]…”
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Pioneer of Molecular Genetics
Published in Molecular biology (New York) (01-11-2000)Get full text
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