Search Results - "Ly, Van T."

Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices by Ly, Van T., Brock, Barry

“…► LS/MS analysis of the precocene I metabolism in rat liver slices is shown. ► Cytochrome P450-mediated precocene I toxicity in rat liver slices is described…”
Get full text

The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone: A First in Class Epothilone B Analogue in Late-Phase Clinical Development by Goel, Sanjay, Cohen, Marvin, Cömezoglu, S Nilgün, Perrin, Lionel, André, François, Jayabalan, David, Iacono, Lisa, Comprelli, Adriana, Ly, Van T, Zhang, Donglu, Xu, Carrie, Humphreys, W Griffith, McDaid, Hayley, Goldberg, Gary, Horwitz, Susan B, Mani, Sridhar

“…Purpose: To determine if ixabepilone is a substrate for cytochrome P450 3A4 (CYP3A4) and if its metabolism by this cytochrome is clinically important, we did a…”
Get full text

Hepatocyte spheroids as a viable in vitro model for recapitulation of complex in vivo metabolism pathways of loratadine in humans by Chacko, Silvi A., Ly, Van T., Christopher, Lisa J., Gan, Jinping

“…Accurate prediction of in vivo metabolic pathways in humans can be challenging because in vitro liver matrices may fail to produce certain in vivo metabolites…”
Get full text

Biotransformation Profiling of [14C]Ixabepilone in Human Plasma, Urine and Feces Samples Using Accelerator Mass Spectrometry (AMS) by Nilgün Çömezoğlu, S., Ly, Van T., Zhang, Donglu, Griffith Humphreys, W., Bonacorsi, Samuel J., Everett, Donald W., Cohen, Marvin B., Gan, Jinping, Beumer, Jan H., Beijnen, Jos H., Schellens, Jan H.M., Lappin, Graham

“…Ixabepilone (BMS-247550, Ixempra™ is a semi-synthetic analog of the natural product epothilone B and marketed for its use in the treatment of cancer. A…”
Get full text

Metabolism and Excretion of an Oral Taxane Analog, [14C]3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in Rats and Dogs by LY, Van T, CACERES-CORTES, Janet, DONGLU ZHANG, HUMPHREYS, W. Griffith, EKHATO, Ihoezo V, EVERETT, Donald, NILGÜN CÖMEZOGLU, S

“…3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183) is a taxane analog that has the potential…”
Get full text

CYP3A4-Mediated Ester Cleavage as the Major Metabolic Pathway of the Oral Taxane 3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183) by DONGLU ZHANG, LY, Van T, LAGO, Michael, YUAN TIAN, JINPING GAN, HUMPHREYS, W. Griffith, NILGÜN CÖMEZOGLU, S

“…3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183) is an orally available taxane analog…”
Get full text

Development and evaluation of a multiple-plate fraction collector for sample processing: Application to radioprofiling in drug metabolism studies by Barros, Anthony, Ly, Van T., Chando, Theodore J., Ruan, Qian, Donenfeld, Scott L., Holub, David P., Christopher, Lisa J.

“…Microplate scintillation counters are utilized routinely in drug metabolism laboratories for the off-line radioanalysis of fractions collected during HPLC…”
Get full text

Efficacy of hand washing procedures on bacterial contamination of hydrogel contact lenses by LY, V. T, SIMMONS, P. A, EDRINGTON, T. B, WECHSLER, S, DE LAND, P. N

“…The effect of various hand washing regimens on transfer of bacterial contaminants from the hands to a hydrogel contact lenses was evaluated. Each of 47…”
Get full text

Asian Parents Living in the U.S. and Their Perspectives on Creativity and Problem Solving in Their Young Child by Ly, Van T

“…Past research asserts the extensiveness of multicultural experiences may be positively related to novel outcomes and creativity supporting cognitive processes…”
Get full text

Metabolism and Excretion of an Oral Taxane Analog, [14C]3′-tert-Butyl-3′-N-tert-butyloxycarbonyl-4-deacetyl-3′-dephenyl-3′-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in Rats and Dogs by Van T. Ly, Janet Caceres-Cortes, Donglu Zhang, W. Griffith Humphreys, Ihoezo V. Ekhato, Donald Everett, S. Nilgün Çömezoğlu

“…3′- tert -Butyl-3′- N-tert -butyloxycarbonyl-4-deacetyl-3′-dephenyl-3′- N -debenzoyl-4- O -methoxy-paclitaxel (BMS-275183) is a taxane analog that has…”
Get full text

CYP3A4-Mediated Ester Cleavage as the Major Metabolic Pathway of the Oral Taxane 3′-tert-Butyl-3′-N-tert-butyloxycarbonyl-4-deacetyl-3′-dephenyl-3′-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183) by Donglu Zhang, Van T. Ly, Michael Lago, Yuan Tian, Jinping Gan, W. Griffith Humphreys, S. Nilgün Çömezoğlu

“…3′- tert -Butyl-3′- N - tert -butyloxycarbonyl-4-deacetyl-3′-dephenyl-3′- N -debenzoyl-4- O -methoxycarbonyl-paclitaxel (BMS-275183) is an orally…”
Get full text

UNILATERAL STEEPENING OF THE SUPERIOR CORNEA: A CASE REPORT: Poster # 1 (CL-129) by Ly, Van T., Edrington, Timothy B.

Get full text

THE EFFICACY OF HAND-WASHING PROCEDURES ON MICROBIAL CONTAMINATION OF HYDROGEL CONTACT LENSES: 2:40 pm (CL-313) by Ly, Van T., Simmons, Peter A., Edrington, Timothy B., Wechsler, Sheldon, DeLand, Paul N.

Get full text