Search Results - "Ly, Neang S."

Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling by Bulitta, Jürgen B, Ly, Neang S, Landersdorfer, Cornelia B, Wanigaratne, Nicholin A, Velkov, Tony, Yadav, Rajbharan, Oliver, Antonio, Martin, Lisandra, Shin, Beom Soo, Forrest, Alan, Tsuji, Brian T

“…Bacterial resistance is among the most serious threats to human health globally, and many bacterial isolates have emerged that are resistant to all antibiotics…”
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Quantifying Subpopulation Synergy for Antibiotic Combinations via Mechanism-Based Modeling and a Sequential Dosing Design by Landersdorfer, Cornelia B, Ly, Neang S, Xu, Hongmei, Tsuji, Brian T, Bulitta, Jürgen B

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Attenuation of Colistin Bactericidal Activity by High Inoculum of Pseudomonas aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model by BULITTA, Jürgen B, YANG, Jenny C, YOHONN, Liliana, LY, Neang S, BROWN, Silvia V, D'HONDT, Rebecca E, JUSKO, William J, FORREST, Alan, TSUJI, Brian T

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New Dosing Strategies for an Old Antibiotic: Pharmacodynamics of Front-Loaded Regimens of Colistin at Simulated Pharmacokinetics in Patients with Kidney or Liver Disease by RAO, Gauri G, LY, Neang S, TSUJI, Brian T, HAAS, Curtis E, GARONZIK, Samira, FORREST, Alan, BULITTA, Jurgen B, KELCHLIN, Pamela A, HOLDEN, Patricia N, NATION, Roger L, JIAN LI

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Impact of Two-Component Regulatory Systems PhoP-PhoQ and PmrA-PmrB on Colistin Pharmacodynamics in Pseudomonas aeruginosa by Ly, Neang S, Yang, Jenny, Bulitta, Jurgen B, Tsuji, Brian T

“…The in vitro pharmacodynamics of colistin against Pseudomonas aeruginosa PAO1 wild-type and isogenic knockout strains of phoP and pmrA were evaluated. Colistin…”
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Development and Qualification of a Pharmacodynamic Model for the Pronounced Inoculum Effect of Ceftazidime against Pseudomonas aeruginosa by BULITTA, Jiirgen B, LY, Neang S, YANG, Jenny C, FORREST, Alan, JUSKO, William J, TSUJI, Brian T

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Population Pharmacokinetics and Exposure–Response Analysis for the Phase 3 COSMIC-311 Trial of Cabozantinib for Radioiodine-Refractory Differentiated Thyroid Cancer by Ly, Neang S., Li, Jing, Faggioni, Raffaella, Roskos, Lorin K., Brose, Marcia S.

“…Background and Objective In the USA, cabozantinib was approved for the treatment of patients aged ≥ 12 years with radioiodine-refractory differentiated thyroid…”
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Pharmacodynamic Variability beyond That Explained by MICs by Soon, Rachel L, Ly, Neang S, Rao, Gauri, Wollenberg, Lance, Yang, Kuo, Tsuji, Brian, Forrest, Alan

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Polymyxin B in combination with meropenem against carbapenemase-producing Klebsiella pneumoniae : pharmacodynamics and morphological changes by Sharma, Rajnikant, Patel, Saloni, Abboud, Cely, Diep, John, Ly, Neang S, Pogue, Jason M, Kaye, Keith S, Li, Jian, Rao, Gauri G

“…Highlights • Treatment options for KPC-producing Klebsiella pneumoniae are limited. • Polymyxin B (PMB) and meropenem (MEM) alone and in combination were…”
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Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies by Rao, Gauri G, Ly, Neang S, Bulitta, Jürgen B, Soon, Rachel L, San Roman, Marie D, Holden, Patricia N, Landersdorfer, Cornelia B, Nation, Roger L, Li, Jian, Forrest, Alan, Tsuji, Brian T

“…Polymyxin B is being increasingly utilized as a last resort against resistant Gram-negative bacteria. We examined the pharmacodynamics of novel dosing…”
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Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance by Ly, Neang S, Bulitta, Jürgen B, Rao, Gauri G, Landersdorfer, Cornelia B, Holden, Patricia N, Forrest, Alan, Bergen, Phillip J, Nation, Roger L, Li, Jian, Tsuji, Brian T

“…Colistin is an 'old' drug, which is being increasingly utilized due to limited therapeutic options. However, resistance emergence during monotherapy is…”
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Population Pharmacokinetics and Target Attainment of Ertapenem in Plasma and Tissue Assessed via Microdialysis in Morbidly Obese Patients after Laparoscopic Visceral Surgery by Wittau, Mathias, Paschke, Stephan, Kurlbaum, Max, Scheele, Jan, Ly, Neang S, Hemper, Evelyn, Kornmann, Marko, Henne-Bruns, Doris, Bulitta, Jürgen B

“…Ertapenem provides broad-spectrum activity against many pathogens, and its use is relevant for the prophylaxis and treatment of infections in morbidly obese…”
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Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii by Rao, Gauri G, Ly, Neang S, Diep, John, Forrest, Alan, Bulitta, Jürgen B, Holden, Patricia N, Nation, Roger L, Li, Jian, Tsuji, Brian T

“…Highlights • We investigated the pharmacodynamic activity of polymyxin B (PMB) and tigecycline comparing the differential killing of the combination against…”
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Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin by Bulman, Zackery P, Ly, Neang S, Lenhard, Justin R, Holden, Patricia N, Bulitta, Jürgen B, Tsuji, Brian T

“…The impact of quorum sensing on polymyxin and azithromycin pharmacodynamics was assessed in PAO1 and an isogenic / double knockout. For polymyxin B, greater…”
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Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa by Ly, Neang S, Bulman, Zackery P, Bulitta, Jürgen B, Baron, Christopher, Rao, Gauri G, Holden, Patricia N, Li, Jian, Sutton, Mark D, Tsuji, Brian T

“…Development of spontaneous mutations in Pseudomonas aeruginosa has been associated with antibiotic failure, leading to high rates of morbidity and mortality…”
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Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators by Bulman, Zackery P, Sutton, Mark D, Ly, Neang S, Bulitta, Jurgen B, Holden, Patricia N, Nation, Roger L, Li, Jian, Tsuji, Brian T

“…The interplay between polymyxin B pharmacodynamics and pathogenicity was examined in Pseudomonas aeruginosa PAO1 and isogenic DNA repair-deficient mutators…”
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Optimizing polymyxin antibiotics using combination therapy and mechanism-based models by Ly, Neang S

“…The emergence of multidrug-resistant (MDR) Gram-negative 'superbugs' coupled with a rapid decline in the development of new antibiotics has led to a serious,…”
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Optimizing polymyxin antibiotics using combination therapy and mechanism-based models by Ly, Neang S

“…The emergence of multidrug-resistant (MDR) Gram-negative 'superbugs' coupled with a rapid decline in the development of new antibiotics has led to a serious,…”
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