Search Results - "Ly, Hoa D."

MUTAGENESIS OF GLYCOSIDASES by Ly, Hoa D, Withers, Stephen G

“…Enzymatic hydrolysis of glycosides can occur by one of two elementary mechanisms identified by the stereochemical outcome of the reaction, inversion or…”
Get full text

How Does Alendronate Inhibit Protein-tyrosine Phosphatases? by Skorey, Kathryn, Ly, Hoa D., Kelly, John, Hammond, Mike, Ramachandran, Chidambaram, Huang, Zheng, Gresser, Michael J., Wang, Qingping

“…Alendronate (4-amino-1-hydroxybutylidene 1,1-bisphosphonate) is a drug used in the treatment of osteoporosis and other bone diseases. The inhibition of…”
Get full text

Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs by Strynadka, Natalie C.J, Persson, Karina, Ly, Hoa D, Dieckelmann, Manuela, Wakarchuk, Warren W, Withers, Stephen G

“…Many bacterial pathogens express lipooligosaccharides that mimic human cell surface glycoconjugates, enabling them to attach to host receptors and to evade the…”
Get full text

Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue by Lairson, Luke L, Chiu, Cecilia P C, Ly, Hoa D, He, Shouming, Wakarchuk, Warren W, Strynadka, Natalie C J, Withers, Stephen G

“…Lipopolysaccharyl-alpha-1,4-galactosyltransferase C (LgtC), a glycosyltransferase family 8 alpha-1,4-galactosyltransferase from Neisseria meningitidis,…”
Get full text

The synthesis, testing and use of 5-fluoro-α- d-galactosyl fluoride to trap an intermediate on green coffee bean α-galactosidase and identify the catalytic nucleophile by Ly, Hoa D, Howard, Steven, Shum, Kelly, He, Shouming, Zhu, Alex, Withers, Stephen G

“…5-Fluoro-α- d-galactopyranosyl fluoride was synthesized and its interaction with the active site of an α-galactosidase from green coffee bean ( Coffea…”
Get full text

Glycosyl Fluorides Can Function as Substrates for Nucleotide Phosphosugar-dependent Glycosyltransferases by Lougheed, B, Ly, H D, Wakarchuk, W W, Withers, S G

“…α-Galactosyl fluoride is shown to function as a substrate, in place of uridine-5′-diphosphogalactose, for the α-galactosyltransferase from Neisseria…”
Get full text

Mechanistic Studies of a Retaining α-Galactosyltransferase from Neisseria meningitidis by Ly, Hoa D, Lougheed, Brenda, Wakarchuk, Warren W, Withers, Stephen G

“…Lipopolysaccharyl α-galactosyltransferase from Neisseria meningitidis catalyzes the transfer of a galactosyl moiety from the activated donor UDP-Gal to…”
Get full text

Mechanistic Studies of a Retaining α-Galactosyltransferase from Neisseria meningitidis by Ly, Hoa D, Lougheed, Brenda, Wakarchuk, Warren W

Get full text

Intermediate Trapping on a Mutant Retaining α-Galactosyltransferase Identifies an Unexpected Aspartate Residue by Luke L. Lairson, Cecilia P. C. Chiu, Hoa D. Ly, Shouming He, Warren W. Wakarchuk, Natalie C. J. Strynadka, Stephen G. Withers

“…Lipopolysaccharyl-α-1,4-galactosyltransferase C (LgtC), a glycosyltransferase family 8 α-1,4-galactosyltransferase from Neisseria meningitidis , catalyzes…”
Get full text

Syntheses and kinetic evaluation of hydroxamate-based peptide inhibitors of glyoxalase I by Ly, Hoa D., Susan, L.Clugston, Sampson, Peter B., Honek, John F.

“…Hydroxamate-containing tripeptide analogs resembling a reactive intermediate in glyoxalase I catalysis were prepared by solution methods and were found to be…”
Get full text