Search Results - "Ly, Danith H."

In utero nanoparticle delivery for site-specific genome editing by Ricciardi, Adele S., Bahal, Raman, Farrelly, James S., Quijano, Elias, Bianchi, Anthony H., Luks, Valerie L., Putman, Rachael, López-Giráldez, Francesc, Coşkun, Süleyman, Song, Eric, Liu, Yanfeng, Hsieh, Wei-Che, Ly, Danith H., Stitelman, David H., Glazer, Peter M., Saltzman, W. Mark

“…Genetic diseases can be diagnosed early during pregnancy, but many monogenic disorders continue to cause considerable neonatal and pediatric morbidity and…”
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Electronic Barcoding of a Viral Gene at the Single-Molecule Level by Singer, Alon, Rapireddy, Srinivas, Ly, Danith H, Meller, Amit

“…A new single-molecule approach for rapid and purely electronic discrimination among similar genes is presented. Combining solid-state nanopores and γ-modified…”
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In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery by Bahal, Raman, Ali McNeer, Nicole, Quijano, Elias, Liu, Yanfeng, Sulkowski, Parker, Turchick, Audrey, Lu, Yi-Chien, Bhunia, Dinesh C., Manna, Arunava, Greiner, Dale L., Brehm, Michael A., Cheng, Christopher J., López-Giráldez, Francesc, Ricciardi, Adele, Beloor, Jagadish, Krause, Diane S., Kumar, Priti, Gallagher, Patrick G., Braddock, Demetrios T., Mark Saltzman, W., Ly, Danith H., Glazer, Peter M.

“…The blood disorder, β-thalassaemia, is considered an attractive target for gene correction. Site-specific triplex formation has been shown to induce DNA repair…”
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Gamma Peptide Nucleic Acids: As Orthogonal Nucleic Acid Recognition Codes for Organizing Molecular Self-Assembly by Sacui, Iulia, Hsieh, Wei-Che, Manna, Arunava, Sahu, Bichismita, Ly, Danith H

“…Nucleic acids are an attractive platform for organizing molecular self-assembly because of their specific nucleobase interactions and defined length scale…”
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Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy by Gupta, Anisha, Quijano, Elias, Liu, Yanfeng, Bahal, Raman, Scanlon, Susan E., Song, Eric, Hsieh, Wei-Che, Braddock, Demetrios E., Ly, Danith H., Saltzman, W. Mark, Glazer, Peter M.

“…MicroRNAs (miRs) are frequently overexpressed in human cancers. In particular, miR-210 is induced in hypoxic cells and acts to orchestrate the adaptation of…”
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β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid by Delgado, Evan, Bahal, Raman, Yang, Jing, Lee, Jung M, Ly, Danith H, Monga, Satdarshan P S

“…Hepatocellular cancer (HCC) is the third cause of death by cancer worldwide. In the current study we target β- catenin, an oncogene mutated and constitutively…”
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Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition by Bahal, Raman, Quijano, Elias, McNeer, Nicole A, Liu, Yanfeng, Bhunia, Dinesh C, Lopez-Giraldez, Francesco, Fields, Rachel J, Saltzman, William M, Ly, Danith H, Glazer, Peter M

“…Triplex-forming peptide nucleic acids (PNAs) facilitate gene editing by stimulating recombination of donor DNAs within genomic DNA via site-specific formation…”
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Shape selective bifacial recognition of double helical DNA by Thadke, Shivaji A., Hridya, V. M., Perera, J. Dinithi R., Gil, Roberto R., Mukherjee, Arnab, Ly, Danith H.

“…An impressive array of antigene approaches has been developed for recognition of double helical DNA over the past three decades; however, few have exploited…”
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Effect of Backbone Flexibility on Charge Transfer Rates in Peptide Nucleic Acid Duplexes by Wierzbinski, Emil, de Leon, Arnie, Yin, Xing, Balaeff, Alexander, Davis, Kathryn L, Reppireddy, Srinivas, Venkatramani, Ravindra, Keinan, Shahar, Ly, Danith H, Madrid, Marcela, Beratan, David N, Achim, Catalina, Waldeck, David H

“…Charge transfer (CT) properties are compared between peptide nucleic acid structures with an aminoethylglycine backbone (aeg-PNA) and those with a γ-methylated…”
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Mitotic Misregulation and Human Aging by Ly, Danith H., Lockhart, David J., Lerner, Richard A., Schultz, Peter G.

“…Messenger RNA levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria, a rare…”
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Loop and Backbone Modifications of Peptide Nucleic Acid Improve G-Quadruplex Binding Selectivity by Lusvarghi, Sabrina, Murphy, Connor T, Roy, Subhadeep, Tanious, Farial A, Sacui, Iulia, Wilson, W. David, Ly, Danith H, Armitage, Bruce A

“…Targeting guanine (G) quadruplex structures is an exciting new strategy with potential for controlling gene expression and designing anticancer agents…”
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Strand Invasion of DNA Quadruplexes by PNA: Comparison of Homologous and Complementary Hybridization by Gupta, Anisha, Lee, Ling-Ling, Roy, Subhadeep, Tanious, Farial A., Wilson, W. David, Ly, Danith H., Armitage, Bruce A.

“…Molecular recognition of DNA quadruplex structures is envisioned to be a strategy for regulating gene expression at the transcriptional level and for in situ…”
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Antitumor Effects of EGFR Antisense Guanidine-Based Peptide Nucleic Acids in Cancer Models by Thomas, Sufi M, Sahu, Bichismita, Rapireddy, Srinivas, Bahal, Raman, Wheeler, Sarah E, Procopio, Eva M, Kim, Joseph, Joyce, Sonali C, Contrucci, Sarah, Wang, Yun, Chiosea, Simion I, Lathrop, Kira L, Watkins, Simon, Grandis, Jennifer R, Armitage, Bruce A, Ly, Danith H

“…Peptide nucleic acids have emerged over the past two decades as a promising class of nucleic acid mimics because of their strong binding affinity and sequence…”
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Stereochemical conversion of nucleic acid circuits via strand displacement by Hsieh, Wei-Che, Martinez, Gustavo R., Wang, Ashley, Wu, Sharon F., Chamdia, Raunaq, Ly, Danith H.

“…Remarkable accomplishments demonstrating the importance of nucleic acids in molecular engineering and computation have been made over the past two decades…”
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Development of the Right- and Left-Handed Gamma Peptide Nucleic Acid Building Blocks for On-Resin Chemical Functionalization by Dhami, Isha, Thadke, Shivaji A., Ly, Danith H.

“…Gamma peptide nucleic acids (PNAs) are a promising class of nucleic acid mimics that adopt either a right- or left-handed helical motif as individual strands…”
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Novel Binding and Efficient Cellular Uptake of Guanidine-Based Peptide Nucleic Acids (GPNA) by Zhou, Peng, Wang, Miaomiao, Du, Lei, Fisher, Gregory W, Waggoner, Alan, Ly, Danith H

“…Incorporation of a guanidine functional group into the PNA backbone facilitates cellular uptake of PNA into mammalian cells with efficiency comparable to that…”
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Synthesis and Characterization of Conformationally Preorganized, (R)-Diethylene Glycol-Containing γ-Peptide Nucleic Acids with Superior Hybridization Properties and Water Solubility by Sahu, Bichismita, Sacui, Iulia, Rapireddy, Srinivas, Zanotti, Kimberly J, Bahal, Raman, Armitage, Bruce A, Ly, Danith H

“…Developed in the early 1990s, peptide nucleic acid (PNA) has emerged as a promising class of nucleic acid mimic because of its strong binding affinity and…”
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Strand Invasion of Mixed-Sequence, Double-Helical B-DNA by γ-Peptide Nucleic Acids Containing G-Clamp Nucleobases under Physiological Conditions by Rapireddy, Srinivas, Bahal, Raman, Ly, Danith H

“…Peptide nucleic acids (PNAs) make up the only class of nucleic acid mimics developed to date that has been shown to be capable of invading double-helical…”
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Cell-Permeable Peptide Nucleic Acid Designed to Bind to the 5‘-Untranslated Region of E-cadherin Transcript Induces Potent and Sequence-Specific Antisense Effects by Dragulescu-Andrasi, Anca, Rapireddy, Srinivas, He, Gaofei, Bhattacharya, Birendra, Hyldig-Nielsen, Jens J, Zon, Gerald, Ly, Danith H

“…Establishing a general and effective method for regulating gene expression in mammalian systems is important for many aspects of biological and biomedical…”
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A Robust Method for Preparing Optically Pure MiniPEG-Containing Gamma PNA Monomers by Hsieh, Wei-Che, Ly, Danith H

“…We report the syntheses of chemical building blocks of a particular class of chiral PNAs, called miniPEG-containing (R)-gamma PNAs (or (R)-MPγPNAs). The…”
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