Neutrophil extracellular traps and neutrophilic dermatosis: an update review

Neutrophil extracellular traps and neutrophilic dermatosis: an update review

Neutrophils have both antimicrobial ability and pathogenic effect in the immune system, neutrophil extracellular traps (NETs) formation is one of the representative behaviors of their dual role. NETs formation was triggered by pathogen-related components and pathogen non-related proteins as cytokine...

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Bibliographic Details
Published in:Cell death discovery Vol. 10; no. 1; p. 18
Main Authors: Li, Sheng, Ying, Shuni, Wang, Yuqian, Lv, Yelu, Qiao, Jianjun, Fang, Hong
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 10-01-2024
Springer Nature B.V
Nature Publishing Group
Subjects:
631/45/127/1213
631/80/304
Apoptosis
Behcet's syndrome
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Cycle Analysis
Dermis
Immune system
Leukocytes (neutrophilic)
Life Sciences
Neutrophils
Pathogenesis
Pathogenicity
Pathogens
Psoriasis
Pyoderma
Pyoderma gangrenosum
Review
Review Article
Skin diseases
Stem Cells
Stevens-Johnson syndrome
Sweet's syndrome
Toxic epidermal necrolysis
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Summary:Neutrophils have both antimicrobial ability and pathogenic effect in the immune system, neutrophil extracellular traps (NETs) formation is one of the representative behaviors of their dual role. NETs formation was triggered by pathogen-related components and pathogen non-related proteins as cytokines to exert its effector functions. Recent studies indicate that the pathogenicity of NETs contributed to several skin diseases such as psoriasis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and neutrophilic dermatosis. Especially in neutrophilic dermatosis, a heterogeneous group of inflammatory skin disorders characterized with sterile neutrophilic infiltrate on dermis, NETs formation was reported as the way of participation of neutrophils in the pathogenesis of these diseases. In this review, we describe the different processes of NETs formation, then summarized the most recent updates about the pathogenesis of neutrophilic dermatosis and the participation of NETs, including pyoderma gangrenosum and PAPA syndrome, Behçet syndrome, hidradenitis suppurativa, Sweet Syndrome, pustular dermatosis and other neutrophilic dermatosis. Furthermore, we discuss the link between NETs formation and the development of neutrophilic dermatosis.
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SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-023-01787-2