Search Results - "Lv, Binhua"

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Ascending Dose and Food Effect Study to Evaluate the Tolerance, Pharmacokinetics of Jaktinib, a New Selective Janus Kinase Inhibitor in Healthy Chinese Volunteers by Liu, Jingrui, Lv, Binhua, Yin, Hewen, Zhu, Xiaoxue, Wei, Haijing, Ding, Yanhua

“…Jaktinib is a novel selective janus kinase 1/2 inhibitor. The phase I first-in-human study evaluated the tolerance and pharmacokinetics of jaktinib in healthy…”
Get full text

A novel anti-LAG-3/TIGIT bispecific antibody exhibits potent anti-tumor efficacy in mouse models as monotherapy or in combination with PD-1 antibody by Dai, Tongcheng, Sun, Hao, Liban, Tyler, Vicente-Suarez, Ildefonso, Zhang, Bin, Song, Yongping, Jiang, Zhongxing, Yu, Jifeng, Sheng, Jackie, Lv, Binhua

“…We report the generation of a novel anti-LAG-3/TIGIT bispecific IgG4 antibody, ZGGS15, and evaluated its anti-tumor efficacy in mouse models as monotherapy or…”
Get full text

Design, Synthesis, and Biological Evaluation of Deuterated C‑Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes by Xu, Ge, Lv, Binhua, Roberge, Jacques Y, Xu, Baihua, Du, Jiyan, Dong, Jiajia, Chen, Yuanwei, Peng, Kun, Zhang, Lili, Tang, Xinxing, Feng, Yan, Xu, Min, Fu, Wei, Zhang, Wenbin, Zhu, Liangcheng, Deng, Zhongping, Sheng, Zelin, Welihinda, Ajith, Sun, Xun

“…SGLT2 inhibitors deuterated at sites susceptible to oxidative metabolism were found to have a slightly longer t max and half-life (t 1/2), dose-dependent…”
Get full text

Study on Typical Diarylurea Drugs or Derivatives in Cocrystallizing with Strong H‑Bond Acceptor DMSO by Li, Chengwei, Zhong, Jialiang, Liu, Baohu, Yang, Tao, Lv, Binhua, Luo, Youfu

“…Diarylureas are widely used in self-assembly and supramolecular chemistry owing to their outstanding characteristics as both H-bond donors and acceptors…”
Get full text

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA1c levels in db/db mice and prolongs the survival of stroke-prone rats by Zhang, Wenbin, Welihinda, Ajith, Mechanic, Jordan, Ding, Haifeng, Zhu, Liangcheng, Lu, Yuan, Deng, Zhongping, Sheng, Zelin, Lv, Binhua, Chen, Yuanwei, Roberge, Jacques Y., Seed, Brian, Wang, Yong-Xiang

Get full text

Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by Lv, Binhua, Xu, Baihua, Feng, Yan, Peng, Kun, Xu, Ge, Du, Jiyan, Zhang, Lili, Zhang, Wenbin, Zhang, Ting, Zhu, Liangcheng, Ding, Haifeng, Sheng, Zelin, Welihinda, Ajith, Seed, Brian, Chen, Yuanwei

“…The novel spiro[isobenzofuran-1,2′-pyran] structure is proved to be an effective scaffold for diversification of SGLT2 inhibitors and a number of compounds…”
Get full text

C-Aryl glucosides substituted at the 4′-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes by Xu, Baihua, Feng, Yan, Cheng, Huawei, Song, Yanli, Lv, Binhua, Wu, Yuelin, Wang, Congna, Li, Shengbin, Xu, Min, Du, Jiyan, Peng, Kun, Dong, Jiajia, Zhang, Wenbin, Zhang, Ting, Zhu, Liangcheng, Ding, Haifeng, Sheng, Zelin, Welihinda, Ajith, Roberge, Jacques Y., Seed, Brian, Chen, Yuanwei

“…A series of C-aryl glucosides with various substituents at the 4′-position of the distal aryl ring have been synthesized and evaluated for inhibition of hSGLT1…”
Get full text

O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by Xu, Baihua, Lv, Binhua, Feng, Yan, Xu, Ge, Du, Jiyan, Welihinda, Ajith, Sheng, Zelin, Seed, Brian, Chen, Yuanwei

“…Two series of O-spiro C-aryl glucosides have been synthesized and evaluated for inhibition of hSGLT1 and hSGLT2. Two series of O-spiro C-aryl glucosides were…”
Get full text

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by Xu, Baihua, Feng, Yan, Lv, Binhua, Xu, Ge, Zhang, Lili, Du, Jiyan, Peng, Kun, Xu, Min, Dong, Jiajia, Zhang, Wenbin, Zhang, Ting, Zhu, Liangcheng, Ding, Haifeng, Sheng, Zelin, Welihinda, Ajith, Seed, Brian, Chen, Yuanwei

“…A series of ortho-substituted C-aryl glucosides have been synthesized and evaluated for inhibition of hSGLT1 and hSGLT2. A series of 2-substituted C-aryl…”
Get full text

Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo by Pang, Xudong, Cui, Dawei, Lv, Binhua, Wang, Cheng-Yun

“…Directly targeted KRAS inhibitors are now facing resistance problems, which might be partially solved by the combination of SOS1 inhibitors with KRAS…”
Get full text

ZGGS15, a Novel IgG4 Bispecific Monoclonal Antibody Targeting Both LAG-3 and Tigit, Demonstrates Outstanding Anti-Tumor Activity and Can be Used As Monotherapy or in Combination with Anti-PD-1 Antibodies for Cancer Immunotherapy by Yu, Jifeng, Dai, Tongcheng, Sun, Hao, Zhang, Bin, Liban, Tyler, Ochoa, Jessica, Sheng, Jackie, Song, Yongping, Jiang, Zhongxing, Sheng, Zelin, Lv, Binhua

“…Background This study aims to evaluate the anti-tumor efficacy of ZGGS15, a novel IgG4 bispecific monoclonal antibody (BsAb) targeting TIGIT and LAG-3, for…”
Get full text

Abstract 1618: A highly selective and potent TLR8 agonist ZG0895 in preclinical studies of anti-tumor activities by Cui, Dawei, Liu, Ruifeng, Yang, Huanyi, Zhu, Bing, Sheng, Zelin, Lv, Binhua

“…Abstract Toll-like receptor 8 (TLR8) recognizes ssRNA fragments from pathogens and initiate both innate and adaptive immune responses. TLR8 activation can…”
Get full text

Abstract 2790: Preclinical studies of ZG19018, a novel irreversible covalent inhibitor of KRAS G12C, for the treatment of advanced non-small cell lung cancer and other solid tumors by Zhu, Bing, Cui, Dawei, Liu, Ruifeng, Feng, Weidong, Sheng, Zelin, Lv, Binhua

“…Abstract Growing evidences of covalent irreversible inhibitors in clinical treatments of solid tumors with KRAS G12C mutation have recently emerged after…”
Get full text

Abstract 2323: ZGGS18, a bispecific drug candidate of anti-VEGF and TGFbeta-trap, inhibiting tumor proliferation and improving tumor microenvironment with I/O therapy by Liu, Ruifeng, Suarez, Alfonso, Liban, Tyler, Zhang, Bin, Dai, Tongcheng, Karow, Margaret, Sheng, Jackie, Sheng, Zelin, Lv, Binhua, Zhu, Bing

“…Abstract ZGGS18 is a bifunctional fusion protein targeting both human vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β), which…”
Get full text

Abstract 6368: Preclinical pharmacology and safety studies of ZG005: an anti-PD-1/TIGIT bispecific mAb in a phase I clinical trial for advanced tumors by Zhu, Bing, Dai, Tongcheng, Liu, Ruifeng, Suarez, Alfonso, Liban, Tyler, Zhang, Bin, Karow, Margaret, Sheng, Jackie, Sheng, Zelin, Lv, Binhua

“…Abstract ZG005 is a humanized anti-PD-1/TIGIT bispecific antibody that effectively blocks the binding between PD-1 and TIGIT, on immune cells, with their…”
Get full text

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats by Zhang, Wenbin, Welihinda, Ajith, Mechanic, Jordan, Ding, Haifeng, Zhu, Liangcheng, Lu, Yuan, Deng, Zhongping, Sheng, Zelin, Lv, Binhua, Chen, Yuanwei, Roberge, Jacques Y, Seed, Brian, Wang, Yong-Xiang

“…Sodium glucose co-transporter 2 (SGLT2) is a renal type III integral membrane protein that co-transports sodium and glucose from filtrate to epithelium in the…”
Get full text

Conformationally Constrained Spiro C-Arylglucosides as Potent and Selective Renal Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors by Lv, Binhua, Feng, Yan, Dong, Jiajia, Xu, Min, Xu, Baihua, Zhang, Wenbin, Sheng, Zelin, Welihinda, Ajith, Seed, Brian, Chen, Yuanwei

“…Sodium glucose co‐transporter 2 (SGLT2) is an emerging target for the treatment of type 2 diabetes mellitus (DM2). Here, the synthesis and preliminary…”
Get full text

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA 1c levels in db/db mice and prolongs the survival of stroke-prone rats by Zhang, Wenbin, Welihinda, Ajith, Mechanic, Jordan, Ding, Haifeng, Zhu, Liangcheng, Lu, Yuan, Deng, Zhongping, Sheng, Zelin, Lv, Binhua, Chen, Yuanwei, Roberge, Jacques Y., Seed, Brian, Wang, Yong-Xiang

“…Sodium glucose co-transporter 2 (SGLT2) is a renal type III integral membrane protein that co-transports sodium and glucose from filtrate to epithelium in the…”
Get full text