Search Results - "Luzzatto, L."

G6PD deficiency and malaria selection by Luzzatto, L

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Rasburicase Therapy in the Context of G6PD Deficiency Genotype by Relling, M V, McDonagh, E M, Chang, T, Caudle, K E, McLeod, H L, Haidar, C E, Klein, T, Luzzatto, L

“…Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is associated with development of acute hemolytic anemia (AHA) induced by a number of drugs. We provide…”
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Malaria. Protecting against bad air by Luzzatto, L, Notaro, R

“…It was J.B. S. Haldane who first pointed out that an infectious disease causing high mortality among children could be important in shaping human evolution by…”
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Targeted disruption of the housekeeping gene encoding glucose 6‐phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress by Pandolfi, P. P., Sonati, F., Rivi, R., Mason, P., Grosveld, F., Luzzatto, L.

“…Glucose 6‐phosphate dehydrogenase (G6PD) is a housekeeping enzyme encoded in mammals by an X‐linked gene. It has important functions in intermediary metabolism…”
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The cellular pathogenesis of paroxysmal nocturnal haemoglobinuria by KARADIMITRIS, A, LUZZATTO, L

“…Paroxysmal nocturnal haemoglobinuria (PNH) is a unique disorder characterised by the triad of intravascular haemolysis, thrombosis and bone marrow failure. In…”
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The mechanisms of neoplastic transformation by Luzzatto, L

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Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG‐A gene by Bessler, M., Mason, P.J., Hillmen, P., Miyata, T., Yamada, N., Takeda, J., Luzzatto, L., Kinoshita, T.

“…Paroxysmal nocturnal haemoglobinuria (PNH), an acquired clonal blood disorder, is caused by the absence of glycosyl phosphatidylinositol (GPI)‐anchored surface…”
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Persistence of expression of the TMPRSS2:ERG fusion gene after pre-surgery androgen ablation may be associated with early prostate specific antigen relapse of prostate cancer: Preliminary results by Bonaccorsi, L., Nesi, G., Nuti, F., Paglierani, M., Krausz, C., Masieri, L., Serni, S., Proietti-Pannunzi, L., Fang, Y., Jhanwar, S. C., Orlando, C., Carini, M., Forti, G., Baldi, E., Luzzatto, L.

“…Background : The recently identified TM-PRSS2:ERG fusion gene is a candidate oncogene for prostate cancer (PCa). Subjects and methods : We have tested for the…”
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Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria by Karadimitris, Anastasios, Manavalan, John S., Thaler, Howard T., Notaro, Rosario, Araten, David J., Nafa, Khedoudja, Roberts, Irene A.G., Weksler, Marc E., Luzzatto, Lucio

“…Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of the hematopoietic stem cell (HSC). Somatic mutations in thePIG-Agene result in the…”
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The spectrum of molecular lesions in human tumors by Luzzatto, L

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Somatic mutations and cellular selection in paroxysmal nocturnal haemoglobinuria by Bessler, M, Mason, P, Hillmen, P, Luzzatto, L

“…Patients with paroxysmal nocturnal haemoglobinuria (PNH) have in their blood two red-cell populations, one normal and one deficient in proteins anchored to the…”
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Prospective analysis of minimal bone marrow infiltration in pediatric Burkitt's lymphomas by long-distance polymerase chain reaction for t(8;14)(q24;q32) by MUSSOLIN, L, BASSO, K, PILLON, M, D'AMORE, E. S, LOMBARDI, A, LUZZATTO, L, ZANESCO, L, ROSOLEN, A

“…The chromosomal translocation t(8;14)(q24;q32) represents a characteristic marker for Burkitt's lymphoma (BL). This translocation involves the MYC oncogene on…”
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18 Paroxysmal nocturnal hemoglobinuria by Luzzatto, L, Notaro, R, Gianfaldoni, G

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Dynamics of hematopoiesis in paroxysmal nocturnal hemoglobinuria (PNH): no evidence for intrinsic growth advantage of PNH clones by ARATEN, D. J, BESSLER, M, MCKENZIE, S, CASTRO-MALASPINA, H, CHILDS, B. H, BOULAD, F, KARADIMITRIS, A, NOTARO, R, LUZZATTO, L

“…PNH is characterized by expansion of one or more stem cell clones with a PIG-A mutation, which causes a severe deficiency in the expression of…”
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Introduction: from the genetic basis of blood disorders to gene transfer for the purpose of gene therapy by Luzzatto, L

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Hemolytic anemia by Beutler, E, Luzzatto, L

“…We entered the 20th century with only meager understanding of the erythrocyte. We leave this century with a relatively detailed understanding of the metabolism…”
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Comprehensive Cancer Care Networks: A realistic model for optimising outcomes and minimising inequalities by Luzzatto, L, Loupakis, F

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The molecular basis of glucose-6-phosphate dehydrogenase deficiency by Vulliamy, T, Mason, P, Luzzatto, L

“…With more than 300 different variants reported, the human enzyme glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) is one of the most polymorphic proteins…”
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Hematologically Important Mutations: Glucose-6-Phosphate Dehydrogenase by Vulliamy, Tom, Luzzatto, Lucio, Hirono, Akira, Beutler, Ernest

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Genetics of red cells and susceptibility to malaria by Luzzatto, L

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