Search Results - "Luzina, Olga A"

Usnic acid and its derivatives for pharmaceutical use: a patent review (2000-2017) by Luzina, Olga A, Salakhutdinov, Nariman F

“…Usnic acid (UA) is a lichen-derived secondary metabolite with a unique dibenzofuran skeleton and is commonly found in lichenized fungi of the genera Usnea and…”
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Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 by Zakharenko, Alexandra L, Luzina, Olga A, Chepanova, Arina A, Dyrkheeva, Nadezhda S, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important repair enzyme that removes various covalent adducts from the 3' end of DNA. Particularly, covalent…”
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Carbonylation of Polyfluorinated 1-Arylalkan-1-ols and Diols in Superacids by Wang, Siqi, Zonov, Yaroslav V, Karpov, Victor M, Luzina, Olga A, Mezhenkova, Tatyana V

“…We describe the carbonylation of a series of mono and dihydroxy derivatives of polyfluorinated alkylbenzenes and benzocycloalkenes with OH groups at benzylic…”
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Triterpenic Acid Amides as Potential Inhibitors of the SARS-CoV-2 Main Protease by Baev, Dmitry S, Blokhin, Mikhail E, Chirkova, Varvara Yu, Belenkaya, Svetlana V, Luzina, Olga A, Yarovaya, Olga I, Salakhutdinov, Nariman F, Shcherbakov, Dmitry N

“…Although the incidence and mortality of SARS-CoV-2 infection has been declining during the pandemic, the problem related to designing novel antiviral drugs…”
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New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors by Filimonov, Aleksander S, Chepanova, Arina A, Luzina, Olga A, Zakharenko, Alexandra L, Zakharova, Olga D, Ilina, Ekaterina S, Dyrkheeva, Nadezhda S, Kuprushkin, Maxim S, Kolotaev, Anton V, Khachatryan, Derenik S, Patel, Jinal, Leung, Ivanhoe K H, Chand, Raina, Ayine-Tora, Daniel M, Reynisson, Johannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can…”
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Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors-New Usnic Acid Derivatives by Kornienko, Tatyana E, Chepanova, Arina A, Zakharenko, Alexandra L, Filimonov, Aleksandr S, Luzina, Olga A, Dyrkheeva, Nadezhda S, Nikolin, Valeriy P, Popova, Nelly A, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme and one of the causes of tumor resistance to topoisomerase 1 inhibitors such as…”
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Synthesis and Evaluation of Hypoglycemic Activity of Structural Isomers of ((Benzyloxy)phenyl)propanoic Acid Bearing an Aminobornyl Moiety by Kuranov, Sergey O, Pon Kina, Darya A, Meshkova, Yulia V, Marenina, Mariya K, Khvostov, Mikhail V, Luzina, Olga A, Tolstikova, Tatiana G, Salakhutdinov, Nariman F

“…Free fatty acid receptor-1 (FFAR1) agonists are promising candidates for therapy of type 2 diabetes because of their ability to normalize blood sugar levels…”
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Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties by Ivankin, Dmitry I, Kornienko, Tatyana E, Mikhailova, Marina A, Dyrkheeva, Nadezhda S, Zakharenko, Alexandra L, Achara, Chigozie, Reynisson, Jóhannes, Golyshev, Victor M, Luzina, Olga A, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy; the use of TDP1 inhibitors with a topoisomerase 1 poison such as topotecan…”
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Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors by Gladkova, Elizaveta D, Chepanova, Arina A, Ilina, Ekaterina S, Zakharenko, Alexandra L, Reynisson, Jóhannes, Luzina, Olga A, Volcho, Konstantin P, Lavrik, Olga I, Salakhutdinov, Nariman F

“…A new type of berberine derivatives was obtained by the reaction of berberrubine with aliphatic sulfonyl chlorides. The new polycyclic compounds have a sultone…”
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New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1 by Dyrkheeva, Nadezhda S, Filimonov, Aleksandr S, Luzina, Olga A, Orlova, Kristina A, Chernyshova, Irina A, Kornienko, Tatyana E, Malakhova, Anastasia A, Medvedev, Sergey P, Zakharenko, Alexandra L, Ilina, Ekaterina S, Anarbaev, Rashid O, Naumenko, Konstantin N, Klabenkova, Kristina V, Burakova, Ekaterina A, Stetsenko, Dmitry A, Zakian, Suren M, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Tyrosyl-DNA phosphodiesterase 1 (TDP1) catalyzes the cleavage of the phosphodiester bond between the tyrosine residue of topoisomerase 1 (TOP1) and the 3'…”
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(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses by Filimonov, Aleksandr S, Yarovaya, Olga I, Zaykovskaya, Anna V, Rudometova, Nadezda B, Shcherbakov, Dmitriy N, Chirkova, Varvara Yu, Baev, Dmitry S, Borisevich, Sophia S, Luzina, Olga A, Pyankov, Oleg V, Maksyutov, Rinat A, Salakhutdinov, Nariman F

“…In order to test the antiviral activity, a series of usnic acid derivatives were synthesized, including new, previously undescribed compounds. The activity of…”
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Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives by Khvostov, Mikhail V, Gladkova, Elizaveta D, Borisov, Sergey A, Fedotova, Marina S, Zhukova, Nataliya A, Marenina, Mariya K, Meshkova, Yuliya V, Luzina, Olga A, Tolstikova, Tatiana G, Salakhutdinov, Nariman F

“…Novel 9-N-alkyltetrahydroberberine derivatives were synthesized, among which, based on the results of OGTT, one compound containing the longest aliphatic…”
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Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor by Dyrkheeva, Nadezhda S, Malakhova, Anastasia A, Zakharenko, Aleksandra L, Okorokova, Larisa S, Shtokalo, Dmitriy N, Pavlova, Sophia V, Medvedev, Sergey P, Zakian, Suren M, Nushtaeva, Anna A, Tupikin, Alexey E, Kabilov, Marsel R, Khodyreva, Svetlana N, Luzina, Olga A, Salakhutdinov, Nariman F, Lavrik, Olga I

“…Topoisomerase 1 (TOP1) is an enzyme that regulates DNA topology and is essential for replication, recombination, and other processes. The normal TOP1 catalytic…”
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The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme by Gladkova, Elizaveta D, Nechepurenko, Ivan V, Bredikhin, Roman A, Chepanova, Arina A, Zakharenko, Alexandra L, Luzina, Olga A, Ilina, Ekaterina S, Dyrkheeva, Nadezhda S, Mamontova, Evgeniya M, Anarbaev, Rashid O, Reynisson, Jóhannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

“…A series of berberine and tetrahydroberberine sulfonate derivatives were prepared and tested against the tyrosyl-DNA phosphodiesterase 1 (Tdp1) DNA-repair…”
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Terpene-Containing Analogues of Glitazars as Potential Therapeutic Agents for Metabolic Syndrome by Blokhin, Mikhail E, Kuranov, Sergey O, Khvostov, Mikhail V, Fomenko, Vladislav V, Luzina, Olga A, Zhukova, Natalia A, Elhajjar, Cham, Tolstikova, Tatiana G, Salakhutdinov, Nariman F

“…Metabolic syndrome is a complex of abnormalities involving impaired glucose and lipid metabolism, which needs effective pharmacotherapy. One way to reduce…”
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The Potential of Usnic-Acid-Based Thiazolo-Thiophenes as Inhibitors of the Main Protease of SARS-CoV-2 Viruses by Yarovaya, Olga I, Filimonov, Aleksandr S, Baev, Dmitriy S, Borisevich, Sophia S, Zaykovskaya, Anna V, Chirkova, Varvara Yu, Marenina, Mariya K, Meshkova, Yulia V, Belenkaya, Svetlana V, Shcherbakov, Dmitriy N, Gureev, Maxim A, Luzina, Olga A, Pyankov, Oleg V, Salakhutdinov, Nariman F, Khvostov, Mikhail V

“…Although the COVID-19 pandemic caused by SARS-CoV-2 viruses is officially over, the search for new effective agents with activity against a wide range of…”
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Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus by Shtro, Anna A., Gladkova, Elizaveta D., Galochkina, Anastasia V., Nikolaeva, Yulia V., Garshinina, Angelika V., Razgulyaeva, Darya N., Sorokin, Evgeniy V., Tsareva, Tatyana R., Luzina, Olga A., Salakhutdinov, Nariman F.

“…A series of derivatives of berberine was synthesized to estimate their antiviral activity toward respiratory syncytial virus. Berberine and its hydrogenated…”
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New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition by Dyrkheeva, Nadezhda S., Filimonov, Aleksandr S., Luzina, Olga A., Zakharenko, Alexandra L., Ilina, Ekaterina S., Malakhova, Anastasia A., Medvedev, Sergey P., Reynisson, Jóhannes, Volcho, Konstantin P., Zakian, Suren M., Salakhutdinov, Nariman F., Lavrik, Olga I.

“…Usnic acid (UA) is a secondary metabolite of lichens that exhibits a wide range of biological activities. Previously, we found that UA derivatives are…”
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Discovery of the First in Class 9-N-Berberine Derivative as Hypoglycemic Agent with Extra-Strong Action by Khvostov, Mikhail V, Gladkova, Elizaveta D, Borisov, Sergey A, Zhukova, Nataliya A, Marenina, Mariya K, Meshkova, Yuliya V, Luzina, Olga A, Tolstikova, Tatijana G, Salakhutdinov, Nariman F

“…Berberine is well known for its ability to reduce the blood glucose level, but its high effective dose and poor bioavailability limits its use. In this work we…”
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(1R,2R,4R)-N-((4-((4-(2-Carboxyethyl)phenoxy)methyl)thiophen-2-yl)methyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-aminium Chloride by Kuranov, Sergey O., Marenina, Mariya K., Khvostov, Mikhail V., Luzina, Olga A., Tolstikova, Tatiana G., Salakhutdinov, Nariman F.

“…A novel free fatty acid receptor 1 (FFAR1) agonist has been synthesized and evaluated in vitro. The synthesis of the title compound was performed from…”
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