Search Results - "Luxenburg, Chen"

From cell shape to cell fate via the cytoskeleton — Insights from the epidermis by Luxenburg, Chen, Zaidel-Bar, Ronen

“…Animal cells exhibit a wide range of shapes that reflect their diverse functions. Cell shape is determined by a balance between internal and external forces…”
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SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium by Bhattacharya, Swarnabh, Serror, Laura, Nir, Eshkar, Dhiraj, Dalbir, Altshuler, Anna, Khreish, Maroun, Tiosano, Beatrice, Hasson, Peleg, Panman, Lia, Luxenburg, Chen, Aberdam, Daniel, Shalom‐Feuerstein, Ruby

“…Mutations in key transcription factors SOX2 and P63 were linked with developmental defects and postnatal abnormalities such as corneal opacification,…”
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Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy by Gutwillig, Amit, Santana-Magal, Nadine, Farhat-Younis, Leen, Rasoulouniriana, Diana, Madi, Asaf, Luxenburg, Chen, Cohen, Jonathan, Padmanabhan, Krishnanand, Shomron, Noam, Shapira, Guy, Gleiberman, Annette, Parikh, Roma, Levy, Carmit, Feinmesser, Meora, Hershkovitz, Dov, Zemser-Werner, Valentina, Zlotnik, Oran, Kroon, Sanne, Hardt, Wolf-Dietrich, Debets, Reno, Reticker-Flynn, Nathan Edward, Rider, Peleg, Carmi, Yaron

“…Despite the remarkable successes of cancer immunotherapies, the majority of patients will experience only partial response followed by relapse of resistant…”
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Apoptosis and tissue thinning contribute to symmetric cell division in the developing mouse epidermis in a nonautonomous way by Soffer, Arad, Mahly, Adnan, Padmanabhan, Krishnanand, Cohen, Jonathan, Adir, Orit, Loushi, Eidan, Fuchs, Yaron, Williams, Scott E, Luxenburg, Chen

“…Mitotic spindle orientation (SO) is a conserved mechanism that governs cell fate and tissue morphogenesis. In the developing epidermis, a balance between…”
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Involvement of actin polymerization in podosome dynamics by Luxenburg, Chen, Winograd-Katz, Sabina, Addadi, Lia, Geiger, Benjamin

“…Podosomes, which are formed by different monocyte derivatives, are small adhesion structures whose coordinated dynamics and cytoskeletal reorganization drive…”
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The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly by Luxenburg, Chen, Geblinger, Dafna, Klein, Eugenia, Anderson, Karen, Hanein, Dorit, Geiger, Benny, Addadi, Lia

“…Osteoclasts are bone-degrading cells, which play a central role in physiological bone remodeling. Unbalanced osteoclast activity is largely responsible for…”
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Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity by Luxenburg, Chen, Heller, Evan, Pasolli, H. Amalia, Chai, Sophia, Nikolova, Maria, Stokes, Nicole, Fuchs, Elaine

“…During mouse development, core planar cell polarity (PCP) proteins become polarized in the epidermal plane to guide angling/morphogenesis of hair follicles…”
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Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis by Doron, Hila, Amer, Malak, Ershaid, Nour, Blazquez, Raquel, Shani, Ophir, Lahav, Tzlil Gener, Cohen, Noam, Adler, Omer, Hakim, Zahi, Pozzi, Sabina, Scomparin, Anna, Cohen, Jonathan, Yassin, Muhammad, Monteran, Lea, Grossman, Rachel, Tsarfaty, Galia, Luxenburg, Chen, Satchi-Fainaro, Ronit, Pukrop, Tobias, Erez, Neta

“…Melanoma is the deadliest skin cancer due to its high rate of metastasis, frequently to the brain. Brain metastases are incurable; therefore, understanding…”
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Anillin governs mitotic rounding during early epidermal development by Mahly, Adnan, Padmanabhan, Krishnanand, Soffer, Arad, Cohen, Jonathan, Omar, Jana, Sagi-Eisenberg, Ronit, Luxenburg, Chen

“…Abstract Background The establishment of tissue architecture requires coordination between distinct processes including basement membrane assembly, cell…”
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Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation by Azazmeh, Narmen, Assouline, Benjamin, Winter, Eitan, Ruppo, Shmuel, Nevo, Yuval, Maly, Alexander, Meir, Karen, Witkiewicz, Agnieszka K., Cohen, Jonathan, Rizou, Sophia V., Pikarsky, Eli, Luxenburg, Chen, Gorgoulis, Vassilis G., Ben-Porath, Ittai

“…p16 INK4a (CDKN2A) is a central tumor suppressor, which induces cell-cycle arrest and senescence. Cells expressing p16 INK4a accumulate in aging tissues and…”
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Mutations in TSPEAR, Encoding a Regulator of Notch Signaling, Affect Tooth and Hair Follicle Morphogenesis by Peled, Alon, Sarig, Ofer, Samuelov, Liat, Bertolini, Marta, Ziv, Limor, Weissglas-Volkov, Daphna, Eskin-Schwartz, Marina, Adase, Christopher A, Malchin, Natalia, Bochner, Ron, Fainberg, Gilad, Goldberg, Ilan, Sugawara, Koji, Baniel, Avital, Tsuruta, Daisuke, Luxenburg, Chen, Adir, Noam, Duverger, Olivier, Morasso, Maria, Shalev, Stavit, Gallo, Richard L, Shomron, Noam, Paus, Ralf, Sprecher, Eli

“…Despite recent advances in our understanding of the pathogenesis of ectodermal dysplasias (EDs), the molecular basis of many of these disorders remains…”
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Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape by Cohen, Jonathan, Luxenburg, Chen

“…The WASP-family verprolin-homologous (Wave) complex enhances actin-related protein 2/3 (Arp2/3)-mediated actin polymerization. Recently, we have identified a…”
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Numb-associated kinases regulate sandfly-borne Toscana virus entry by Moalem, Yarden, Katz, Rodolfo, Subramaniam, Anand G, Malis, Yehonathan, Yaffe, Yakey, Borenstein-Auerbach, Nofit, Tadmor, Keshet, Raved, Roey, Maoz, Ben M, Yoo, Ji Seung, Lustig, Yaniv, Luxenburg, Chen, Perlson, Eran, Einav, Shirit, Sklan, Ella H

“…Sandfly-borne Toscana virus (TOSV) is an enveloped tri-segmented negative single-strand RNA . It is an emerging virus predominantly endemic in southwestern…”
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Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src by Granot-Attas, Shira, Luxenburg, Chen, Finkelshtein, Eynat, Elson, Ari

“…The nonreceptor isoform of tyrosine phosphatase epsilon (cyt-PTPe) supports osteoclast adhesion and activity in vivo, leading to increased bone mass in female…”
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Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts by Luxenburg, Chen, Parsons, J. Thomas, Addadi, Lia, Geiger, Benjamin

“…Osteoclasts are large, multinucleated cells that adhere to bone via podosomes, and degrade it. During osteoclast polarization, podosomes undergo reorganization…”
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The molecular dynamics of osteoclast adhesions by Luxenburg, Chen, Addadi, Lia, Geiger, Benjamin

“…Podosomes are specialized adhesive structures that play a central role in bone resorption. In this article we address the molecular diversity and dynamics of…”
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Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses by Nadar-Ponniah, Prathamesh T, Taiber, Shahar, Caspi, Michal, Koffler-Brill, Tal, Dror, Amiel A, Siman-Tov, Ronen, Rubinstein, Moran, Padmanabhan, Krishnanand, Luxenburg, Chen, Lang, Richard A, Avraham, Karen B, Rosin-Arbesfeld, Rina

“…Striatin, a subunit of the serine/threonine phosphatase PP2A, is a core member of the conserved striatin-interacting phosphatase and kinase (STRIPAK)…”
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The contractome--a systems view of actomyosin contractility in non-muscle cells by Zaidel-Bar, Ronen, Zhenhuan, Guo, Luxenburg, Chen

“…Actomyosin contractility is a highly regulated process that affects many fundamental biological processes in each and every cell in our body. In this Cell…”
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Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity by Padmanabhan, Krishnanand, Grobe, Hanna, Cohen, Jonathan, Soffer, Arad, Mahly, Adnan, Adir, Orit, Zaidel-Bar, Ronen, Luxenburg, Chen

“…Planar cell polarity (PCP) is essential for tissue morphogenesis and homeostasis; however, the mechanisms that orchestrate the cell shape and packing dynamics…”
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The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling by Cohen, Jonathan, Raviv, Shaul, Adir, Orit, Padmanabhan, Krishnanand, Soffer, Arad, Luxenburg, Chen

“…Development of the skin epidermis requires tight spatiotemporal control over the activity of several signaling pathways; however, the mechanisms that…”
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