Search Results - "Luxenberg, Deborah P"

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides by Liang, Spencer C, Tan, Xiang-Yang, Luxenberg, Deborah P, Karim, Riyez, Dunussi-Joannopoulos, Kyriaki, Collins, Mary, Fouser, Lynette A

“…Th17 cells are a distinct lineage of effector CD4(+) T cells characterized by their production of interleukin (IL)-17. We demonstrate that Th17 cells also…”
Get full text

The Human IL-17F/IL-17A Heterodimeric Cytokine Signals through the IL-17RA/IL-17RC Receptor Complex by Wright, Jill F, Bennett, Frann, Li, Bilian, Brooks, Jonathan, Luxenberg, Deborah P, Whitters, Matthew J, Tomkinson, Kathleen N, Fitz, Lori J, Wolfman, Neil M, Collins, Mary, Dunussi-Joannopoulos, Kyri, Chatterjee-Kishore, Moitreyee, Carreno, Beatriz M

“…IL-17A and IL-17F, produced by the Th17 CD4(+) T cell lineage, have been linked to a variety of inflammatory and autoimmune conditions. We recently reported…”
Get full text

Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells by Wright, Jill F., Guo, Yongjing, Quazi, Amira, Luxenberg, Deborah P., Bennett, Frann, Ross, John F., Qiu, Yongchang, Whitters, Matthew J., Tomkinson, Kathleen N., Dunussi-Joannopoulos, Kyri, Carreno, Beatriz M., Collins, Mary, Wolfman, Neil M.

“…IL-17F and IL-17A are members of the IL-17 pro-inflammatory cytokine family. IL-17A has been implicated in the pathogenesis of autoimmune diseases. IL-17F is a…”
Get full text

IL-22R, IL-10R2, and IL-22BP Binding Sites Are Topologically Juxtaposed on Adjacent and Overlapping Surfaces of IL-22 by Wu, Paul W., Li, Jing, Kodangattil, Sreekumar R., Luxenberg, Deborah P., Bennett, Frann, Martino, Margot, Collins, Mary, Dunussi-Joannopoulos, Kyriaki, Gill, Davinder S., Wolfman, Neil M., Fouser, Lynette A.

“…Interleukin (IL) 22 is a type II cytokine that is produced by immune cells and acts on nonimmune cells to regulate local tissue inflammation. As a product of…”
Get full text

Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line by Geoghegan, Kieran F., Song, Xi, Hoth, Lise R., Feng, Xidong, Shanker, Suman, Quazi, Amira, Luxenberg, Deborah P., Wright, Jill F., Griffor, Matthew C.

“…► Human recombinant interleukin-17A expressed in HEK293 cells was variably glycosylated. ► Mass spectrometry was used to characterize its glycosylation. ► At…”
Get full text

A simple high-throughput purification method for hit identification in protein screening by Cummins, Emma, Luxenberg, Deborah P., McAleese, Fionnuala, Widom, Angela, Fennell, Brian J., Darmanin-Sheehan, Alfredo, Whitters, Matthew J., Bloom, Laird, Gill, Davinder, Cunningham, Orla

“…Phage and ribosome display technologies have emerged as important tools in the high-throughput screening of protein pharmaceuticals. However, a challenge…”
Get full text

Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evaluation by Toriumi, D M, Kotler, H S, Luxenberg, D P, Holtrop, M E, Wang, E A

“…Bone morphogenetic protein-2 (BMP-2) is a human recombinant bone-inducing factor that stimulates bone formation within 14 days. Twenty-six dogs underwent…”
Get more information

Recombinant Human Bone Morphogenetic Protein Induces Bone Formation by Wang, Elizabeth A., Rosen, Vicki, D'Alessandro, Josephine S., Bauduy, Marc, Cordes, Paul, Harada, Tomoko, Israel, David I., Hewick, Rodney M., Kerns, Kelvin M., LaPan, Peter, Luxenberg, Deborah H., McQuid, David, Moutsatsos, Ioannis K., Nove, John, Wozney, John M.

“…We have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a…”
Get full text

223 IL-22R, IL-10R2 and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22 by Wu, Paul W., Li, Jing, Kodangattil, Sreekumar R., Luxenberg, Deborah P., Bennett, Frann, Martino, Margot, Collins, Mary, Dunussi-Joannopoulos, Kyriaki, Gill, Davinder S., Wolfman, Neil M., Fouser, Lynette A.

Get full text

The functional activity of human IL-17A, IL-17F and IL-17A/IL-17F cytokines is dependent on the receptors IL-17R and IL-17RC (94.31) by Wright, Jill F, Bennett, Frann, Li, Bilian, Brooks, Jonathan, Luxenberg, Deborah P, Whitters, Matthew J, Tomkinson, Kathleen N, Fitz, Lori J, Wolfman, Neil M, Collins, Mary, Carreno, Beatriz M, Dunussi-Joannopoulos, Kyri, Chatterjee-Kishore, Moitreyee

“…Abstract IL-17A and IL-17F are members of the IL-17 cytokine family and have been detected in tissue samples from patients with autoimmune disease. Recent data…”
Get full text

Purification and Characterization of Other Distinct Bone-Inducing Factors by Wang, Elizabeth A., Rosen, Vicki, Cordes, Paul, Hewick, Rodney M., Kriz, Mary Jo, Luxenberg, Deborah P., Sibley, Barbara S., Wozney, John M.

“…We purified a factor that induces bone formation >300,000-fold from guanidinium chloride extracts of demineralized bone. Fifty nanograms of highly purified…”
Get full text

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins by Wong, Gordon G., Witek, JoAnn S., Temple, Patricia A., Wilkens, Kathleen M., Leary, Anne C., Luxenberg, Deborah P., Jones, Simon S., Brown, Eugene L., Kay, Robert M., Orr, Elizabeth C., Shoemaker, Charles, Golde, David W., Kaufman, Randal J., Hewick, Rodney M., Wang, Elizabeth A., Clark, Steven C.

“…Clones of complementary DNA encoding the human lymphokine known as granulocyte-macrophage colony-stimulating factor (GM-CSF) were isolated by means of a…”
Get full text