Search Results - "Lux, MP"
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A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
Published in Nature genetics (01-07-2018)“…The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes…”
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Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis
Published in International journal of epidemiology (01-06-2019)“…Abstract Background In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin…”
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3
Genome-wide association analysis identifies three new breast cancer susceptibility loci
Published in Nature genetics (01-03-2012)“…Douglas Easton and colleagues report a genome-wide association analyses for breast cancer in ~70,000 cases and ~68,000 controls. They identify three new breast…”
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4
Genome-wide association study of germline variants and breast cancer-specific mortality
Published in British journal of cancer (2019)“…Background We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry…”
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Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer
Published in Carcinogenesis (New York) (01-05-2014)“…Summary In a genome-wide scan, we show that 30 variants in 25 genomic regions are associated with risk of TN breast cancer. Women carrying many of the risk…”
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MELODY (Methods for Localization of Different Types of Breast Lesions): A prospective non-interventional multicenter cohort study to evaluate different imaging-guided methods for localization of malignant breast lesions (EUBREAST-4/iBRA-NET)
Published in JOURNAL OF CLINICAL ONCOLOGY (01-06-2023)“…TPS626 Background: In the last decades, the proportion of breast cancer patients receiving breast-conserving surgery has increased, reaching 70-80% in…”
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Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)
Published in Cancers (12-02-2023)“…Surgical excision of a non-palpable breast lesion requires a localization step. Among available techniques, wire-guided localization (WGL) is most commonly…”
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Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1
Published in American journal of human genetics (05-12-2013)“…The 10q26 locus in the second intron of FGFR2 is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association…”
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The Impasse on Overall Survival in Oncology Reimbursement Decision-Making: How Can We Resolve This?
Published in Cancer management and research (01-01-2021)“…Mature overall survival (OS) data are often unavailable at the time of regulatory and reimbursement decisions for a new cancer treatment. For patients with…”
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Abstract P2-09-04: Identification of a neoantigen targeted by tumor-infiltrating lymphocytes in a patient with Her2+ breast cancer
Published in Cancer research (Chicago, Ill.) (15-02-2019)“…Abstract Background: Recent studies have demonstrated that the number of tumor infiltrating lymphocytes (TILs) positively correlates with outcome and response…”
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Hereditary breast and ovarian cancer : review and future perspectives
Published in Journal of molecular medicine (Berlin, Germany) (2006)“…Breast cancer (BC) is the most frequent carcinoma in women. The cumulative risk for the disease is 10% up to the age of 80 years. A familial history of BC and…”
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Abstract OT1-11-02: PRAEGNANT - Real world evidence, translational research, big and smart data: A prospective academic translational research network for the optimization of the oncological health care quality in the adjuvant and advanced/ metastatic setting (NCT02338167)
Published in Cancer research (Chicago, Ill.) (15-02-2019)“…Abstract Background During the last decades the treatment of advanced breast cancer (ABC) patients has improved due to a variety of new treatment strategies…”
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Abstract P6-17-22: Progression free survival (PFS) and overall survival (OS) of patients treated with trastuzumab emtansine (T-DM1) after previous treatment with pertuzumab in patients with advanced breast cancer (NCT02338167)
Published in Cancer research (Chicago, Ill.) (15-02-2019)“…Abstract Background Studies leading to the approval of trastuzumab emtansine (T-DM1) have been conducted without pertuzumab as previous therapy. Therefore data…”
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Abstract P6-17-37: Therapy landscape of patients with metastatic, HER2 positive breast cancer - Data from the real world breast cancer registry PRAEGNANT (NCT02338167)
Published in Cancer research (Chicago, Ill.) (15-02-2019)“…Abstract Purpose: This analysis describes comprehensive real-world data concerning the use of anti-HER2 therapies in HER2 positive metastatic breast cancer…”
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Abstract P6-11-10: Impact of disease progression on health-related quality of life in patients with metastatic breast cancer in the PRAEGNANT breast cancer registry
Published in Cancer research (Chicago, Ill.) (15-02-2018)“…Abstract Background: Improved progression-free survival is considered as treatment goal for patients with metastatic breast cancer (MBC) since it is assumed to…”
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Abstract P1-07-20: Developing prognostic indicators of poor outcomes in PRAEGNANT metastatic breast cancer cohort
Published in Cancer research (Chicago, Ill.) (15-02-2018)“…Abstract Background: Despite novel, targeted therapies, metastatic breast cancer patients have an extremely unfavourable prognosis. Prognostic and predictive…”
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Abstract PD1-02: Cancer predisposition genes in metastatic breast cancer – Association with metastatic pattern, prognosis, patient and tumor characteristics
Published in Cancer research (Chicago, Ill.) (15-02-2018)“…Abstract Background New treatment strategies for metastatic breast cancer (mBC) are mainly driven by therapies against specific targets. BRCA mutations are one…”
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Abstract P3-11-07: Factors associated with first line chemotherapy use in patients with hormone receptor positive, HER2 negative metastatic breast cancer – data from the PRAEGNANT breast cancer registry
Published in Cancer research (Chicago, Ill.) (15-02-2018)“…Abstract Background For breast cancer patients with metastases which are not life threatening national and international guidelines recommend the exhaustion of…”
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Abstract P5-21-09: Overall survival of metastatic breast cancer patients – data from the PRAEGNANT breast cancer registry
Published in Cancer research (Chicago, Ill.) (15-02-2018)“…Abstract Background Breast Cancer registries can help to understand how patient groups are treated outside clinical trials and what outcome is to expected for…”
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Abstract OT3-02-09: Seraphina – Safety efficacy and patient reported outcomes of advanced breast cancer patients: Therapy management with NAB-paclitaxel in daily routine
Published in Cancer research (Chicago, Ill.) (15-02-2016)“…Abstract BACKGROUND Treatment of patients with advanced breast cancer (ABC) has evolved significantly. Nevertheless, further improvement in ABC treatment is a…”
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