Search Results - "Lux, Elizabeth"

Acetyltransferase p300 inhibitor reverses hypertension‐induced cardiac fibrosis by Rai, Rahul, Sun, Tianjiao, Ramirez, Veronica, Lux, Elizabeth, Eren, Mesut, Vaughan, Douglas E., Ghosh, Asish K.

“…Epigenetic dysregulation plays a crucial role in cardiovascular diseases. Previously, we reported that acetyltransferase p300 (ATp300) inhibitor L002 prevents…”
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Role of PAI-1 in hepatic steatosis and dyslipidemia by Levine, Joshua A., Oleaga, Carlota, Eren, Mesut, Amaral, Ansel P., Shang, Meng, Lux, Elizabeth, Khan, Sadiya S., Shah, Sanjiv J., Omura, Yasuhiro, Pamir, Nathalie, Hay, Joshua, Barish, Grant, Miyata, Toshio, Tavori, Hagai, Fazio, Sergio, Vaughan, Douglas E.

“…Plasminogen activator inhibitor 1 (PAI-1) is a functional biomarker of the metabolic syndrome. Previous studies have demonstrated that PAI-1 is a mechanistic…”
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A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis by Rai, Rahul, Verma, Suresh K., Kim, David, Ramirez, Veronica, Lux, Elizabeth, Li, Chengjin, Sahoo, Susmita, Wilsbacher, Lisa D., Vaughan, Douglas E., Quaggin, Susan E., Ghosh, Asish K.

“…Hypertension-associated end-organ damage commonly leads to cardiac and renal fibrosis. As no effective anti-fibrotic therapy currently exists, the unchecked…”
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Echinoderm Phosphorylated Matrix Proteins UTMP16 and UTMP19 Have Different Functions in Sea Urchin Tooth Mineralization by Alvares, Keith, Dixit, Saryu N., Lux, Elizabeth, Veis, Arthur

“…Studies of mineralization of embryonic spicules and of the sea urchin genome have identified several putative mineralization-related proteins. These predicted…”
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Abstract 14009: Plasminogen Activator Inhibitor-1 (PAI-1) is an Essential Driver of Cardiovascular Aging in Mice by Kalousdian, Anthony, Soberanes, Saul, Eren, Mesut, Jorgensen, Emily, Lux, Elizabeth, Wilsbacher, Lisa D, Vaughan, Douglas E

“…Abstract only Introduction: PAI-1 is the protein product of the gene Serpine1 . PAI-1 is a key contributor to cellular senescence in humans and mice, and…”
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TCT-843 Association of Dual Antiplatelet Therapy and PAI-1 in Coronary Artery Disease by Davidson, Laura, Khan, Sadiya, Lux, Elizabeth, Flevaris, Panagiotis, Vaughan, Douglas

“…Despite the prevalent use of antiplatelet therapy in patients with coronary artery disease (CAD), the effect of antiplatelet therapy on PAI-1 levels has not…”
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Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5 by Ghosh, Asish K., Soberanes, Saul, Lux, Elizabeth, Shang, Meng, Aillon, Raul Piseaux, Eren, Mesut, Budinger, G.R. Scott, Miyata, Toshio, Vaughan, Douglas E.

“…Numerous studies have established that acute or chronic exposure to environmental pollutants like particulate matter (PM) leads to the development of…”
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Cardiomyocyte PAI-1 influences the cardiac transcriptome and limits the extent of cardiac fibrosis in response to left ventricular pressure overload by Ghosh, Asish K., Kalousdian, Anthony A., Shang, Meng, Lux, Elizabeth, Eren, Mesut, Keating, Anna, Wilsbacher, Lisa D., Vaughan, Douglas E.

“…Plasminogen activator inhibitor-1 (PAI-1) is a specific and rapid-acting inhibitor of endogenous plasminogen activators (uPA and tPA). The global PAI-1…”
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Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM 2.5 by Ghosh, Asish K, Soberanes, Saul, Lux, Elizabeth, Shang, Meng, Aillon, Raul Piseaux, Eren, Mesut, Budinger, G R Scott, Miyata, Toshio, Vaughan, Douglas E

“…Numerous studies have established that acute or chronic exposure to environmental pollutants like particulate matter (PM) leads to the development of…”
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OR22-6 Reversal Of Diet Induced Metabolic Syndrome In Mice With An Orally Active Small Molecule Inhibitor Of PAI-1 by Levine, Joshua, Sun, Tianjiao, Eren, Mesut, Lux, Elizabeth, Miyata, Toshiyo, Barish, Grant, Douglas, Vaughan

“…Plasminogen activator inhibitor 1 (PAI-1) is a member of the serpin family of proteases that inhibits tissue-type plasminogen activator and urokinase. Elevated…”
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Assessment of Virological Contributions to COVID-19 Outcomes in a Longitudinal Cohort of Hospitalized Adults by Simons, Lacy M, Lorenzo-Redondo, Ramon, Gibson, Meg, Kinch, Sarah L, Vandervaart, Jacob P, Reiser, Nina L, Eren, Mesut, Lux, Elizabeth, McNally, Elizabeth M, Tambur, Anat R, Vaughan, Douglas E, Bachta, Kelly E R, Demonbreun, Alexis R, Satchell, Karla J F, Achenbach, Chad J, Ozer, Egon A, Ison, Michael G, Hultquist, Judd F

“…Abstract Background While several demographic and clinical correlates of coronavirus disease 2019 (COVID-19) outcome have been identified, their relationship…”
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On the formation and functions of high and very high magnesium calcites in the continuously growing teeth of the echinoderm Lytechinus variegatus: development of crystallinity and protein involvement by Veis, Arthur, Stock, Stuart R, Alvares, Keith, Lux, Elizabeth

“…Sea urchin teeth grow continuously and develop a complex mineralized structure consisting of spatially separate but crystallographically aligned first stage…”
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P16 and P19; mineralization-related Echinoderm phosphoproteins by Alvares, Keith, Dixit, Saryu, Lux, Elizabeth, Veis, Arthur

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The proteome of the developing tooth of the sea urchin, Lytechinus variegatus: mortalin is a constituent of the developing cell syncytium by Alvares, Keith, Dixit, Saryu N., Lux, Elizabeth, Barss, Joseph, Veis, Arthur

“…Echinoderm teeth are continuously growing calcite‐mineralized tissues of complex structure. Two features are of special interest: (1) cell division takes place…”
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A clinical study of the pharmacology of an inhaled nicotine aerosol by Lux, Jo Ann Elizabeth

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