Search Results - "Luuk M. van Langen"

Transaminase‐Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions by Ruggieri, Federica, van Langen, Luuk M., Logan, Derek T., Walse, Björn, Berglund, Per

“…Dynamic kinetic resolution (DKR) reactions in which a stereoselective enzyme and a racemization step are coupled in one pot would represent powerful tools for…”
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Biosynthesis of Furfurylamines in Batch and Continuous Flow by Immobilized Amine Transaminases by Tobias Heinks, Luisa M. Merz, Jan Liedtke, Matthias Höhne, Luuk M. van Langen, Uwe T. Bornscheuer, Gabriele Fischer von Mollard, Per Berglund

“…Building blocks with amine functionality are crucial in the chemical industry. Biocatalytic syntheses and chemicals derived from renewable resources are…”
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A new, mild cross-linking methodology to prepare cross-linked enzyme aggregates by Mateo, Cesar, Palomo, José M., van Langen, Luuk M., van Rantwijk, Fred, Sheldon, Roger A.

“…Cross‐linked enzyme aggregates (CLEAs) were prepared from several enzymes (penicillin G acylase, hydroxynitrile lyase, alcohol dehydrogenase, and two different…”
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Multi-Catalytic Route for the Synthesis of (S)-Tembamide by Laura Leemans, Marc D. Walter, Frank Hollmann, Anett Schallmey, Luuk M. van Langen

“…Enantiopure β-amino alcohols constitute one of the most significant building blocks for the synthesis of active pharmaceutical ingredients. Despite the…”
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Cross-Linked Aggregates of the Hydroxynitrile Lyase from Manihot esculenta: Highly Active and Robust Biocatalysts by Chmura, Andrzej, van der Kraan, Geert M., Kielar, Filip, van Langen, Luuk M., van Rantwijk, Fred, Sheldon, Roger A.

“…The precipitation and cross‐linking into CLEAs of the hydroxynitrile lyase (E.C. 4.1.2.10) from Manihot esculenta was investigated and an optimized procedure,…”
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The Role of Buffer, Pyridoxal 5’‐Phosphate and Light on the Stability of the Silicibacter Pomeroyi Transaminase by Merz, Luisa M., Langen, Luuk M., Berglund, Per

“…Transaminases are pyridoxal 5’‐phosphate (PLP)‐dependent enzymes that transfer amino‐functions. The transaminase from Silicibacter pomeroyi (SpATA) exhibits a…”
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Enzymatic Hydrocyanation of a Sterically Hindered Aldehyde. Optimization of a Chemoenzymatic Procedure for (R)-2-Chloromandelic Acid by van Langen, Luuk M, van Rantwijk, Fred, Sheldon, Roger A

“…The asymmetric synthesis of (R)-o-chloromandelic acid, a key intermediate for the anti-thrombotic agent clopidogrel, via the almond meal catalyzed…”
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Evaluation of the performance of immobilized penicillin G acylase using active-site titration by Janssen, Michiel H. A., van Langen, Luuk M., Pereira, Silvia R. M., Rantwijk, Fred van, Sheldon, Roger A.

“…Penicillin G acylase from Escherichia coli was immobilized on Eupergit® C with different enzyme loading. The activity of the immobilized preparations was…”
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A two-step, one-pot enzymatic synthesis of cephalexin from D-phenylglycine nitrile by Wegman, Margreth A., van Langen, Luuk M., van Rantwijk, Fred, Sheldon, Roger A.

“…A cascade of two enzymatic transformations is employed in a one‐pot synthesis of cephalexin. The nitrile hydratase (from R. rhodochrous MAWE)‐catalyzed…”
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Active site titration as a tool for the evaluation of immobilization procedures of penicillin acylase by van Langen, Luuk M., Janssen, Michiel H. A., Oosthoek, Natasja H. P., Pereira, Sílvia R. M., Švedas, Vytas K., van Rantwijk, Fred, Sheldon, Roger A.

“…Native and immobilized preparations of penicillin acylase from Escherichia coli and Alcaligenes faecalis were studied using an active site titration technique…”
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Cross-Linked Aggregates of (R)-Oxynitrilase:  A Stable, Recyclable Biocatalyst for Enantioselective Hydrocyanation by van Langen, Luuk M, Selassa, Rhoderick P, van Rantwijk, Fred, Sheldon, Roger A

“…The (R)-oxynitrilase from almonds was immobilized as a cross-linked enzyme aggregate (CLEA) via precipitation with 1,2-dimethoxyethane and subsequent…”
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Penicillin acylase-catalyzed peptide synthesis: a chemo-enzymatic route to stereoisomers of 3,6-diphenylpiperazine-2,5-dione by van Langen, Luuk M, van Rantwijk, Fred, Švedas, Vytas K, Sheldon, Roger A

“…Chiral dipeptides of phenylglycine were synthesized using immobilized Escherichia coli penicillin acylase. The high selectivity of penicillin acylase for…”
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Highly efficient synthesis of ampicillin in an "aqueous solution-precipitate" system: Repetitive addition of substrates in a semicontinuous process by Youshko, Maxim I., van Langen, Luuk M., de Vroom, Erik, van Rantwijk, Fred, Sheldon, Roger A., Švedas, Vytas K.

“…The synthesis of ampicillin catalyzed by Escherichia coli penicillin acylase was optimized in an aqueous system with partially dissolved antibiotic nucleus…”
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Penicillin acylase-catalyzed ampicillin synthesis using a pH gradient: A new approach to optimization by Youshko, Maxim I., van Langen, Luuk M., de Vroom, Erik, van Rantwijk, Fred, Sheldon, Roger A., Švedas, Vytas K.

“…The penicillin acylase‐catalyzed synthesis of ampicillin by acyl transfer from D‐(–)‐phenylglycine amide (D‐PGA) to 6‐aminopenicillanic acid (6‐APA) becomes…”
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Application of aminoacylase I to the enantioselective resolution of α-amino acid esters and amides by Youshko, Maxim I, van Langen, Luuk M, Sheldon, Roger A, Švedas, Vytas K

“…Graphic Aminoacylase I from Aspergillus melleus, a readily available and inexpensive enzyme mainly used in the industrial production of enantiopure l-amino…”
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Highly efficient and enantioselective enzymatic acylation of amines in aqueous medium by Guranda, Dorel T, van Langen, Luuk M, van Rantwijk, Fred, Sheldon, Roger A, Švedas, Vytas K

“…A new strategy based on the unique catalytic properties, stability and enantioselectivity of the relatively unknown penicillin acylase from Alcaligenes…”
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Penicillin Acylase Catalysed Synthesis of Ampicillin in Hydrophilic Organic Solvents by van Langen, Luuk M., Oosthoek, Natasja H. P., van Rantwijk, Fred, Sheldon, Roger A.

“…Penicillin acylase (EC 3.5.1.11) from Alcaligenes faecalis, immobilised as a cross‐linked enzyme aggregate (CLEA), catalysed the synthesis of ampicillin in…”
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Penicillin acylase-catalyzed peptide synthesis in aqueous medium: a chemo-enzymatic route to stereoisomerically pure diketopiperazines by Khimiuk, Andrei Y., Korennykh, Alexei V., van Langen, Luuk M., van Rantwijk, Fred, Sheldon, Roger A., Švedas, Vytas K.

“…A range of non-natural dipeptides of the general formula d-(−)-phenylglycyl- l-X, where X is a natural α-amino acid, have been prepared by penicillin…”
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Penicillin acylase-catalyzed synthesis of ampicillin in “aqueous solution–precipitate” systems. High substrate concentration and supersaturation effect by Youshko, Maxim I, van Langen, Luuk M, de Vroom, Erik, Moody, Harold M, van Rantwijk, Fred, Sheldon, Roger A, Švedas, Vytas K

“…Penicillin acylase-catalyzed ampicillin synthesis via acyl group transfer in aqueous solution is highly dependent on the initial substrate concentration. The…”
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Cover Feature: The Role of Buffer, Pyridoxal 5’‐Phosphate and Light on the Stability of the Silicibacter Pomeroyi Transaminase (ChemCatChem 2/2023) by Merz, Luisa M., Langen, Luuk M., Berglund, Per

“…The Cover Feature shows Spartan soldiers illustrating the different influences on the stability of the Silicibacter pomeroyi transaminase (SpATA). In their…”
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