Search Results - "Luu, Jennings"

Human aging and disease: Lessons from age-related macular degeneration by Luu, Jennings, Palczewski, Krzysztof

“…Aging is the most significant risk factor associated with chronic disease in humans. The accumulation of genetic damage throughout life leads to a variety of…”
Get full text

Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition by Luu, Jennings C, Saadane, Aicha, Leinonen, Henri, Choi, Elliot H, Gao, Fangyuan, Lewandowski, Dominik, Halabi, Maximilian, Sander, Christopher L, Wu, Arum, Wang, Jacob M, Singh, Rupesh, Gao, Songqi, Lessieur, Emma M, Dong, Zhiqian, Palczewska, Grazyna, Mullins, Robert F, Peachey, Neal S, Kiser, Philip D, Tabaka, Marcin, Kern, Timothy S, Palczewski, Krzysztof

“…Chronic, progressive retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa, arise from genetic and…”
Get full text

Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia by Tworak, Aleksander, Kolesnikov, Alexander V., Hong, John D., Choi, Elliot H., Luu, Jennings C., Palczewska, Grazyna, Dong, Zhiqian, Lewandowski, Dominik, Brooks, Matthew J., Campello, Laura, Swaroop, Anand, Kiser, Philip D., Kefalov, Vladimir J., Palczewski, Krzysztof

“…In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical visual cycle. This shortfall is compensated, in part, by the…”
Get full text

Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision by Lewandowski, Dominik, Foik, Andrzej T, Smidak, Roman, Choi, Elliot H, Zhang, Jianye, Hoang, Thanh, Tworak, Aleksander, Suh, Susie, Leinonen, Henri, Dong, Zhiqian, Pinto, Antonio Fm, Tom, Emily, Luu, Jennings, Lee, Joan, Ma, Xiuli, Bieberich, Erhard, Blackshaw, Seth, Saghatelian, Alan, Lyon, David C, Skowronska-Krawczyk, Dorota, Tabaka, Marcin, Palczewski, Krzysztof

“…Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have…”
Get full text

Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model by Luu, Jennings, Kallestad, Les, Hoang, Thanh, Lewandowski, Dominik, Dong, Zhiqian, Blackshaw, Seth, Palczewski, Krzysztof

“…Abstract Age-related macular degeneration (AMD) is a chronic, multifactorial disorder and a leading cause of blindness in the elderly. Characterized by…”
Get full text

Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice by Kolesnikov, Alexander V., Luu, Jennings, Jin, Hui, Palczewski, Krzysztof, Kefalov, Vladimir J.

“…PurposeLight detection in retinal rod photoreceptors is initiated by activation of the visual pigment rhodopsin. A critical, yet often-overlooked, step…”
Get full text

Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome by Kim, Paul H, Luu, Jennings, Heizer, Patrick, Tu, Yiping, Weston, Thomas A, Chen, Natalie, Lim, Christopher, Li, Robert L, Lin, Po-Yu, Dunn, James C Y, Hodzic, Didier, Young, Stephen G, Fong, Loren G

“…Hutchinson-Gilford progeria syndrome is a disorder of premature aging in children caused by de novo mutations in that lead to the synthesis of an internally…”
Get more information

Structural evidence for visual arrestin priming via complexation of phosphoinositols by Sander, Christopher L., Luu, Jennings, Kim, Kyumhyuk, Furkert, David, Jang, Kiyoung, Reichenwallner, Joerg, Kang, MinSoung, Lee, Ho-Jun, Eger, Bryan T., Choe, Hui-Woog, Fiedler, Dorothea, Ernst, Oliver P., Kim, Yong Ju, Palczewski, Krzysztof, Kiser, Philip D.

“…Visual arrestin (Arr1) terminates rhodopsin signaling by blocking its interaction with transducin. To do this, Arr1 translocates from the inner to the outer…”
Get full text

Stress resilience–enhancing drugs: New class of small molecules holds promise by Luu, Jennings

“…Luu is Harrington Scholar and Medical Scientist Training Program doctoral fellow at the School of Medicine at Case Western Reserve University in Cleveland,…”
Get full text

Stress resilience-enhancing drugs: New class of small molecules holds promise: Therapeutics can prevent vision loss and neurodegeneration in patients by Luu, Jennings, Palczewski, Krzysztof

Get full text