Search Results - "Lutz Frölich"

Alzheimer's disease – the ‘microbial hypothesis’ from a clinical and neuroimaging perspective by Frölich, Lutz

“…•Neurotropic viruses, gut and lung bacteriae, and bovine meat and milk factors may cause AD.•Microbial pathogens may act directly or as a trigger or co-factor…”
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Large Collaborative Registries and Real-world Data to Manage Amyloid-Related Imaging Abnormalities by Piazza, Fabrizio, Frölich, Lutz, Padovani, Alessandro

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Drug development in Alzheimer's disease: the path to 2025 by Cummings, Jeffrey, Aisen, Paul S, DuBois, Bruno, Frölich, Lutz, Jack, Jr, Clifford R, Jones, Roy W, Morris, John C, Raskin, Joel, Dowsett, Sherie A, Scheltens, Philip

“…The global impact of Alzheimer's disease (AD) continues to increase, and focused efforts are needed to address this immense public health challenge. National…”
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Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials by Atri, Alireza, Frölich, Lutz, Ballard, Clive, Tariot, Pierre N, Molinuevo, José Luis, Boneva, Neli, Windfeld, Kristian, Raket, Lars L, Cummings, Jeffrey L

“…IMPORTANCE: New therapeutic approaches for Alzheimer disease (AD) are needed. OBJECTIVE: To assess whether idalopirdine, a selective 5-hydroxytryptamine-6…”
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Risk of incident Alzheimer's disease in diabetic patients: a systematic review of prospective trials by Kopf, Daniel, Frölich, Lutz

“…Diabetes mellitus is an established risk factor of cognitive decline. This excess risk has frequently been attributed to cerebrovascular disease. The…”
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SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease by Brinkmalm, Ann, Brinkmalm, Gunnar, Honer, William G, Frölich, Lutz, Hausner, Lucrezia, Minthon, Lennart, Hansson, Oskar, Wallin, Anders, Zetterberg, Henrik, Blennow, Kaj, Öhrfelt, Annika

“…Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid…”
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The metabolism hypothesis of Alzheimer’s disease: from the concept of central insulin resistance and associated consequences to insulin therapy by Morgen, Katrin, Frölich, Lutz

“…The concept of central insulin resistance and dysfunctional insulin signaling in Alzheimer’s disease (AD) has been developed by Siegfried Hoyer in 1985–2000…”
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On the path to 2025: understanding the Alzheimer's disease continuum by Aisen, Paul S, Cummings, Jeffrey, Jack, Jr, Clifford R, Morris, John C, Sperling, Reisa, Frölich, Lutz, Jones, Roy W, Dowsett, Sherie A, Matthews, Brandy R, Raskin, Joel, Scheltens, Philip, Dubois, Bruno

“…Basic research advances in recent years have furthered our understanding of the natural history of Alzheimer's disease (AD). It is now recognized that…”
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Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer's disease by Frölich, Lutz, Wunderlich, Glen, Thamer, Claus, Roehrle, Michael, Garcia, Jr, Miguel, Dubois, Bruno

“…There are currently no approved treatments for the prodromal stage of Alzheimer's disease (AD). Approved symptomatic treatments for mild-to-moderate AD include…”
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Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type by Popp, Julius, Wolfsgruber, Steffen, Heuser, Isabella, Peters, Oliver, Hüll, Michael, Schröder, Johannes, Möller, Hans-Jürgen, Lewczuk, Piotr, Schneider, Anja, Jahn, Holger, Luckhaus, Christian, Perneczky, Robert, Frölich, Lutz, Wagner, Michael, Maier, Wolfgang, Wiltfang, Jens, Kornhuber, Johannes, Jessen, Frank

“…Abstract Increased peripheral and central nervous system cortisol levels have been reported in Alzheimer's disease (AD) and may reflect dysfunction of cerebral…”
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The future of Alzheimer's disease: the next 10 years by Hampel, Harald, Prvulovic, David, Teipel, Stefan, Jessen, Frank, Luckhaus, Christian, Frölich, Lutz, Riepe, Matthias W, Dodel, Richard, Leyhe, Thomas, Bertram, Lars, Hoffmann, Wolfgang, Faltraco, Frank

“…Alzheimer's disease (AD) is a fast growing world-wide epidemic. AD is a genetically complex, slowly progressive, and irreversible neurodegenerative disease of…”
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Evaluation of Sodium ( 23 Na) MR-imaging as a Biomarker and Predictor for Neurodegenerative Changes in Patients With Alzheimer's Disease by Mohamed, Sherif A, Herrmann, Katrin, Adlung, Anne, Paschke, Nadia, Hausner, Lucrezia, FrÖlich, Lutz, Schad, Lothar, Groden, Christoph, Kerl, Hans Ulrich

“…Sodium ( Na) MR imaging is a noninvasive MRI technique that has been shown to be sensitive to visualize biochemical information about tissue viability, their…”
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Effects of an app-based sensorimotor training in promoting neuroplasticity and neuropsychological functioning in frailty: A randomized controlled trial by Beier, Florian, Löffler, Martin, Nees, Frauke, Bekrater-Bodmann, Robin, Silvoni, Stefano, Desch, Simon, Löffler, Annette, Hausner, Lucrezia, Frölich, Lutz, Flor, Herta

“…•Age-related brain alterations may play a major role in frailty.•A neuroplasticity-based sensorimotor training could be beneficial in counteracting frailty and…”
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Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia by Frölich, Lutz, Peters, Oliver, Lewczuk, Piotr, Gruber, Oliver, Teipel, Stefan J, Gertz, Hermann J, Jahn, Holger, Jessen, Frank, Kurz, Alexander, Luckhaus, Christian, Hüll, Michael, Pantel, Johannes, Reischies, Friedel M, Schröder, Johannes, Wagner, Michael, Rienhoff, Otto, Wolf, Stefanie, Bauer, Chris, Schuchhardt, Johannes, Heuser, Isabella, Rüther, Eckart, Henn, Fritz, Maier, Wolfgang, Wiltfang, Jens, Kornhuber, Johannes

“…The progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia can be predicted by cognitive, neuroimaging, and cerebrospinal fluid…”
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European Academy of Neurology/European Alzheimer’s Disease Consortium position statement on diagnostic disclosure, biomarker counseling, and management of patients with mild cognitive impairment by Frederiksen, Kristian Steen, Nielsen, T. Rune, Winblad, Bengt, Schmidt, Reinhold, Kramberger, Milica G., Jones, Roy W., Hort, Jakub, Grimmer, Timo, Georges, Jean, Frölich, Lutz, Engelborghs, Sebastiaan, Dubois, Bruno, Waldemar, Gunhild

“…Background and purpose Careful counseling through the diagnostic process and adequate postdiagnostic support in patients with mild cognitive impairment (MCI)…”
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Sensory and motor correlates of frailty: dissociation between frailty phenotype and frailty index by Beier, Florian, Löffler, Martin, Nees, Frauke, Hausner, Lucrezia, Frölich, Lutz, Flor, Herta

“…Abstract Background Frailty has been associated with a decline in sensory and motor function. However, given that different frailty measures were shown to…”
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Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism by de Souza Silva, Maria A., Lenz, Bernd, Rotter, Andrea, Biermann, Teresa, Peters, Oliver, Ramirez, Alfredo, Jessen, Frank, Maier, Wolfgang, Hüll, Michael, Schröder, Johannes, Frölich, Lutz, Teipel, Stefan, Gruber, Oliver, Kornhuber, Johannes, Huston, Joseph P., Müller, Christian P., Schäble, Sandra

“…Impaired learning and memory performance is often found in aging as an early sign of dementia. It is associated with neuronal loss and reduced functioning of…”
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Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia by Kleineidam, Luca, Wagner, Michael, Guski, Jannis, Wolfsgruber, Steffen, Miebach, Lisa, Bickel, Horst, König, Hans‐Helmut, Weyerer, Siegfried, Lühmann, Dagmar, Kaduszkiewicz, Hanna, Luppa, Melanie, Röhr, Susanne, Pentzek, Michael, Wiese, Birgitt, Maier, Wolfgang, Scherer, Martin, Kornhuber, Johannes, Peters, Oliver, Frölich, Lutz, Wiltfang, Jens, Lewczuk, Piotr, Hüll, Michael, Ramirez, Alfredo, Jessen, Frank, Riedel‐Heller, Steffi G., Heser, Kathrin

“…Introduction Subjective cognitive decline (SCD) and depressive symptoms (DS) frequently co‐occur prior to dementia. However, the temporal sequence of their…”
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Apathy in patients with Alzheimer's disease is a cost‐driving factor by Kruse, Christopher, Maier, Franziska, Spottke, Annika, Bach, Jan‐Philipp, Bartels, Claudia, Buerger, Katharina, Fellgiebel, Andreas, Fliessbach, Klaus, Frölich, Lutz, Hausner, Lucrezia, Hellmich, Martin, Klöppel, Stefan, Klostermann, Arne, Kornhuber, Johannes, Laske, Christoph, Peters, Oliver, Priller, Josef, Richter‐Schmidinger, Tanja, Schneider, Anja, Shah‐Hosseini, Kija, Teipel, Stefan, Arnim, Christine A. F., Wiltfang, Jens, Wurp, Hendrik, Dodel, Richard, Jessen, Frank

“…Background Apathy is the most frequent neuropsychiatric symptom in patients with dementia of the Alzheimer's type (DAT). We analyzed the influence of apathy on…”
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BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study by Cognat, Emmanuel, Sabia, Séverine, Fayel, Alexandra, Lilamand, Matthieu, Handels, Ron, Fascendini, Sara, Bergh, Sverre, Frisoni, Giovanni B., Fabbo, Andrea, Tsolaki, Magdalina, Frölich, Lutz, Peters, Oliver, Merlo, Paola, Ciccone, Alfonso, Mecocci, Patrizia, Dumurgier, Julien, Defanti, Carlo A., Hugon, Jacques, Paquet, Claire

“…•What is the primary question addressed by this study?Do patients with severe behavioral and psychological symptoms of dementia show specific neuropsychiatric…”
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