Search Results - "Lutz, Werner K"

CYP2C9 genotype vs. metabolic phenotype for individual drug dosing--a correlation analysis using flurbiprofen as probe drug by Vogl, Silvia, Lutz, Roman W, Schönfelder, Gilbert, Lutz, Werner K

“…Currently, genotyping of patients for polymorphic enzymes responsible for metabolic elimination is considered a possibility to adjust drug dose levels. For a…”
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Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose–response relationships, exemplified for mutagenicity data by Lutz, Werner K., Lutz, Roman W.

“…Strongly sublinear dose–response relationships (slope increasing with dose) raise the question about a putative threshold dose below which no biologically…”
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Metabolic Profiling of Glucuronides in Human Urine by LC−MS/MS and Partial Least-Squares Discriminant Analysis for Classification and Prediction of Gender by Lutz, Ursula, Lutz, Roman W, Lutz, Werner K

“…Mass spectrometry (MS) is increasingly being used for metabolic profiling, but detection modes such as constant neutral loss or multiple reaction monitoring…”
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Nonmonotonic Dose-Response Relationships: Mechanistic Basis, Kinetic Modeling, and Implications for Risk Assessment by Conolly, Rory B., Lutz, Werner K.

“…Dose-response curves for the first interaction of a chemical with a biochemical target molecule are usually monotonic; i.e., they increase or decrease over the…”
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Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity by Lutz, Ursula, Bittner, Nataly, Ufer, Mike, Lutz, Werner K.

“…Drug–drug and food–drug interactions are often due to an inhibition or induction of drug-metabolizing cytochrome P450 (CYP) enzymes and may result in…”
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Correction: CYP2C9 genotype vs. metabolic phenotype for individual drug dosing--a correlation analysis using flurbiprofen as probe drug by Vogl, Silvia, Lutz, Roman W, Schönfelder, Gilbert, Lutz, Werner K

“…According to the study design, which also designated phenotyping for CYP2D6, 10 mg dextromethorphan in water (DEX, as dextromethorphan hydrobromide…”
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Ochratoxin A: 13-Week Oral Toxicity and Cell Proliferation in Male F344/N Rats by Rached, Eva, Hard, Gordon C., Blumbach, Kai, Weber, Klaus, Draheim, Regina, Lutz, Werner K., Özden, Sibel, Steger, Ulrich, Dekant, Wolfgang, Mally, Angela

“…Ochratoxin A (OTA) is nephrotoxic and a potent renal carcinogen. Male rats are most susceptible to OTA toxicity, and chronic administration of OTA (70 and 210…”
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Metabolite profiling in human urine by LC–MS/MS: Method optimization and application for glucuronides from dextromethorphan metabolism by Lutz, Ursula, Bittner, Nataly, Lutz, Roman W., Lutz, Werner K.

“…Analysis of human urine for specific compounds or metabolites is an established method for biomonitoring occupational or environmental exposures. Modern liquid…”
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Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease by Völkel, Wolfgang, Sicilia, Tina, Pähler, Axel, Gsell, W., Tatschner, Thomas, Jellinger, Kurt, Leblhuber, Friedrich, Riederer, Peter, Lutz, Werner K., Götz, Mario E.

“…In the last decade an important role for the progression of neuronal cell death in Alzheimer's disease (AD) has been ascribed to oxidative stress…”
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Drug interactions with mitotane by induction of CYP3A4 metabolism in the clinical management of adrenocortical carcinoma by Kroiss, Matthias, Quinkler, Marcus, Lutz, Werner K., Allolio, Bruno, Fassnacht, Martin

“…Summary Mitotane [1‐(2‐chlorophenyl)‐1‐(4‐chlorophenyl)‐2,2‐dichloroethane, (o,p’‐DDD)] is the only drug approved for the treatment for adrenocortical…”
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Strategies in case of positive in vivo results in genotoxicity testing by Thybaud, Véronique, MacGregor, James T., Müller, Lutz, Crebelli, Riccardo, Dearfield, Kerry, Douglas, George, Farmer, Peter B., Gocke, Elmar, Hayashi, Makoto, Lovell, David P., Lutz, Werner K., Marzin, Daniel, Moore, Martha, Nohmi, Takehiko, Phillips, David H., Van Benthem, Jan

“…At the 2009 International Workshop on Genotoxicity Testing in Basel, an expert group gathered to provide guidance on suitable follow-up tests to describe risk…”
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LC–MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation by Lutz, Ursula, Völkel, Wolfgang, Lutz, Roman W., Lutz, Werner K.

“…In order to establish a fast screening method for the determination of the CYP2D6 metabolic phenotype a sensitive LC–MS/MS assay to quantify dextromethorphan…”
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Comparative Assessment of the Inhibition of Recombinant Human CYP19 (Aromatase) by Azoles Used in Agriculture and as Drugs for Humans by Trösken, Eva R., Scholz, Karoline, Lutz, Roman W., Völkel, Wolfgang, Zarn, Jürg A., Lutz, Werner K.

“…Azoles (imidazoles and triazoles) are used as antifungal agents in agriculture and in medicine, and also for antiestrogen therapy, e.g., for breast cancer…”
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Different Types of Combination Effects for the Induction of Micronuclei in Mouse Lymphoma Cells by Binary Mixtures of the Genotoxic Agents MMS, MNU, and Genistein by Lutz, Werner K., Tiedge, Oliver, Lutz, Roman W., Stopper, Helga

“…Distinction between dose addition and response addition for the analysis of the toxicity of mixtures may allow differentiation of the components regarding…”
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The Viracept (nelfinavir)—Ethyl methanesulfonate case: A threshold risk assessment for human exposure to a genotoxic drug contamination? by Lutz, Werner K.

“…In May 2007, the F. Hoffmann-La Roche Company became aware of a contamination of Viracept (nelfinavir) tablets by the mutagenic DNA-ethylating agent ethyl…”
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Effect of Omeprazole and Dextromethorphan on the Urinary Metabolic Ratio of Flurbiprofen by Vogl, Silvia, Steinfath, Matthias, Lutz, Werner K., Schönfelder, Gilbert

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Biomarkers of Furan Exposure by Metabolic Profiling of Rat Urine with Liquid Chromatography-Tandem Mass Spectrometry and Principal Component Analysis by Kellert, Marco, Wagner, Silvia, Lutz, Ursula, Lutz, Werner K

“…Furan has been found in a number of heated food items and is carcinogenic in the liver of rats and mice. Estimates of human exposure on the basis of…”
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Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk +/− mouse lymphoma cells by Kellert, Marco, Brink, Andreas, Richter, Ingrid, Schlatter, Josef, Lutz, Werner K.

“…Furan is found in various food items and is cytotoxic and carcinogenic in the liver of rats and mice. Metabolism of furan includes the formation of an…”
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Comparison of lanosterol-14α-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles by Trösken, Eva R., Adamska, Magdalena, Arand, Michael, Zarn, Jürg A., Patten, Christopher, Völkel, Wolfgang, Lutz, Werner K.

“…Inhibition of fungal lanosterol-14α-demethylase (CYP51) is the working principle of the antifungal activity of azoles used in agriculture and medicine…”
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Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC–MS/MS method for the analysis of estradiol product formation by Trösken, Eva R., Fischer, Kathrin, Völkel, Wolfgang, Lutz, Werner K.

“…Azoles are used as fungicides in agriculture or antifungal drugs in medicine. Their therapeutic activity is based on the inhibition of fungal…”
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