Search Results - "Lutz, W. K."

Occurrence of Emodin, Chrysophanol and Physcion in Vegetables, Herbs and Liquors. Genotoxicity and Anti-genotoxicity of the Anthraquinones and of the Whole Plants by Mueller, S.O, Schmitt, M, Dekant, W, Stopper, H, Schlatter, J, Schreier, P, Lutz, W.K

“…1,8-Dihydroxyanthraquinones, present in laxatives, fungi imperfecti, Chinese herbs and possibly vegetables, are in debate as human carcinogens. We screened a…”
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Decreased tumor surveillance in perforin-deficient mice by van den Broek, M E, Kägi, D, Ossendorp, F, Toes, R, Vamvakas, S, Lutz, W K, Melief, C J, Zinkernagel, R M, Hengartner, H

“…Immune surveillance against tumors usually depends on T cell recognition of tumor antigens presented by major histocompatibility complex (MHC) molecules,…”
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Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets by Eder, E., Wacker, M., Lutz, U., Nair, J., Fang, X., Bartsch, H., Beland, F.A., Schlatter, J., Lutz, W.K.

“…Both animal and epidemiological studies support an effect of fatty acid composition in the diet on cancer development, in particular on colon cancer. We…”
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Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts by Otteneder, M, Lutz, W K

“…The quantitative relationship between DNA adducts and tumor incidence is evaluated in this review. All available data on DNA adduct levels determined after…”
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A true threshold dose in chemical carcinogenesis cannot be defined for a population, irrespective of the mode of action by Lutz, W K

“…Strongly sigmoidal (S-shaped) dose-cancer incidence relationships are often observed in animal bioassays for carcinogenicity. If a genotoxic contribution is…”
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Discrimination between genotoxicity and cytotoxicity in the induction of DNA double-strand breaks in cells treated with etoposide, melphalan, cisplatin, potassium cyanide, Triton X-100, and γ-irradiation by Vock, E.H, Lutz, W.K, Hormes, P, Hoffmann, H.D, Vamvakas a, S

“…The dose–response relationships for DNA fragmentation (assessed by pulsed-field gel electrophoresis, PFGE) and for viability (evaluated by measuring the…”
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Dose-response relationships in chemical carcinogenesis reflect differences in individual susceptibility. Consequences for cancer risk assessment, extrapolation, and prevention by Lutz, W K

“…The shape of the dose-cancer incidence curve observed in an animal bioassay for carcinogenicity of a chemical is the result of a superposition of various…”
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On the Role of DNA Double-Strand Breaks in Toxicity and Carcinogenesis by Vamvakas, Spiros, Vock, Esther H., Lutz, Werner K.

“…Abstract DNA double-strand breaks are associated with various endogenous processes, such as transcription, recombination, replication, and with the process of…”
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The carcinogenic potential of ethyl carbamate (urethane): risk assessment at human dietary exposure levels by Schlatter, J, Lutz, W K

“…Ethyl carbamate is found in fermented foods: bread contains 3-15 ng/g, stone-fruit brandies 200-20,000 ng/g, and about one-third of table-wine samples analysed…”
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Dose-response relationship and low dose extrapolation in chemical carcinogenesis by Lutz, W K

“…Data supporting various dose-response relationships in chemical carcinogenesis are summarized. General principles are derived to explain the relationships…”
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Nonmonotonic Dose-Response Relationships: Mechanistic Basis, Kinetic Modeling, and Implications for Risk Assessment by Conolly, Rory B., Lutz, Werner K.

“…Dose-response curves for the first interaction of a chemical with a biochemical target molecule are usually monotonic; i.e., they increase or decrease over the…”
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Chemical carcinogens and overnutrition in diet-related cancer by Lutz, W K, Schlatter, J

“…The intake of known dietary carcinogens was compiled and the cancer risk was estimated on the basis of carcinogenic potencies in animals as derived from the…”
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Discrimination between genotoxicity and cytotoxicity for the induction of DNA double-strand breaks in cells treated with aldehydes and diepoxides by Vock, E.H, Lutz, W.K, Ilinskaya, O, Vamvakas, S

“…The time-dependent dose–response relationships for the induction of DNA double-strand breaks (DSB) assessed by pulsed-field gel electrophoresis (PFGE) and for…”
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Linear dose-response relationship for DNA adducts in rat liver from chronic exposure to aflatoxin B1 by Buss, P, Caviezel, M, Lutz, W K

“…Male F-344 rats were given [3H]aflatoxin B1 (AFB1) in the drinking water at three exposure levels (0.02, 0.6, 20 micrograms/l, resulting in average dose levels…”
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Factors affecting the genotoxic potency ranking of natural anthraquinones in mammalian cell culture systems by Mueller, Stefan O, Lutz, Werner K, Stopper, Helga

“…We had reported that the plant-derived 1,8-dihydroxyanthraquinone derivatives, emodin and danthron, were clearly genotoxic in mouse lymphoma L5178Y cells,…”
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Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene elicits a specific T cell-dependent immune response by WACK, Christiane, KIRST, Annette, BECKER, Jürgen C, LUTZ, Werner K, BRÖCKER, Eva-B, FISCHER, Wolfgang H

“…An empirically established chemoimmunotherapy for metastatic melanoma combines the systemic administration of the chemotherapeutic agent dacarbazine (DTIC)…”
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Investigation of the Induction of DNA Double-Strand Breaks by Methylenediphenyl-4,4′-diisocyanate in Cultured Human Lung Epithelial Cells by Vock, E. H., Vamvakas, S., Gahlmann, R., Lutz, W. K.

“…The question was addressed whether methylenediphenyl-4,4′-di-isocyanate (MDI), a bifunctional electrophile, can induce DNA double-strand breaks (DSB) by repair…”
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Investigation of the covalent binding of styrene-7,8-oxide to DNA in rat and mouse by Cantoreggi, S, Lutz, W K

“…Styrene-7,8-oxide (SO), the main intermediate metabolite of styrene, induces hyperkeratosis and tumors in the forestomach of rats and mice upon chronic…”
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Chemoimmunotherapy for melanoma with dacarbazine and 2,4-dinitrochlorobenzene: results from a murine tumour model by Wack, C, Becker, J C, Bröcker, E B, Lutz, W K, Fischer, W H

“…An empirically established chemoimmunotherapy that combines the epifocal application of the contact sensitizer dinitrochlorobenzene (DNCB) to cutaneous…”
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Significance of DNA Adducts at Low Dose: Shortening the Time to Spontaneous Tumor Occurrence by Lutz, Werner K., Gaylor, David

“…Formation and repair of adducts from DNA-reactive carcinogens as well as induction of genetic changes is expected to be proportional to dose as long as the…”
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