Search Results - "Lutz, Thomas A"

Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus by Lutz, Thomas A.

“…Although no single animal model replicates all aspects of diabetes mellitus in humans, animal models are essential for the study of energy balance and…”
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The role of amylin in the control of energy homeostasis by Lutz, Thomas A

“…Amylin is an important player in the control of nutrient fluxes. Amylin reduces eating via a meal size effect by promoting meal-ending satiation. This effect…”
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Amylin: Pharmacology, Physiology, and Clinical Potential by Hay, Debbie L, Chen, Steve, Lutz, Thomas A, Parkes, David G, Roth, Jonathan D

“…Amylin is a pancreatic β-cell hormone that produces effects in several different organ systems. Here, we review the literature in rodents and in humans on…”
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Translational value of animal models of obesity—Focus on dogs and cats by Osto, Melania, Lutz, Thomas A.

“…A prolonged imbalance between a relative increase in energy intake over a decrease in energy expenditure results in the development of obesity; extended…”
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Overview of animal models of obesity by Lutz, Thomas A, Woods, Stephen C

“…The focus of this overview is on the animal models of obesity most commonly utilized in research. The models include monogenic models in the leptin pathway,…”
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Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity by Pretz, Dominik, Le Foll, Christelle, Rizwan, Mohammed Z., Lutz, Thomas A., Tups, Alexander

“…Obesity has emerged as a major risk factor for insulin resistance leading to the development of type 2 diabetes (T2D). The condition is characterized by high…”
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Ghrelin receptor inverse agonists as a novel therapeutic approach against obesity‐related metabolic disease by Abegg, Kathrin, Bernasconi, Lara, Hutter, Melanie, Whiting, Lynda, Pietra, Claudio, Giuliano, Claudio, Lutz, Thomas A., Riediger, Thomas

“…Aims Ghrelin is implicated in the control of energy balance and glucose homeostasis. The ghrelin receptor exhibits ligand‐independent constitutive activity,…”
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Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder by Romano, Adele, Micioni Di Bonaventura, Maria Vittoria, Gallelli, Cristina Anna, Koczwara, Justyna Barbara, Smeets, Dorien, Giusepponi, Maria Elena, De Ceglia, Marialuisa, Friuli, Marzia, Micioni Di Bonaventura, Emanuela, Scuderi, Caterina, Vitalone, Annabella, Tramutola, Antonella, Altieri, Fabio, Lutz, Thomas A, Giudetti, Anna Maria, Cassano, Tommaso, Cifani, Carlo, Gaetani, Silvana

“…Binge eating disorder (BED) is the most frequent eating disorder, for which current pharmacotherapies show poor response rates and safety concerns, thus…”
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The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression by Miranda, Melroy X, van Tits, Lambertus J, Lohmann, Christine, Arsiwala, Tasneem, Winnik, Stephan, Tailleux, Anne, Stein, Sokrates, Gomes, Ana P, Suri, Vipin, Ellis, James L, Lutz, Thomas A, Hottiger, Michael O, Sinclair, David A, Auwerx, Johan, Schoonjans, Kristina, Staels, Bart, Lüscher, Thomas F, Matter, Christian M

“…The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are…”
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Pancreatic signals controlling food intake; insulin, glucagon and amylin by Woods, Stephen C, Lutz, Thomas A, Geary, Nori, Langhans, Wolfgang

“…The control of food intake and body weight by the brain relies upon the detection and integration of signals reflecting energy stores and fluxes, and their…”
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A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models by Wirth, Fabian, Heitz, Fabrice D., Seeger, Christine, Combaluzier, Ioana, Breu, Karin, Denroche, Heather C., Thevenet, Julien, Osto, Melania, Arosio, Paolo, Kerr-Conte, Julie, Verchere, C. Bruce, Pattou, François, Lutz, Thomas A., Donath, Marc Y., Hock, Christoph, Nitsch, Roger M., Grimm, Jan

“…In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood…”
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Specific amino acids inhibit food intake via the area postrema or vagal afferents by Jordi, Josua, Herzog, Brigitte, Camargo, Simone M. R., Boyle, Christina N., Lutz, Thomas A., Verrey, François

“…Key points •  Proteins are more satiating than fats or lipids. Proteins are built by the 20 proteogenic amino acids. •  Here, we identified l‐arginine,…”
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Effects of acute administration of trimethylamine N-oxide on endothelial function: a translational study by Jomard, Anne, Liberale, Luca, Doytcheva, Petia, Reiner, Martin F., Müller, Daniel, Visentin, Michele, Bueter, Marco, Lüscher, Thomas F., Vettor, Roberto, Lutz, Thomas A., Camici, Giovanni G., Osto, Elena

“…Elevated circulating levels of nutrient-derived trimethylamine N-oxide (TMAO) have been associated with the onset and progression of cardiovascular disease by…”
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Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery by Ratner, Cecilia, Skov, Louise J, Raida, Zindy, Bächler, Thomas, Bellmann-Sickert, Kathrin, Le Foll, Christelle, Sivertsen, Bjørn, Dalbøge, Louise S, Hartmann, Bolette, Beck-Sickinger, Annette G, Madsen, Andreas N, Jelsing, Jacob, Holst, Jens J, Lutz, Thomas A, Andrews, Zane B, Holst, Birgitte

“…Neurotensin (NT) is a peptide expressed in the brain and in the gastrointestinal tract. Brain NT inhibits food intake, but the effects of peripheral NT are…”
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The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping by Braegger, Fiona E., Asarian, Lori, Dahl, Kirsten, Lutz, Thomas A., Boyle, Christina N.

“…Amylin reduces meal size by activating noradrenergic neurons in the area postrema (AP). Neurons in the AP also mediate the eating‐inhibitory effects of salmon…”
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Serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss by Zini, Eric, Salesov, Elena, Willing, Anke, Palizzotto, Carlo, Lutz, Thomas A., Reusch, Claudia E.

“…Background Measurement of serum concentrations of insulin‐like growth factor (IGF)‐1 is used to diagnose acromegaly in cats. Hypothesis Changes of body weight…”
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The Use of Rat and Mouse Models in Bariatric Surgery Experiments by Lutz, Thomas A, Bueter, Marco

“…Animal models have been proven to be a crucial tool for investigating the physiological mechanisms underlying bariatric surgery in general and individual…”
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Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine by Osto, Melania, Abegg, Kathrin, Bueter, Marco, le Roux, Carel W, Cani, Patrice D, Lutz, Thomas A

“…Abstract Roux-en-Y gastric bypass (RYGB) surgery might modify the gut microbiota composition differently in the three distinct anatomical sections of the small…”
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The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats by Borner, Tito, Loi, Laura, Pietra, Claudio, Giuliano, Claudio, Lutz, Thomas A, Riediger, Thomas

“…The gastric hormone ghrelin positively affects energy balance by increasing food intake and reducing energy expenditure. Ghrelin mimetics are a possible…”
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Characterization of Antibodies against Receptor Activity-Modifying Protein 1 (RAMP1): A Cautionary Tale by Hendrikse, Erica R, Rees, Tayla A, Tasma, Zoe, Garelja, Michael L, Siow, Andrew, Harris, Paul W R, Pawlak, John B, Caron, Kathleen M, Blakeney, Elizabeth S, Russo, Andrew F, Sowers, Levi P, Lutz, Thomas A, Le Foll, Christelle, Walker, Christopher S, Hay, Debbie L

“…Calcitonin gene-related peptide (CGRP) is a key component of migraine pathophysiology, yielding effective migraine therapeutics. CGRP receptors contain a core…”
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