Search Results - "Lutz, M. W."

Using Genetics to Enable Studies on the Prevention of Alzheimer's Disease by Crenshaw, D G, Gottschalk, W K, Lutz, M W, Grossman, I, Saunders, A M, Burke, J R, Welsh-Bohmer, K A, Brannan, S K, Burns, D K, Roses, A D

“…Curing Alzheimer's disease (AD) remains an elusive goal; indeed, it may even prove to be impossible, given the nature of the disease. Although modulating…”
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A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease by Roses, A D, Lutz, M W, Amrine-Madsen, H, Saunders, A M, Crenshaw, D G, Sundseth, S S, Huentelman, M J, Welsh-Bohmer, K A, Reiman, E M

“…The ɛ4 allele of the apolipoprotein E ( APOE ) gene is currently the strongest and most highly replicated genetic factor for risk and age of onset of…”
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Quantitation of Hepatitis B Viremia and Emergence of YMDD Variants in Patients with Chronic Hepatitis B Treated with Lamivudine by Gauthier, Josée, Bourne, Eric J., Lutz, Michael W., Crowther, Lynn M., Dienstag, Jules L., Brown, Nathaniel A., Condreay, Lynn D.

“…Hepatitis B viremia and emergence of hepatitis B virus (HBV) YMDD variants with reduced susceptibility to lamivudine were analyzed in patient sera from a phase…”
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Two Sensitive PCR-Based Methods for Detection of Hepatitis B Virus Variants Associated with Reduced Susceptibility to Lamivudine by ALLEN, M. I, GAUTHIER, J, DESLAURIERS, M, BOURNE, E. J, CARRICK, K. M, BALDANTI, F, ROSS, L. L, LUTZ, M. W, CONDREAY, L. D

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing by Davies, G, Harris, S E, Reynolds, C A, Payton, A, Knight, H M, Liewald, D C, Lopez, L M, Luciano, M, Gow, A J, Corley, J, Henderson, R, Murray, C, Pattie, A, Fox, H C, Redmond, P, Lutz, M W, Chiba-Falek, O, Linnertz, C, Saith, S, Haggarty, P, McNeill, G, Ke, X, Ollier, W, Horan, M, Roses, A D, Ponting, C P, Porteous, D J, Tenesa, A, Pickles, A, Starr, J M, Whalley, L J, Pedersen, N L, Pendleton, N, Visscher, P M, Deary, I J

“…Cognitive decline is a feared aspect of growing old. It is a major contributor to lower quality of life and loss of independence in old age. We investigated…”
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Genotypic Effects of the TOMM40’523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study by Zou, H., Luo, Sheng, Liu, H., Lutz, M. W., Bennett, D. A., Plassman, B. L., Welsh-Bohmer, K. A.

“…Background The 523 poly-T length polymorphism (rs10524523) in TOMM40 has been reported to influence longitudinal cognitive test performance within APOE ε3/3…”
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Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms by Mastaglia, F.L, Rojana-udomsart, A, James, I, Needham, M, Day, T.J, Kiers, L, Corbett, J.A, Saunders, A.M, Lutz, M.W, Roses, A.D

“…Abstract A polyT repeat in an intronic polymorphism (rs10524523) in the TOMM40 gene, which encodes an outer mitochondrial membrane translocase involved in the…”
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Characterization of alpha-1 adrenoceptor subtypes in human and canine prostate membranes by Goetz, A S, Lutz, M W, Rimele, T J, Saussy, Jr, D L

“…Experiments were designed to characterize the predominant subtype of alpha-1 adrenoceptors in human and canine prostate tissue. The chemical…”
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Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype by Saussy, Jr, D L, Goetz, A S, Queen, K L, King, H K, Lutz, M W, Rimele, T J

“…The activity of a series of busprione analogs at recombinant and rat thoracic aorta alpha-1 adrenoceptors was investigated. Compound affinity for recombinant…”
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A pharmacodynamic model to investigate the structure-activity profile of a series of novel opioid analgesics by Lutz, M W, Morgan, P H, James, M K, Feldman, P L, Brackeen, M F, Lahey, A P, James, S V, Bilotta, J M, Pressley, J C

“…A simple mathematical model of analgesia in the rat is developed and utilized to determine quantitative structure-activity relationships for a series of novel…”
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Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics by FELDMAN, P. L, JAMES, M. K, BRACKEEN, M. F, BILOTTA, J. M, SCHUSTER, S. V, LAHEY, A. P, LUTZ, M. W, JOHNSON, M. R, LEIGHTON, H. J

“…In an effort to discover a potent ultrashort-acting mu opioid analgetic that is capable of metabolizing to an inactive species independent of hepatic function,…”
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Interactions of 1263W94 with Other Antiviral Agents in Inhibition of Human Cytomegalovirus Replication by SELLESETH, Dean W, TALARICO, Christine L, MILLER, Teresa, LUTZ, Michael W, BIRON, Karen K, HARVEY, Robert J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Assessment of the COBAS Amplicor HBV Monitor Test for Quantitation of Serum Hepatitis B Virus DNA Levels by LOPEZ, Vincent A, BOURNE, Eric J, LUTZ, Michael W, CONDREAY, Lynn D

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Amplifying Efficiency and Accuracy in Dementia Drug Development by Lerch, O., Levine, S. Z., Sivakumaran, S., Lutz, M. W., Chiba-Falek, O., Mazer, N., Bairu, M., Haraldsen, I. R. J. Hebold, Rossini, P. M., Snyder, P. J., Bouteiller, J., Khachaturian, Z. S., Khachaturian, Ara S.

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The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease by Linnertz, Colton, Lutz, Michael W, Ervin, John F, Allen, Jawara, Miller, Natalie R, Welsh-Bohmer, Kathleen A, Roses, Allen D, Chiba-Falek, Ornit

“…The molecular genetic basis that leads to Lewy Body (LB) pathology in 15-20% of Alzheimer disease cases (LBV/AD) was largely unknown. Alpha-synuclein (SNCA)…”
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Editorial: Amplifying Efficiency and Accuracy in Dementia Drug Development by Lerch, O, Levine, S Z, Sivakumaran, S, Lutz, M W, Chiba-Falek, O, Mazer, N, Bairu, M, Hebold Haraldsen, I R J, Rossini, P M, Snyder, P J, Bouteiller, J, Khachaturian, Z S, Khachaturian, A S

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Clinical research in dementia: A perspective on implementing innovation by Boccardi, Marina, Handels, Ron, Gold, Michael, Grazia, Alice, Lutz, Michael W., Martin, Mike, Nosheny, Rachel, Robillard, Julie M., Weidner, Wendy, Alexandersson, Jan, Thyrian, Jochen René, Winblad, Bengt, Barbarino, Paola, Khachaturian, Ara S., Teipel, Stefan

“…The increasing global prevalence of dementia demands concrete actions that are aimed strategically at optimizing processes that drive clinical innovation. The…”
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Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity? by Lyall, D M, Harris, S E, Bastin, M E, Muñoz Maniega, S, Murray, C, Lutz, M W, Saunders, A M, Roses, A D, Valdés Hernández, M del C, Royle, N A, Starr, J M, Porteous, D J, Wardlaw, J M, Deary, I J

“…Genetic polymorphisms in the APOE ɛ and TOMM40 ‘523’ poly-T repeat gene loci have been associated with significantly increased risk of Alzheimer’s disease…”
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Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter? by Hunter, Jaimie C., Handing, Elizabeth P., Casanova, Ramon, Kuchibhatla, Maragatha, Lutz, Michael W., Saldana, Santiago, Plassman, Brenda L., Hayden, Kathleen M.

“…We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study. Health…”
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The Cubic Ternary Complex Receptor-Occupancy Model III. Resurrecting Efficacy by Weiss, Jack M., Morgan, Paul H., Lutz, Michael W., Kenakin, Terry P.

“…Early work in pharmacology characterized the interaction of receptors and ligands in terms of two parameters, affinity and efficacy, an approach we term the…”
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