Search Results - "Lutz, Katie A."

Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension by Zhu, Na, Pauciulo, Michael W, Welch, Carrie L, Lutz, Katie A, Coleman, Anna W, Gonzaga-Jauregui, Claudia, Wang, Jiayao, Grimes, Joseph M, Martin, Lisa J, He, Hua, Shen, Yufeng, Chung, Wendy K, Nichols, William C

“…Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary…”
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Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease by Zhu, Na, Welch, Carrie L, Wang, Jiayao, Allen, Philip M, Gonzaga-Jauregui, Claudia, Ma, Lijiang, King, Alejandra K, Krishnan, Usha, Rosenzweig, Erika B, Ivy, D Dunbar, Austin, Eric D, Hamid, Rizwan, Pauciulo, Michael W, Lutz, Katie A, Nichols, William C, Reid, Jeffrey G, Overton, John D, Baras, Aris, Dewey, Frederick E, Shen, Yufeng, Chung, Wendy K

“…Pulmonary arterial hypertension (PAH) is a rare disease characterized by distinctive changes in pulmonary arterioles that lead to progressive pulmonary…”
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Correction to: Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension by Zhu, Na, Pauciulo, Michael W, Welch, Carrie L, Lutz, Katie A, Coleman, Anna W, Gonzaga-Jauregui, Claudia, Wang, Jiayao, Grimes, Joseph M, Martin, Lisa J, He, Hua, Shen, Yufeng, Chung, Wendy K, Nichols, William C

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Correction to: Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH by Zhu, Na, Swietlik, Emilia M, Welch, Carrie L, Pauciulo, Michael W, Hagen, Jacob J, Zhou, Xueya, Guo, Yicheng, Karten, Johannes, Pandya, Divya, Tilly, Tobias, Lutz, Katie A, Martin, Jennifer M, Treacy, Carmen M, Rosenzweig, Erika B, Krishnan, Usha, Coleman, Anna W, Gonzaga-Jauregui, Claudia, Lawrie, Allan, Trembath, Richard C, Wilkins, Martin R, Morrell, Nicholas W, Shen, Yufeng, Gräf, Stefan, Nichols, William C, Chung, Wendy K

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RASA3 is a candidate gene in sickle cell disease‐associated pulmonary hypertension and pulmonary arterial hypertension by Prohaska, Clare C., Zhang, Xu, Schwantes‐An, Tae‐Hwi L., Stearman, Robert S., Hooker, Stanley, Kittles, Rick A., Aldred, Micheala A., Lutz, Katie A., Pauciulo, Michael W., Nichols, William C., Desai, Ankit A., Gordeuk, Victor R., Machado, Roberto F.

“…Pulmonary hypertension (PH) is associated with significant morbidity and mortality. RASA3 is a GTPase activating protein integral to angiogenesis and…”
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The angiostatic peptide endostatin enhances mortality risk prediction in pulmonary arterial hypertension by Simpson, Catherine E, Griffiths, Megan, Yang, Jun, Nies, Melanie K, Vaidya, R Dhananjay, Brandal, Stephanie, Martin, Lisa J, Pauciulo, Michael W, Lutz, Katie A, Coleman, Anna W, Austin, Eric D, Ivy, D Dunbar, Nichols, William C, Everett, Allen D, Hassoun, Paul M, Damico, Rachel L

“…Currently available noninvasive markers for assessing disease severity and mortality risk in pulmonary arterial hypertension (PAH) are unrelated to fundamental…”
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Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival by Yang, Jun, Ambade, Anjira S., Nies, Melanie, Griffiths, Megan, Damico, Rachel, Vaidya, Dhananjay, Brandal, Stephanie, Pauciulo, Michael W., Lutz, Katie A., Coleman, Anna W., Nichols, William C., Austin, Eric D., Ivy, Dunbar, Hassoun, Paul M., Everett, Allen D.

“…Hepatoma‐derived growth factor (HDGF) was previously shown to be associated with increased mortality in a small study of idiopathic and connective tissue…”
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COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study by Simpson, Catherine E., Griffiths, Megan, Yang, Jun, Nies, Melanie K., Vaidya, Dhananjay, Brandal, Stephanie, Martin, Lisa J., Pauciulo, Michael W., Lutz, Katie A., Coleman, Anna W., Austin, Eric D., Ivy, D. Dunbar, Nichols, William C., Everett, Allen D., Hassoun, Paul M., Damico, Rachel L.

“…Endostatin (ES) is a circulating peptide derived from collagen XVIII alpha 1 (COL18A1) known to inhibit angiogenesis [1, 2]. Decreased angiogenesis is a…”
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United States Pulmonary Hypertension Scientific Registry (USPHSR): rationale, design, and clinical implications by Elliott, C. Gregory, Austin, Eric D., Badesch, David, Badlam, Jessica, Benza, Raymond L., Chung, Wendy K., Farber, Harrison W., Feldkircher, Kathy, Frost, Adaani E., Poms, Abby D., Lutz, Katie A., Pauciulo, Michael W., Yu, Chang, Nichols, William C.

“…Diagnostic World Health Organization (WHO) Group 1 pulmonary arterial hypertension (PAH) and Diagnostic Group 1' pulmonary veno-occlusive disease (PVOD) and/or…”
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Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension by Potus, François, Pauciulo, Michael W., Cook, Elina K., Zhu, Na, Hsieh, Alexander, Welch, Carrie L., Shen, Yufeng, Tian, Lian, Lima, Patricia, Mewburn, Jeffrey, D’Arsigny, Christine L., Lutz, Katie A., Coleman, Anna W., Damico, Rachel, Snetsinger, Brooke, Martin, Ashley Y., Hassoun, Paul M., Nichols, William C., Chung, Wendy K., Rauh, Michael J., Archer, Stephen L.

“…BACKGROUND:Pulmonary arterial hypertension (PAH) is a lethal vasculopathy. Hereditary cases are associated with germline mutations in BMPR2 and 16 other genes…”
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Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension by Simpson, Catherine E, Chen, Jenny Y, Damico, Rachel L, Hassoun, Paul M, Martin, Lisa J, Yang, Jun, Nies, Melanie, Griffiths, Megan, Vaidya, R Dhananjay, Brandal, Stephanie, Pauciulo, Michael W, Lutz, Katie A, Coleman, Anna W, Austin, Eric D, Ivy, Dunbar D, Nichols, William C, Everett, Allen D

“…The pro-inflammatory cytokine interleukin (IL)-6 has been associated with outcomes in small pulmonary arterial hypertension (PAH) cohorts composed largely of…”
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Multiple Biomarkers Are Equivalent to Clinical Pulmonary Arterial Hypertension Survival Risk Models by Griffiths, Megan, Simpson, Catherine E., Yang, Jun, Vaidya, Dhananjay, Nies, Melanie K., Brandal, Stephanie, Damico, Rachel, Hassoun, Paul, Ivy, Dunbar D., Austin, Eric D., Pauciulo, Michael W., Lutz, Katie A., Martin, Lisa J., Rosenzweig, Erika B., Benza, Raymond L., Nichols, William C., Manlhiot, Cedric, Everett, Allen D.

“…Risk assessment in pulmonary arterial hypertension (PAH) is fundamental to guiding treatment and improved outcomes. Clinical models are excellent at…”
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Exome Sequencing in Children With Pulmonary Arterial Hypertension Demonstrates Differences Compared With Adults by Zhu, Na, Gonzaga-Jauregui, Claudia, Welch, Carrie L, Ma, Lijiang, Qi, Hongjian, King, Alejandra K, Krishnan, Usha, Rosenzweig, Erika B, Ivy, D Dunbar, Austin, Eric D, Hamid, Rizwan, Nichols, William C, Pauciulo, Michael W, Lutz, Katie A, Sawle, Ashley, Reid, Jeffrey G, Overton, John D, Baras, Aris, Dewey, Frederick, Shen, Yufeng, Chung, Wendy K

“…Pulmonary arterial hypertension (PAH) is a rare disease characterized by pulmonary arteriole remodeling, elevated arterial pressure and resistance, and…”
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SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics by Sangam, Shreya, Sun, Xutong, Schwantes-An, Tae-Hwi, Yegambaram, Manivannan, Lu, Qing, Shi, Yinan, Cook, Todd, Fisher, Amanda, Frump, Andrea L, Coleman, Anna, Sun, Yanan, Liang, Shuxin, Crawford, Howard, Lutz, Katie A, Maun, Avinash D, Pauciulo, Michael W, Karnes, Jason H, Chaudhary, Ketul R, Stewart, Duncan J, Langlais, Paul R, Jain, Mohit, Alotaibi, Mona, Lahm, Tim, Jin, Yan, Gu, Haiwei, Tang, Haiyang, Nichols, William C, Black, Stephen M, Desai, Ankit A

“…Genetic studies suggest that SOX17 (SRY-related HMG-box 17) deficiency increases pulmonary arterial hypertension (PAH) risk. On the basis of pathological roles…”
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Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension by Toshner, Mark, Church, Colin, Harbaum, Lars, Rhodes, Christopher, Villar Moreschi, Sofia S, Liley, James, Jones, Rowena, Arora, Amit, Batai, Ken, Desai, Ankit A, Coghlan, John G, Gibbs, J Simon R, Gor, Dee, Gräf, Stefan, Harlow, Louise, Hernandez-Sanchez, Jules, Howard, Luke S, Humbert, Marc, Karnes, Jason, Kiely, David G, Kittles, Rick, Knightbridge, Emily, Lam, Brian, Lutz, Katie A, Nichols, William C, Pauciulo, Michael W, Pepke-Zaba, Joanna, Suntharalingam, Jay, Soubrier, Florent, Trembath, Richard C, Schwantes-An, Tae-Hwi L, Wort, S John, Wilkins, Martin R, Gaine, Sean, Morrell, Nicholas W, Corris, Paul A

“…Inflammation and dysregulated immunity are important in the development of pulmonary arterial hypertension (PAH). Compelling preclinical data supports the…”
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United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics by Badlam, Jessica B, Badesch, David B, Austin, Eric D, Benza, Raymond L, Chung, Wendy K, Farber, Harrison W, Feldkircher, Kathy, Frost, Adaani E, Poms, Abby D, Lutz, Katie A, Pauciulo, Michael W, Yu, Chang, Nichols, William C, Elliott, C Gregory

“…The treatment, genotyping, and phenotyping of patients with World Health Organization Group 1 pulmonary arterial hypertension (PAH) have evolved dramatically…”
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ST2 Is a Biomarker of Pediatric Pulmonary Arterial Hypertension Severity and Clinical Worsening by Griffiths, Megan, Yang, Jun, Simpson, Catherine E., Vaidya, Dhananjay, Nies, Melanie, Brandal, Stephanie, Damico, Rachel, Ivy, D. Dunbar, Austin, Eric D., Pauciulo, Michael W., Lutz, Katie A., Rosenzweig, Erika B., Hirsch, Russel, Yung, Delphine, Nichols, William C., Everett, Allen D.

“…Pediatric pulmonary hypertension is a severe disease defined by sustained elevation of pulmonary artery pressures and pulmonary vascular resistance (PVR)…”
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Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension by Hong, Jason, Medzikovic, Lejla, Sun, Wasila, Wong, Brenda, Ruffenach, Grégoire, Rhodes, Christopher J, Brownstein, Adam, Liang, Lloyd L, Aryan, Laila, Li, Min, Vadgama, Arjun, Kurt, Zeyneb, Schwantes-An, Tae-Hwi, Mickler, Elizabeth A, Gräf, Stefan, Eyries, Mélanie, Lutz, Katie A, Pauciulo, Michael W, Trembath, Richard C, Perros, Frédéric, Montani, David, Morrell, Nicholas W, Soubrier, Florent, Wilkins, Martin R, Nichols, William C, Aldred, Micheala A, Desai, Ankit A, Trégouët, David-Alexandre, Umar, Soban, Saggar, Rajan, Channick, Richard, Tuder, Rubin M, Geraci, Mark W, Stearman, Robert S, Yang, Xia, Eghbali, Mansoureh

“…Integrative multiomics can elucidate pulmonary arterial hypertension (PAH) pathobiology, but procuring human PAH lung samples is rare. We leveraged…”
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Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension by Tang, Haiyang, Gupta, Akash, Morrisroe, Seth A, Bao, Changlei, Schwantes-An, Tae-Hwi, Gupta, Geetanjali, Liang, Shuxin, Sun, Yanan, Chu, Aiai, Luo, Ang, Ramamoorthi Elangovan, Venkateswaran, Sangam, Shreya, Shi, Yinan, Naidu, Samisubbu R, Jheng, Jia-Rong, Ciftci-Yilmaz, Sultan, Warfel, Noel A, Hecker, Louise, Mitra, Sumegha, Coleman, Anna W, Lutz, Katie A, Pauciulo, Michael W, Lai, Yen-Chun, Javaheri, Ali, Dharmakumar, Rohan, Wu, Wen-Hui, Flaherty, Daniel P, Karnes, Jason H, Breuils-Bonnet, Sandra, Boucherat, Olivier, Bonnet, Sebastien, Yuan, Jason X-J, Jacobson, Jeffrey R, Duarte, Julio D, Nichols, William C, Garcia, Joe G N, Desai, Ankit A

“…The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about the role of…”
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Biomarkers of Pulmonary Hypertension Are Altered in Children with Down Syndrome and Pulmonary Hypertension by Griffiths, Megan, Yang, Jun, Vaidya, Dhananjay, Nies, Melanie, Brandal, Stephanie, Ivy, D. Dunbar, Hickey, Francis, Wolter-Warmerdam, Kristine, Austin, Eric D., Mullen, Mary, Pauciulo, Michael W., Lutz, Katie A., Rosenzweig, Erika B., Hirsch, Russel, Yung, Delphine, Nichols, William C., Everett, Allen D.

“…To evaluate the performance of pulmonary hypertension (PH) biomarkers in children with Down syndrome, an independent risk factor for PH, in whom biomarker…”
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