Search Results - "Lutton, Evan M."
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Trafficking of adeno‐associated virus vectors across a model of the blood–brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells
Published in Journal of neurochemistry (01-01-2017)“…Developing therapies for central nervous system (CNS) diseases is exceedingly difficult because of the blood–brain barrier (BBB). Notably, emerging…”
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Acute administration of catalase targeted to ICAM-1 attenuates neuropathology in experimental traumatic brain injury
Published in Scientific reports (19-06-2017)“…Traumatic brain injury (TBI) contributes to one third of injury related deaths in the US. Treatment strategies for TBI are supportive, and the pathophysiology…”
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Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain Injury
Published in Frontiers in cellular neuroscience (29-02-2016)“…It is well established that the endothelium responds to mechanical forces induced by changes in shear stress and strain. However, our understanding of vascular…”
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Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury
Published in Frontiers in neurology (06-06-2019)“…The endothelium is a thin monolayer of specialized cells that lines the luminal wall of blood vessels and constitutes the critical innermost portion of the…”
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Dexamethasone Attenuates the Enhanced Rewarding Effects of Cocaine Following Experimental Traumatic Brain Injury
Published in Cell transplantation (01-07-2017)“…Clinical studies have identified traumatic brain injury (TBI) as a risk factor for the development of cocaine dependence. This claim is supported by our recent…”
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Safety of lung cancer surgery during COVID-19 in a pandemic epicenter
Published in The Journal of thoracic and cardiovascular surgery (01-08-2022)“…The influence of SARS-CoV-2 on surgery for non–small cell lung cancer needs to be understood to inform clinical decision making during and after the COVID-19…”
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Characterization of human fetal brain endothelial cells reveals barrier properties suitable for in vitro modeling of the BBB with syngenic co-cultures
Published in Journal of cerebral blood flow and metabolism (01-05-2018)“…Endothelial cells (ECs) form the basis of the blood–brain barrier (BBB), a physical barrier that selectively restricts transport into the brain. In vitro…”
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Adolescent Traumatic Brain Injury Induces Chronic Mesolimbic Neuroinflammation with Concurrent Enhancement in the Rewarding Effects of Cocaine in Mice during Adulthood
Published in Journal of neurotrauma (01-01-2017)“…Clinical psychiatric disorders of depression, anxiety, and substance abuse are most prevalent after traumatic brain injury (TBI). Pre-clinical research has…”
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The effects of fluid injection on lesion size during bipolar radiofrequency treatment
Published in Regional anesthesia and pain medicine (01-05-2012)“…The effect of preinjected fluid on bipolar radiofrequency (RF) lesion characteristics has not been investigated with conventional pain medicine equipment. The…”
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Trafficking of AAV vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells
Published in Journal of neurochemistry (15-12-2016)“…Developing therapies for central nervous system (CNS) diseases is exceedingly difficult due to the blood-brain barrier (BBB). Notably, emerging technologies…”
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