Search Results - "Lutter, Ferdinand H."

Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets by Lutter, Ferdinand H., Grokenberger, Lucie, Perego, Luca Alessandro, Broggini, Diego, Lemaire, Sébastien, Wagschal, Simon, Knochel, Paul

“…Aryl azole scaffolds are present in a wide range of pharmaceutically relevant molecules. Their ortho-selective metalation at the aryl ring is challenging, due…”
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Hemithioindigos for Cellular Photopharmacology: Desymmetrised Molecular Switch Scaffolds Enabling Design Control over the Isomer‐Dependency of Potent Antimitotic Bioactivity by Sailer, Alexander, Ermer, Franziska, Kraus, Yvonne, Lutter, Ferdinand H., Donau, Carsten, Bremerich, Maximilian, Ahlfeld, Julia, Thorn‐Seshold, Oliver

“…Druglike small molecules with photoswitchable bioactivity—photopharmaceuticals—allow biologists to perform studies with exquisitely precise and reversible,…”
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Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo by Sailer, Alexander, Ermer, Franziska, Kraus, Yvonne, Bingham, Rebekkah, Lutter, Ferdinand H, Ahlfeld, Julia, Thorn-Seshold, Oliver

“…Hemithioindigo is a promising molecular photoswitch that has only recently been applied as a photoswitchable pharmacophore for control over bioactivity in…”
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Facile Conversion of Molecularly Complex (Hetero)aryl Carboxylic Acids into Alkynes for Accelerated SAR Exploration by Lutter, Ferdinand H., Jouffroy, Matthieu

“…1,2,3‐Triazoles are well‐established bioisosteres for amides, often installed as a result of structure−activity‐relationship (SAR) exploration. A…”
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Preparation of Primary and Secondary Dialkylmagnesiums by a Radical I/Mg‐Exchange Reaction Using sBu2Mg in Toluene by Sunagatullina, Alisa S., Lutter, Ferdinand H., Knochel, Paul

“…The treatment of primary or secondary alkyl iodides with sBu2Mg in toluene (25–40 °C, 2–4 h) provided dialkylmagnesiums that underwent various reactions with…”
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Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives by Lutter, Ferdinand H, Grokenberger, Lucie, Hofmayer, Maximilian S, Knochel, Paul

“…A cobalt-catalyzed acylation reaction of various primary, secondary and tertiary alkyl, benzyl and (hetero)aryl S -pyridyl thioesters with (hetero)arylzinc…”
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Iron‐Catalyzed Radical Zincations of Alkyl Iodides by Sunagatullina, Alisa S., Lutter, Ferdinand H., Karaghiosoff, Konstantin, Knochel, Paul

“…We report a new iron‐catalyzed I/Zn‐exchange allowing to convert primary or tailored secondary alkyl iodides into the corresponding alkylzinc iodides. In the…”
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A Robust and Broadly Applicable Cobalt‐Catalyzed Cross‐Coupling of Functionalized Bench‐Stable Organozinc Pivalates with Unsaturated Halides by Hammann, Jeffrey M., Lutter, Ferdinand H., Haas, Diana, Knochel, Paul

“…We report a robust and broadly applicable CoCl2‐catalyzed cross‐coupling between functionalized aryl and heteroaryl zinc pivalates and various electron‐poor…”
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Cobalt‐Catalyzed Cross‐Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides by Lutter, Ferdinand H., Grokenberger, Lucie, Spieß, Philipp, Hammann, Jeffrey M., Karaghiosoff, Konstantin, Knochel, Paul

“…A combination of 10 % CoCl2 and 20 % 2,2′‐bipyridine ligands enables cross‐coupling of functionalized primary and secondary alkylzinc reagents with various…”
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Mild Cobalt-Catalyzed Negishi Cross-Couplings of (Hetero)arylzinc Reagents with (Hetero)aryl Halides by Haas, Diana, Hammann, Jeffrey M., Lutter, Ferdinand H., Knochel, Paul

“…A catalytic system consisting of CoCl2⋅2 LiCl (5 mol %) and HCO2Na (50 mol %) enables the cross‐coupling of various N‐heterocyclic chlorides and bromides as…”
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Cobalt-Catalyzed Diastereoselective Cross-Couplings between Alkynylzinc Pivalates and Functionalized Cyclic Iodides or Bromides by Thomas, Lucie, Lutter, Ferdinand H, Hofmayer, Maximilian S, Karaghiosoff, Konstantin, Knochel, Paul

“…Various 1,2-, 1,3-, and 1,4-substituted cyclic iodides or bromides undergo highly diastereoselective cross-couplings (diastereoselectivity (dr) up to 99:1)…”
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Cobalt-Catalyzed Csp 3 -Csp 3 Cross-Coupling of Functionalized Alkylzinc Reagents with Alkyl Iodides by Lutter, Ferdinand H, Grokenberger, Lucie, Benz, Maximilian, Knochel, Paul

“…A mild cobalt-catalyzed Negishi-type cross-coupling of various functionalized dialkylzinc reagents with primary and secondary alkyl iodides in acetonitrile is…”
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Practical Ni-Catalyzed Cross-Coupling of Unsaturated Zinc Pivalates with Unsaturated Nonaflates and Triflates by Hofmayer, Maximilian S, Lutter, Ferdinand H, Grokenberger, Lucie, Hammann, Jeffrey M, Knochel, Paul

“…A practical nickel-catalyzed cross-coupling of (hetero)­aryl or alkynylzinc pivalates with various unsaturated nonaflates or triflates is described. Organozinc…”
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Cobalt‐Catalyzed Cross‐Couplings and Electrophilic Aminations using Organozinc Pivalates by Lutter, Ferdinand H., Graßl, Simon, Grokenberger, Lucie, Hofmayer, Maximilian S., Chen, Yi‐Hung, Knochel, Paul

“…Transition metal catalyzed cross‐couplings are essential methods in organic synthesis. Due to their comparable low toxicity and price, cobalt‐salts offer a…”
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Directed regioselective ortho,ortho′-magnesiations of aromatics and heterocycles using sBu2Mg in toluene by Hess, Andreas, Prohaska, Jan P, Doerrich, Sabrina B, Trauner, Florian, Lutter, Ferdinand H, Lemaire, Sébastien, Wagschal, Simon, Karaghiosoff, Konstantin, Knochel, Paul

“…Aryl azoles are ubiquitous as bioactive compounds and their regioselective functionalization is of utmost synthetic importance. Here, we report the development…”
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Herstellung von primären und sekundären Dialkylmagnesiumverbindungen durch eine radikalische I/Mg‐Austauschreaktion mit sBu2Mg in Toluol by Sunagatullina, Alisa S., Lutter, Ferdinand H., Knochel, Paul

“…Die Behandlung von primären oder sekundären Alkyliodiden mit sBu2Mg in Toluol (25–40 °C, 2–4 h) lieferte Dialkylmagnesiumverbindungen, die verschiedene…”
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Cobalt‐Catalyzed Cross‐Couplings and Electrophilic Aminations using Organozinc Pivalates by Lutter, Ferdinand H., Graßl, Simon, Grokenberger, Lucie, Hofmayer, Maximilian S., Chen, Yi‐Hung, Knochel, Paul

“…The front cover artwork for Issue 21/2019 is provided by researchers from Ludwig‐Maximilians‐Universität (Germany) and Wuhan University (China). The image…”
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Tailoring the Energetic Properties of 5-(5-Amino-1,2,3-triazol-4-yl)tetraz­ole and Its Derivatives by Salt Formation: From Sensitive Primary to Insensitive Secondary Explosives by Izsák, Dániel, Klapötke, Thomas M., Lutter, Ferdinand H., Pflüger, Carolin

“…The main challenge in the development of energetic materials is the combination of high energy content with chemical and mechanical stability, two properties…”
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Cobalt‐katalysierte Kreuzkupplung funktionalisierter Alkylzinkreagenzien mit (Hetero‐)Arylhalogeniden by Lutter, Ferdinand H., Grokenberger, Lucie, Spieß, Philipp, Hammann, Jeffrey M., Karaghiosoff, Konstantin, Knochel, Paul

“…Eine Kombination aus 10 % CoCl2 und 20 % 2,2′‐Bipyridin als Liganden ermöglicht die Kreuzkupplung von funktionalisierten primären und sekundären…”
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A Robust and Broadly Applicable Cobalt‐Catalyzed Cross‐Coupling of Functionalized Bench‐Stable Organozinc Pivalates with Unsaturated Halides by Hammann, Jeffrey M., Lutter, Ferdinand H., Haas, Diana, Knochel, Paul

“…We report a robust and broadly applicable CoCl2‐catalyzed cross‐coupling between functionalized aryl and heteroaryl zinc pivalates and various electron‐poor…”
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