Search Results - "Lutolf, M."

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering by Hubbell, J A, Lutolf, M P

“…New generations of synthetic biomaterials are being developed at a rapid pace for use as three-dimensional extracellular microenvironments to mimic the…”
Get full text

Extracellular matrix requirements for gastrointestinal organoid cultures by Rezakhani, S., Gjorevski, N., Lutolf, M.P.

“…Organoids are a new class of biological model systems that have garnered significant interest in the life sciences. When provided with the proper 3D matrix and…”
Get full text

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture by Gilbert, P.M, Havenstrite, K.L, Magnusson, K.E.G, Sacco, A, Leonardi, N.A, Kraft, P, Nguyen, N.K, Thrun, S, Lutolf, M.P, Blau, H.M

“…Stem cells that naturally reside in adult tissues, such as muscle stem cells (MuSCs), exhibit robust regenerative capacity in vivo that is rapidly lost in…”
Get full text

Tissue geometry drives deterministic organoid patterning by Gjorevski, N, Nikolaev, M, Brown, T E, Mitrofanova, O, Brandenberg, N, DelRio, F W, Yavitt, F M, Liberali, P, Anseth, K S, Lutolf, M P

“…Epithelial organoids are stem cell–derived tissues that approximate aspects of real organs, and thus they have potential as powerful tools in basic and…”
Get full text

Hydrogel microfluidics for the patterning of pluripotent stem cells by Cosson, S., Lutolf, M. P.

“…Biomolecular signaling is of utmost importance in governing many biological processes such as the patterning of the developing embryo where biomolecules…”
Get full text

3D niche microarrays for systems-level analyses of cell fate by Ranga, A., Gobaa, S., Okawa, Y., Mosiewicz, K., Negro, A., Lutolf, M. P.

“…The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D) microenvironment and involves a dynamic interplay between biochemical…”
Get full text

Hydrogel-based milliwell arrays for standardized and scalable retinal organoid cultures by Decembrini, S., Hoehnel, S., Brandenberg, N., Arsenijevic, Y., Lutolf, M. P.

“…The development of improved methods to culture retinal organoids is relevant for the investigation of mechanisms of retinal development under…”
Get full text

Synthesis and Physicochemical Characterization of End-Linked Poly(ethylene glycol)-co-peptide Hydrogels Formed by Michael-Type Addition by Lutolf, M. P., Hubbell, J. A.

“…The synthesis of novel hybrid hydrogels by stepwise copolymerization of multiarm vinyl sulfone-terminated poly(ethylene glycol) macromers and α−ω cysteine…”
Get full text

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling by Ehrbar, M., Sala, A., Lienemann, P., Ranga, A., Mosiewicz, K., Bittermann, A., Rizzi, S.C., Weber, F.E., Lutolf, M.P.

“…Reductionist in vitro model systems which mimic specific extracellular matrix functions in a highly controlled manner, termed artificial extracellular matrices…”
Get full text

Molecularly Engineered PEG Hydrogels: A Novel Model System for Proteolytically Mediated Cell Migration by Raeber, G.P., Lutolf, M.P., Hubbell, J.A.

“…Model systems mimicking the extracellular matrix (ECM) have greatly helped in quantifying cell migration in three dimensions and elucidated the molecular…”
Get full text

Capturing Cell–Cell Interactions via SNAP-tag and CLIP-tag Technology by Hoehnel, S, Lutolf, M. P

“…Juxtacrine or contact-dependent signaling is a major form of cell communication in multicellular organisms. The involved cell–cell and…”
Get full text

Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics by Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., Hubbell, J. A.

“…Synthetic hydrogels have been molecularly engineered to mimic the invasive characteristics of native provisional extracellular matrices: a combination of…”
Get full text

Systematic Modulation of Michael-Type Reactivity of Thiols through the Use of Charged Amino Acids by Lutolf, M. P, Tirelli, N, Cerritelli, S, Cavalli, L, Hubbell, J. A

“…A quantitative structure−reactivity relationship for the Michael-type addition of thiols onto acrylates was determined. Several thiol-containing peptides were…”
Get full text

Microfluidic Programming of Compositional Hydrogel Landscapes by Allazetta, S., Negro, A., Lutolf, M. P.

“…A droplet microfluidics strategy to rapidly synthesize, process, and screen up to hundreds of thousands of compositionally distinct synthetic hydrogels is…”
Get full text

Genetic pathways to glioblastoma: A population-based study by OHGAKI, Hiroko, DESSEN, Pierre, BAEZA, Nathalie, PISANI, Paola, YONEKAWA, Yasuhiro, YASARGIL, M. Gazi, LÜTOLF, Urs M, KLEIHUES, Paul, JOURDE, Benjamin, HORSTMANN, Sonja, NISHIKAWA, Tomofumi, DI PATRE, Pier-Luigi, BURKHARD, Christoph, SCHÜLER, Danielle, PROBST-HENSCH, Nicole M, MAIORKA, Paulo César

“…We conducted a population-based study on glioblastomas in the Canton of Zurich, Switzerland (population, 1.16 million) to determine the frequency of major…”
Get full text

Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues by Gobaa, S, Hoehnel, S, Lutolf, M P

“…Fate choices of stem cells are regulated in response to a complex array of biochemical and physical signals from their microenvironmental niche. Whereas the…”
Get full text

MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing by Seliktar, D., Zisch, A. H., Lutolf, M. P., Wrana, J. L., Hubbell, J. A.

“…We sought to develop bioactive hydrogels to facilitate arterial healing, e.g., after balloon angioplasty. Toward this end, we developed a new class of…”
Get full text

Microfluidic production of bioactive fibrin micro-beads embedded in crosslinked collagen used as an injectable bulking agent for urinary incontinence treatment by Vardar, E., Larsson, H.M., Allazetta, S., Engelhardt, E.M., Pinnagoda, K., Vythilingam, G., Hubbell, J.A., Lutolf, M.P., Frey, P.

“…[Display omitted] Endoscopic injection of bulking agents has been widely used to treat urinary incontinence, often due to urethral sphincter complex…”
Get full text

A bioactive injectable bulking material; a potential therapeutic approach for stress urinary incontinence by Vardar, E., Vythilingam, G., Pinnagoda, K., Engelhardt, E.M., Zambelli, P.Y., Hubbell, J.A., Lutolf, M.P., Frey, P., Larsson, H.M.

“…Stress urinary incontinence (SUI) is a life changing condition, affecting 20 million women worldwide. In this study, we developed a bioactive, injectable…”
Get full text

The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptides by Fittkau, M.H, Zilla, P, Bezuidenhout, D, Lutolf, M.P, Human, P, Hubbell, J.A, Davies, N

“…The ability of the biomimetic peptides YIGSR, PHSRN and RGD to selectively affect adhesion and migration of human microvascular endothelial cells (MVEC) and…”
Get full text