Search Results - "Lutkewitte, Andrew J"

Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity by Lutkewitte, Andrew J, Finck, Brian N

“…Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis pathway that has incredibly important structural functions as a…”
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Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans by Liss, Kim H.H., Lutkewitte, Andrew J., Pietka, Terri, Finck, Brian N., Franczyk, Michael, Yoshino, Jun, Klein, Samuel, Hall, Angela M.

“…Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has…”
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Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism by Ferguson, Daniel, Eichler, Sophie J., Yiew, Nicole K.H., Colca, Jerry R., Cho, Kevin, Patti, Gary J., Shew, Trevor M., Lutkewitte, Andrew J., Mukherjee, Sandip, McCommis, Kyle S., Niemi, Natalie M., Finck, Brian N.

“…The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis…”
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Hepatic monoacylglycerol acyltransferase 1 is induced by prolonged food deprivation to modulate the hepatic fasting response[S] by Lutkewitte, Andrew J., McCommis, Kyle S., Schweitzer, George G., Chambers, Kari T., Graham, Mark J., Wang, Lingjue, Patti, Gary J., Hall, Angela M., Finck, Brian N.

“…During prolonged fasting, the liver plays a central role in maintaining systemic energy homeostasis by producing glucose and ketones in processes fueled by…”
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Glucolipotoxic Stress-Induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death by Chen, Yi-Chun, Lutkewitte, Andrew J, Basavarajappa, Halesha D, Fueger, Patrick T

“…A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and…”
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Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1 by Lutkewitte, Andrew J., Singer, Jason M., Shew, Trevor M., Martino, Michael R., Hall, Angela M., He, Mai, Finck, Brian N.

“…Monoacylglycerol acyltransferase (MGAT) enzymes catalyze the synthesis of diacylglycerol from monoacylglycerol. Previous work has suggested the importance of…”
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VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism by Kumari, Roshan, Ponte, Michael E., Franczak, Edziu, Prom, John C., O'Neil, Maura F., Sardiu, Mihaela E., Lutkewitte, Andrew J., Christenson, Lane K., Shankar, Kartik, Morris, E. Matthew, Thyfault, John P.

“…Menopause adversely impacts systemic energy metabolism and increases the risk of metabolic disease(s) including hepatic steatosis, but the mechanisms are…”
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Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo by Mukherjee, Sandip, Chakraborty, Molee, Msengi, Eliwaza N., Haubner, Jake, Zhang, Jinsong, Jellinek, Matthew J., Carlson, Haley L., Pyles, Kelly, Ulmasov, Barbara, Lutkewitte, Andrew J., Carpenter, Danielle, McCommis, Kyle S., Ford, David A., Finck, Brian N., Neuschwander-Tetri, Brent A., Chakraborty, Anutosh

“…Defining the regulators of cell metabolism and signaling is essential to design new therapeutic strategies in obesity and NAFLD/NASH. E3 ubiquitin ligases…”
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Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice by Yiew, Nicole K.H., Deja, Stanislaw, Ferguson, Daniel, Cho, Kevin, Jarasvaraparn, Chaowapong, Jacome-Sosa, Miriam, Lutkewitte, Andrew J., Mukherjee, Sandip, Fu, Xiaorong, Singer, Jason M., Patti, Gary J., Burgess, Shawn C., Finck, Brian N.

“…The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing…”
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301-OR: Lipin 1–Mediated Phosphatidic Acid Phosphatase Activity in Adipocytes Regulates Systemic Insulin Sensitivity on High-Fat Diet by LUTKEWITTE, ANDREW J., FINCK, BRIAN N.

“…Emerging evidence suggests that the capacity of adipocytes to appropriately store lipids and prevent their ectopic accumulation in liver and skeletal muscle…”
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Fatty Acid Desaturation Gets a NAD+ Reputation by Lutkewitte, Andrew J., Burgess, Shawn C., Finck, Brian N.

“…delta-5 desaturase and delta-6 desaturase are enzymes known to be involved in the synthesis of highly unsaturated fatty acids. In this issue, Kim et al. (2019)…”
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1575-P: Glycerol Metabolism and Gluconeogenesis in Mice Lacking the Mitochondrial Pyruvate Carrier in Hepatocytes by YIEW, NICOLE, FERGUSON, DANIEL, CHO, KEVIN, DEJA, STANISLAW, JARASVARAPARN, CHAOWAPONG, FU, XIAORONG, LUTKEWITTE, ANDREW J., MUKHERJEE, SANDIP, SINGER, JASON M., PATTI, GARY J., BURGESS, SHAWN C., FINCK, BRIAN N.

“…Hepatic glucose production from glycogen breakdown and gluconeogenic substrates is an important physiologic adaptation, but uncontrolled glucose release by the…”
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Monoacylglycerol O‐acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice by Singer, Jason M., Shew, Trevor M., Ferguson, Daniel, Renkemeyer, M. Katie, Pietka, Terri A., Hall, Angela M., Finck, Brian N., Lutkewitte, Andrew J.

“…Objective Monoacylglycerol O‐acyltransferase 1 (Mogat1), a lipogenic enzyme that converts monoacylglycerol to diacylglycerol, is highly expressed in adipocytes…”
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Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z by Rudnick, David A., Huang, Jiansheng, Hidvegi, Tunda, Chu, Andrew S., Hale, Pamela, Munanairi, Admire, Dietzen, Dennis J., Cliften, Paul F., Tycksen, Eric, Lutkewitte, Andrew J., Finck, Brian N., Pak, Stephen C., Silverman, Gary A., Perlmutter, David H.

“…Insulin signaling is known to regulate essential proteostasis mechanisms. The analyses here examined effects of insulin signaling in the PiZ mouse model of…”
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Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids by Martino, Michael R., Gutiérrez-Aguilar, Manuel, Yiew, Nicole K.H., Lutkewitte, Andrew J., Singer, Jason M., McCommis, Kyle S., Ferguson, Daniel, Liss, Kim H.H., Yoshino, Jun, Renkemeyer, M. Katie, Smith, Gordon I., Cho, Kevin, Fletcher, Justin A., Klein, Samuel, Patti, Gary J., Burgess, Shawn C., Finck, Brian N.

“…Hepatic gluconeogenesis from amino acids contributes significantly to diabetic hyperglycemia, but the molecular mechanisms involved are incompletely…”
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Monoacylglycerol Acyltransferase 1 Knockdown Exacerbates Hepatic Ischemia/Reperfusion Injury in Mice With Hepatic Steatosis by Liss, Kim H. H., Ek, Shelby E., Lutkewitte, Andrew J., Pietka, Terri A., He, Mai, Skaria, Priya, Tycksen, Eric, Ferguson, Daniel, Blanc, Valerie, Graham, Mark J., Hall, Angela M., McGill, Mitchell R., McCommis, Kyle S., Finck, Brian N.

“…Nonalcoholic fatty liver disease (NAFLD) is becoming the most common indication for liver transplantation. The growing prevalence of NAFLD not only increases…”
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Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration by Lutkewitte, Andrew J., Schweitzer, George G., Kennon-McGill, Stefanie, Clemens, Melissa M., James, Laura P., Jaeschke, Hartmut, Finck, Brian N., McGill, Mitchell R.

“…•Phosphatidic acid increases in liver and circulation in mice after APAP overdose.•Phosphatidic acid increases in circulation of humans with APAP…”
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Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids by Martino, Michael R., Gutiérrez-Aguilar, Manuel, Yiew, Nicole K.H., Lutkewitte, Andrew J., Singer, Jason M., McCommis, Kyle S., Ferguson, Daniel, Liss, Kim H.H., Yoshino, Jun, Renkemeyer, M. Katie, Smith, Gordon I., Cho, Kevin, Fletcher, Justin A., Klein, Samuel, Patti, Gary J., Burgess, Shawn C., Finck, Brian N.

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Impact of Hepatic Mig6 on Glucose Homeostasis and Oxidative Stress by IRIMIA-DOMINGUEZ, JOSE M., LUTKEWITTE, ANDREW J., FUEGER, PATRICK T.

“…Hepatic epidermal growth factor receptor (EGFR) expression and activation are decreased during steatosis in humans and several animal models of obesity…”
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Monoacylglycerol O-acyltransferase 1 Lowers Adipocyte Differentiation Capacity in Vitro but Does Not Affect Adiposity in Mice by Singer, Jason M, Shew, Trevor M, Ferguson, Daniel, Renkemeyer, M Katie, Pietka, Terri A, Hall, Angela M, Finck, Brian N, Lutkewitte, Andrew J

“…Objective: Monoacylglycerol O-acyltransferase 1 (Mogatl), a lipogenic enzyme that converts monoacylglycerol to diacylglycerol, is highly expressed in…”
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