Search Results - "Luthman, Adam"

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining by Pryor, John M, Conlin, Michael P, Carvajal-Garcia, Juan, Luedeman, Megan E, Luthman, Adam J, Small, George W, Ramsden, Dale A

“…The nonhomologous end-joining (NHEJ) pathway preserves genome stability by ligating the ends of broken chromosomes together. It employs end-processing enzymes,…”
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Templated insertions—DNA repair gets acrobatic by Stroik, Susanna, Luthman, Adam J., Ramsden, Dale A.

“…Deletions associated with the repair of DNA double‐strand breaks is a source of genetic alternation and a recognized source of disease‐causing mutagenesis…”
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Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection by Luedeman, Megan E., Stroik, Susanna, Feng, Wanjuan, Luthman, Adam J., Gupta, Gaorav P., Ramsden, Dale A.

“…The DNA polymerase theta (Polθ)-mediated end joining (TMEJ) pathway for repair of chromosomal double strand breaks (DSBs) is essential in cells deficient in…”
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Homologous Recombination in Protozoan Parasites and Recombinase Inhibitors by Kelso, Andrew A, Waldvogel, Sarah M, Luthman, Adam J, Sehorn, Michael G

“…Homologous recombination (HR) is a DNA double-strand break (DSB) repair pathway that utilizes a homologous template to fully repair the damaged DNA. HR is…”
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Stepwise requirements for polymerases δ and θ in theta-mediated end joining by Stroik, Susanna, Carvajal-Garcia, Juan, Gupta, Dipika, Edwards, Alyssa, Luthman, Adam, Wyatt, David W., Dannenberg, Rachel L., Feng, Wanjuan, Kunkel, Thomas A., Gupta, Gaorav P., Hedglin, Mark, Wood, Richard, Doublié, Sylvie, Rothenberg, Eli, Ramsden, Dale A.

“…Timely repair of chromosomal double-strand breaks is required for genome integrity and cellular viability. The polymerase theta-mediated end joining pathway…”
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Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency by Kumar, Rashmi J, Chao, Hui Xiao, Simpson, Dennis A, Feng, Wanjuan, Cho, Min-Guk, Roberts, Victoria R, Sullivan, Aurora R, Shah, Sonam J, Wozny, Anne-Sophie, Fagan-Solis, Katerina, Kumar, Sunil, Luthman, Adam, Ramsden, Dale A, Purvis, Jeremy E, Gupta, Gaorav P

“… deficiency in cancer is associated with poor patient outcomes and resistance to DNA damaging therapies. However, the mechanisms underlying treatment…”
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