Search Results - "Luthi‐Carter, Ruth"

What have we learned from gene expression profiles in Huntington's disease? by Seredenina, Tamara, Luthi-Carter, Ruth

“…Abstract The availability of many high-quality genome-wide expression datasets has provided an exciting and unique opportunity to better understand the…”
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Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease by Guidetti, Paolo, Luthi-Carter, Ruth E., Augood, Sarah J., Schwarcz, Robert

“…Huntington's disease (HD), an inherited neurodegenerative disorder, is caused by an abnormal polyglutamine expansion in the huntingtin protein. This genetic…”
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MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms by Jovicic, Ana, Zaldivar Jolissaint, Julien Francisco, Moser, Roger, Silva Santos, Mariana de Fatima, Luthi-Carter, Ruth

“…Whereas many causes and mechanisms of neurodegenerative diseases have been identified, very few therapeutic strategies have emerged in parallel. One possible…”
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Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain by Kuhn, Alexandre, Thu, Doris, Waldvogel, Henry J, Faull, Richard L M, Luthi-Carter, Ruth

“…A computational approach for analysis of gene expression in heterogeneous samples of varying composition is presented. The authors used it to study expression…”
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The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases by Smith, Ruben, Capotosti, Francesca, Schain, Martin, Ohlsson, Tomas, Vokali, Efthymia, Molette, Jerome, Touilloux, Tanja, Hliva, Valerie, Dimitrakopoulos, Ioannis K., Puschmann, Andreas, Jögi, Jonas, Svenningsson, Per, Andréasson, Mattias, Sandiego, Christine, Russell, David S., Miranda-Azpiazu, Patricia, Halldin, Christer, Stomrud, Erik, Hall, Sara, Bratteby, Klas, Tampio L’Estrade, Elina, Luthi-Carter, Ruth, Pfeifer, Andrea, Kosco-Vilbois, Marie, Streffer, Johannes, Hansson, Oskar

“…A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately the treatment of α-synuclein-related…”
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Sustained effects of nonallele-specific Huntingtin silencing by Drouet, Valérie, Perrin, Valérie, Hassig, Raymonde, Dufour, Noëlle, Auregan, Gwennaelle, Alves, Sandro, Bonvento, Gilles, Brouillet, Emmanuel, Luthi-Carter, Ruth, Hantraye, Philippe, Déglon, Nicole

“…Objective Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt)…”
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Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease by Labbadia, John, Cunliffe, Helen, Weiss, Andreas, Katsyuba, Elena, Sathasivam, Kirupa, Seredenina, Tamara, Woodman, Ben, Moussaoui, Saliha, Frentzel, Stefan, Luthi-Carter, Ruth, Paganetti, Paolo, Bates, Gillian P

“…Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. Previous studies have proposed that…”
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Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation by Seredenina, Tamara, Gokce, Ozgun, Luthi-Carter, Ruth

“…The molecular phenotype of Huntington's disease (HD) is known to comprise highly reproducible changes in gene expression involving striatal signaling genes…”
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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets by Jiang, Mali, Wang, Jiawei, Fu, Jinrong, Du, Lin, Jeong, Hyunkyung, West, Tim, Xiang, Lan, Peng, Qi, Hou, Zhipeng, Cai, Huan, Seredenina, Tamara, Arbez, Nicolas, Zhu, Shanshan, Sommers, Katherine, Qian, Jennifer, Zhang, Jiangyang, Mori, Susumu, Yang, X William, Tamashiro, Kellie L K, Aja, Susan, Moran, Timothy H, Luthi-Carter, Ruth, Martin, Bronwen, Maudsley, Stuart, Mattson, Mark P, Cichewicz, Robert H, Ross, Christopher A, Holtzman, David M, Krainc, Dimitri, Duan, Wenzhen

“…Huntington's disease is a neurodegenerative disease caused by the accumulation of mutant htt protein. Now, two groups led by Dimitri Krainc and Wenzhen Duan…”
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HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration by Mielcarek, Michal, Landles, Christian, Weiss, Andreas, Bradaia, Amyaouch, Seredenina, Tamara, Inuabasi, Linda, Osborne, Georgina F, Wadel, Kristian, Touller, Chrystelle, Butler, Rachel, Robertson, Janette, Franklin, Sophie A, Smith, Donna L, Park, Larry, Marks, Paul A, Wanker, Erich E, Olson, Eric N, Luthi-Carter, Ruth, van der Putten, Herman, Beaumont, Vahri, Bates, Gillian P

“…Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular…”
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SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis by Luthi-Carter, Ruth, Taylor, David M, Pallos, Judit, Lambert, Emmanuel, Amore, Allison, Parker, Alex, Moffitt, Hilary, Smith, Donna L, Runne, Heike, Gokce, Ozgun, Kuhn, Alexandre, Xiang, Zhongmin, Maxwell, Michele M, Reeves, Steven A, Bates, Gillian P, Neri, Christian, Thompson, Leslie M, Marsh, J. Lawrence, Kazantsev, Aleksey G

“…Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal…”
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Tubulin and Tubulin Posttranslational Modifications in Alzheimer's Disease and Vascular Dementia by Santiago-Mujika, Estibaliz, Luthi-Carter, Ruth, Giorgini, Flaviano, Kalaria, Raj N, Mukaetova-Ladinska, Elizabeta B

“…Alzheimer's disease (AD) and vascular dementia (VaD) are the two most common forms of dementia in older people. Although these two dementia types differ in…”
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Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data by Jones, Lesley, Goldstein, Darlene R, Hughes, Gareth, Strand, Andrew D, Collin, Francois, Dunnett, Stephen B, Kooperberg, Charles, Aragaki, Aaron, Olson, James M, Augood, Sarah J, Faull, Richard L M, Luthi-Carter, Ruth, Moskvina, Valentina, Hodges, Angela K

“…Gene expression microarray experiments are expensive to conduct and guidelines for acceptable quality control at intermediate steps before and after the…”
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Author Correction: Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols by Luthi-Carter, Ruth, Cappelli, Sara, Le Roux-Bourdieu, Morgan, Tentillier, Noemie, Quinn, James P., Petrozziello, Tiziana, Gopalakrishnan, Lathika, Sethi, Purva, Choudhary, Himanshi, Bartolini, Giorgia, Gebara, Elias, Stuani, Cristiana, Font, Laure, An, Jiyan, Ortega, Vanessa, Sage, Jessica, Kosa, Edina, Trombetta, Bianca A., Simeone, Roberto, Seredenina, Tamara, Afroz, Tariq, Berry, James D., Arnold, Steven E., Carlyle, Becky C., Adolfsson, Oskar, Sadri-Vakili, Ghazaleh, Buratti, Emanuele, Bowser, Robert, Agbas, Abdulbaki

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Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols by Luthi-Carter, Ruth, Cappelli, Sara, Le Roux-Bourdieu, Morgan, Tentillier, Noemie, Quinn, James P., Petrozziello, Tiziana, Gopalakrishnan, Lathika, Sethi, Purva, Choudhary, Himanshi, Bartolini, Giorgia, Gebara, Elias, Stuani, Cristiana, Font, Laure, An, Jiyan, Ortega, Vanessa, Sage, Jessica, Kosa, Edina, Trombetta, Bianca A., Simeone, Roberto, Seredenina, Tamara, Afroz, Tariq, Berry, James D., Arnold, Steven E., Carlyle, Becky C., Adolfsson, Oskar, Sadri-Vakili, Ghazaleh, Buratti, Emanuele, Bowser, Robert, Agbas, Abdulbaki

“…The TAR DNA Binding Protein 43 (TDP-43) has been implicated in the pathogenesis of human neurodegenerative diseases and exhibits hallmark neuropathology in…”
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MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition by Taylor, David M, Moser, Roger, Régulier, Etienne, Breuillaud, Lionel, Dixon, Meredith, Beesen, Ayshe Ana, Elliston, Linda, Silva Santos, Mariana de Fatima, Kim, Jinho, Jones, Lesley, Goldstein, Darlene R, Ferrante, Robert J, Luthi-Carter, Ruth

“…We previously demonstrated that sodium butyrate is neuroprotective in Huntington's disease (HD) mice and that this therapeutic effect is associated with…”
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Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice by Ferrante, Robert J, Kubilus, James K, Lee, Junghee, Ryu, Hoon, Beesen, Ayshe, Zucker, Birgit, Smith, Karen, Kowall, Neil W, Ratan, Rajiv R, Luthi-Carter, Ruth, Hersch, Steven M

“…The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no single specific protein-protein interaction of mutant huntingtin has…”
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Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease by Tang, Bin, Seredenina, Tamara, Coppola, Giovanni, Kuhn, Alexandre, Geschwind, Daniel H, Luthi-Carter, Ruth, Thomas, Elizabeth A

“…Abstract R6/2 transgenic mice with expanded CAG repeats (> 300) have a surprisingly prolonged disease progression and longer lifespan than prototypical parent…”
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Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease by McFarland, Karen N, Das, Sudeshna, Sun, Ting Ting, Leyfer, Dmitri, Xia, Eva, Sangrey, Gavin R, Kuhn, Alexandre, Luthi-Carter, Ruth, Clark, Timothy W, Sadri-Vakili, Ghazaleh, Cha, Jang-Ho J

“…In Huntington's disease (HD; MIM ID #143100), a fatal neurodegenerative disorder, transcriptional dysregulation is a key pathogenic feature. Histone…”
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Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood by Runne, Heike, Kuhn, Alexandre, Wild, Edward J, Pratyaksha, Wirahpati, Kristiansen, Mark, Isaacs, Jeremy D, Régulier, Etienne, Delorenzi, Mauro, Tabrizi, Sarah J, Luthi-Carter, Ruth

“…Highly quantitative biomarkers of neurodegenerative disease remain an important need in the urgent quest for disease-modifying therapies. For Huntington's…”
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