Search Results - "Luthi, J"

Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma by Jensen, Samuel A, Day, Emily S, Ko, Caroline H, Hurley, Lisa A, Luciano, Janina P, Kouri, Fotini M, Merkel, Timothy J, Luthi, Andrea J, Patel, Pinal C, Cutler, Joshua I, Daniel, Weston L, Scott, Alexander W, Rotz, Matthew W, Meade, Thomas J, Giljohann, David A, Mirkin, Chad A, Stegh, Alexander H

“…Glioblastoma multiforme (GBM) is a neurologically debilitating disease that culminates in death 14 to 16 months after diagnosis. An incomplete understanding of…”
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Biomimetic, synthetic HDL nanostructures for lymphoma by Yang, Shuo, Damlano, Marina G., Zhang, Heng, Tripathy, Sushant, Luthi, Andrea J., Rink, Jonathan S., Ugolkov, Andrey V., Singh, Amareshwar T. K., Dave, Sandeep S., Gordon, Leo I., Thaxton, C. Shad

“…New therapies that challenge existing paradigms are needed for the treatment of cancer. We report a nanoparticle-enabled therapeutic approach to B-cell…”
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Biomimetic High Density Lipoprotein Nanoparticles For Nucleic Acid Delivery by McMahon, Kaylin M, Mutharasan, R. Kannan, Tripathy, Sushant, Veliceasa, Dorina, Bobeica, Mariana, Shumaker, Dale K, Luthi, Andrea J, Helfand, Brian T, Ardehali, Hossein, Mirkin, Chad A, Volpert, Olga, Thaxton, C. Shad

“…We report a gold nanoparticle-templated high density lipoprotein (HDL AuNP) platform for gene therapy that combines lipid-based nucleic acid transfection…”
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Carfilzomib and the cardiorenal system in myeloma: an endothelial effect? by Rosenthal, A, Luthi, J, Belohlavek, M, Kortüm, K M, Mookadam, F, Mayo, A, Fonseca, R, Bergsagel, P L, Reeder, C B, Mikhael, J R, Stewart, A K

“…Carfilzomib (Cfz) has been associated with an ~5% incidence of unexplained and unpredictable cardiovascular toxicity in clinical trials. We therefore…”
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Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein by Luthi, Andrea J., Lyssenko, Nicholas N., Quach, Duyen, McMahon, Kaylin M., Millar, John S., Vickers, Kasey C., Rader, Daniel J., Phillips, Michael C., Mirkin, Chad A., Thaxton, C.Shad

“…The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL…”
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Cooperation under predation risk: experiments on costs and benefits by Milinski, Manfred, Lüthi, Jean H., Eggler, Rolf, Parker, Geoffrey A.

“…approach hungry pike,…”
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Tailoring of Biomimetic High-Density Lipoprotein Nanostructures Changes Cholesterol Binding and Efflux by Luthi, Andrea J, Zhang, Heng, Kim, Dongwoo, Giljohann, David A, Mirkin, Chad A, Thaxton, C. Shad

“…Gold nanoparticles (Au NPs) were employed as templates to synthesize spherical, high-density lipoprotein (HDL) biomimics (HDL Au NPs) of different sizes and…”
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Bone mineral density in breast cancer patients treated with adjuvant letrozole, tamoxifen, or sequences of letrozole and tamoxifen in the BIG 1-98 study (SAKK 21/07) by Zaman, K., Thürlimann, B., Huober, J., Schönenberger, A., Pagani, O., Lüthi, J., Simcock, M., Giobbie-Hurder, A., Berthod, G., Genton, C., Brauchli, P., Aebi, S.

“…The risk of osteoporosis and fracture influences the selection of adjuvant endocrine therapy. We analyzed bone mineral density (BMD) in Swiss patients of the…”
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Structural changes in skeletal muscle tissue with heavy-resistance exercise by Lüthi, J M, Howald, H, Claassen, H, Rösler, K, Vock, P, Hoppeler, H

“…Muscle strength, muscle cross-sectional area, fiber size, fiber type distribution, capillarity, and mitochondrial volume were estimated before and after 6…”
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Nanotechnology for synthetic high-density lipoproteins by Luthi, Andrea J, Patel, Pinal C, Ko, Caroline H, Mutharasan, R. Kannan, Mirkin, Chad A, Thaxton, C. Shad

“…Atherosclerosis is the disease mechanism responsible for coronary heart disease (CHD), the leading cause of death worldwide. One strategy to combat…”
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Interval matrices for the bottleneck analysis of queueing network models with histogram-based parameters by Luthi, J.

“…Bottleneck analysis using queueing network models is an important technique for the performance analysis and capacity planning of computer and communication…”
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Antibiotic use: is appropriateness expensive? by von Gunten, V, Reymond, J.-P, Boubaker, K, Gerstel, E, Eckert, P, Lüthi, J.-C, Troillet, N

“…Summary Antibiotics are prone to misuse. In this study, 37% of 600 antibiotic prescriptions in three hospitals were considered unnecessary. When antibiotic…”
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Impact of an interdisciplinary strategy on antibiotic use: a prospective controlled study in three hospitals by von Gunten, V., Troillet, N., Beney, J., Boubaker, K., Lüthi, J.-C., Taffé, P., Reymond, J.-P.

“…Objectives: Evaluation of the impact of the implementation of practice guidelines, with or without their reinforcement by a pharmacist, on the intra-hospital…”
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Redimune® NF Liquid, a ready-to-use, high-concentration intravenous immunoglobulin therapy preparation, is safe and typically well tolerated in the routine clinical management of a broad range of conditions by Piguet, D, Tosi, C, Lüthi, J.-M, Andresen, I, Juge, O

“…In clinical practice, intravenous immunoglobulin therapy (IVIG) is used in the management of a wide variety of medical conditions. Observational studies…”
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Readmissions and the quality of care in patients hospitalized with heart failure by Luthi, Jean-Christophe, Lund, Mary Jo, Sampietro-Colom, Laura, Kleinbaum, David G., Ballard, David J., McClellan, William M.

“…Objectives. Clinical practice guidelines based on the results of randomized clinical trials recommend that patients with heart failure due to left ventricular…”
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Studying sensitivities of an EJB performance model by Llado, C.M., Luthi, J.

“…Often, at the time when a performance model is built, some of its input parameters are not known exactly. This can be for a variety of reasons, such as the…”
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Bias in parallel and distributed simulation systems by Kiesling, T., Khayari, R.E.A., Luthi, J.

“…Even after several decades of research, modeling is considered an art, with a high liability to produce incorrect abstractions of real world systems…”
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Outcomes and the quality of care for patients hospitalized with heart failure by Luthi, Jean-Christophe, Flanders, W. Dana, Pitts, Stephen R., Burnand, Bernard, McClellan, William M.

“…Objective. The purpose of this study was to determine whether process quality indicators derived from evidence-based guidelines for heart failure patients were…”
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Performance bounds for distributed systems with workload variabilities and uncertainties by Lüthi, J., Majumdar, S., Kotsis, G., Haring, G.

“…Bounding techniques for queuing network models used to analyze the performance of parallel and distributed computer systems accept single values as model…”
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Evaluation of a population-based prevention program against influenza among Swiss elderly people by Luthi, J-C, Man, F, Ammon, C

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