Search Results - "Luther, Michael A."

Crystal Structures of Recombinant 19-kDa Human Fibroblast Collagenase Complexed to Itself by Lovejoy, Brett, Hassell, Anne M, Luther, Michael A, Weigl, Debra, Jordan, Steven R

“…Collagenase is a member of the matrix metalloproteinase (MMP) family of enzymes. Aberrant regulation of this family has been implicated in pathologies such as…”
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Systems pharmacology and drug repositioning- an integrated approach to metabolic diseases by Luther, Michael A

“…Doc number: A18…”
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Crystal Structures of the Catalytic Domain of Phosphodiesterase 4B Complexed with AMP, 8-Br-AMP, and Rolipram by Xu, Robert X, Rocque, Warren J, Lambert, Millard H, Vanderwall, Dana E, Luther, Michael A, Nolte, Robert T

“…Phosphodiesterase catalyzes the hydrolysis of the intracellular second messenger 3′,5′-cyclic AMP (cAMP) into the corresponding 5′-nucleotide…”
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Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity by Xu, Robert X., Hassell, Anne M., Vanderwall, Dana, Lambert, Millard H., Holmes, William D., Luther, Michael A., Rocque, Warren J., Milburn, Michael V., Zhao, Yingdong, Ke, Hengming, Nolte, Robert T.

“…Cyclic nucleotides are second messengers that are essential in vision, muscle contraction, neurotransmission, exocytosis, cell growth, and differentiation…”
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Phorbol Esters and SDF-1 Induce Rapid Endocytosis and down Modulation of the Chemokine Receptor CXCR4 by Signoret, Natalie, Oldridge, Joanne, Pelchen-Matthews, Annegret, Klasse, Per J., Tran, Thanh, Brass, Lawrence F., Rosenkilde, Mette M., Schwartz, Thue W., Holmes, William, Dallas, Walt, Luther, Michael A., Timothy N. C. Wells, Hoxie, James A., Marsh, Mark

“…The chemokine receptor CXCR4 is required, together with CD4, for entry by some isolates of HIV-1, particularly those that emerge late in infection. The use of…”
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Structure of the Catalytic Domain of Fibroblast Collagenase Complexed with an Inhibitor by Lovejoy, Brett, Cleasby, Anne, Hassell, Anne M., Longley, Kelly, Luthe, Michael A., Weigl, Debra, McGeehan, Gerard, McElroy, Andrew B., Drewry, David, Lambert, Millard H., Jordan, Steven R.

“…Collagenase is a zinc-dependent endoproteinase and is a member of the matrix metalloproteinase (MMP) family of enzymes. The MMPs participate in connective…”
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Thermodynamics of dimer and tetramer formations in rabbit muscle phosphofructokinase by Luther, Michael A, Cai, Guang Zuan, Lee, James C

“…The self-association of rabbit muscle phosphofructokinase (PFK) was monitored as a function of temperature, pH, and ionic strength in order to understand the…”
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Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities by Rocque, Warren J, Tian, Gaochao, Wiseman, Jeffrey S, Holmes, William D, Zajac-Thompson, Irene, Willard, Derril H, Patel, Indravaden R, Wisely, G. Bruce, Clay, William C, Kadwell, Sue H, Hoffman, Christine R, Luther, Michael A

“…The interactions between (R)-rolipram and purified human recombinant low-K m, cAMP-specific phosphodiesterase (HSPDE4B2B) constructs were investigated using…”
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Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding by Rocque, Warren J., Holmes, William D., Patel, Indravadan R., Dougherty, Robert W., Ittoop, Olivia, Overton, Laurie, Hoffman, Christine R., Wisely, G.Bruce, Willard, Derril H., Luther, Michael A.

“…We have overexpressed in a baculovirus expression system, and purified to >95% homogeneity, milligram quantities of a human recombinant rolipram-sensitive cAMP…”
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Dual Inhibition of Human Type 4 Phosphodiesterase Isostates by (R,R)-(±)-Methyl 3-Acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate by Tian, Gaochao, Rocque, Warren J, Wiseman, Jeffrey S, Thompson, Irene Z, Holmes, William D, Domanico, Paul L, Stafford, Jeffrey A, Feldman, Paul L, Luther, Michael A

“…Purified recombinant human type 4 phosphodiesterase B2B (HSPDE4B2B) exists in both a low- and a high-affinity state that bind (R)-rolipram with K d's of ca…”
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Subunit interaction of rabbit muscle phosphofructokinase: effects of purification procedures by Luther, Michael A, Hesterberg, Lyndal K, Lee, James C

“…Structural, physical, and kinetic properties of rabbit muscle phosphofructokinase (PFK) purified by three different procedures were monitored in order to…”
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Self-association of rabbit muscle phosphofructokinase: role of subunit interaction in regulation of enzymic activity by Luther, Michael A, Gilbert, Hiram F, Lee, James C

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Agouti structure and function: characterization of a potent .alpha.-melanocyte stimulating hormone receptor antagonist by Willard, Derril H, Bodnar, Wanda, Harris, Cole, Kiefer, Laura, Nichols, James S, Blanchard, Steven, Hoffman, Christine, Moyer, Mary, Burkhart, William

“…The murine agouti gene encodes for a novel 131 amino acid protein. The sequence includes a 22 residue putative secretion signal, an internal basic region, and…”
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A Soluble, Single-Chain T-Cell Receptor Fragment Endowed with Antigen-Combining Properties by Novotny, Jiri, Ganju, Ramesh K., Smiley, Stephen T., Hussey, Rebecca E., Luther, Michael A., Recny, Michael A., Siliciano, Robert F., Reinherz, Ellis L.

“…A strategy for the production of small, soluble, single-chain T-cell receptor (scTCR) fragments that carry an intact TCR antigen-combining site is presented…”
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Regulation of rabbit muscle phosphofructokinase by phosphorylation by Cai, Guang-Zuan, Callaci, Thomas P., Luther, Michael A., Ching Lee, J.

“…Muscle phosphofructokinase is one of the glycolytic enzymes whose partitioning between the particulate and soluble fractions in skeletal muscle is linked to…”
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Exploration of the Sequence Specificity of pp60 Tyrosine Kinase by Ann M. Edison, Sean C. Barker, Daniel B. Kassel, Michael A. Luther, Wilson B. Knight

“…The minimum length required for phosphorylation of a peptide by pp60 tyrosine kinase ( src TK) was delineated in this work. Budde (M. D. Anderson University of…”
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Exploration of the Sequence Specificity of pp60c-src Tyrosine Kinase by Edison, Ann M., Barker, Sean C., Kassel, Daniel B., Luther, Michael A., Knight, Wilson B.

“…The minimum length required for phosphorylation of a peptide by pp60c-src tyrosine kinase (srcTK) was delineated in this work. Budde (M. D. Anderson University…”
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Exploration of the Sequence Specificity of pp60c- Tyrosine Kinase by Edison, Ann M., Barker, Sean C., Kassel, Daniel B., Luther, Michael A., Knight, Wilson B.

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N-glycosylation is required for human CD2 immunoadhesion functions by RECNY, M. A, LUTHER, M. A, REINHOLD, V. N, REINHERZ, E. L, KNOPPERS, M. H, NEIDHARDT, E. A, KHANDEKAR, S. S, CONCINO, M. F, SCHIMKE, P. A, FRANCIS, M. A, MOEBIUS, U, REINHOLD, B. B

“…The T-lymphocyte glycoprotein receptor, CD2, mediates cell-cell adhesion by binding to the surface molecule CD58 (LFA-3) on many cell types including antigen…”
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Structural analysis of the catalytic domain of human fibroblast collagenase by Lovejoy, B, Cleasby, A, Hassell, A M, Luther, M A, Weigl, D, McGeehan, G, Lambert, M H, Jordan, S R

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