Search Results - "Luther, James M"

Effects of aldosterone on insulin sensitivity and secretion by Luther, James M.

“…•Aldosterone excess is associated with obesity, hypertension, and diabetes.•Renin-angiotensin system antagonists reduce aldosterone concentrations and diabetes…”
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COVID-19 Severity Is Tripled in the Diabetes Community: A Prospective Analysis of the Pandemic's Impact in Type 1 and Type 2 Diabetes by Gregory, Justin M, Slaughter, James C, Duffus, Sara H, Smith, T Jordan, LeStourgeon, Lauren M, Jaser, Sarah S, McCoy, Allison B, Luther, James M, Giovannetti, Erin R, Boeder, Schafer, Pettus, Jeremy H, Moore, Daniel J

“…To quantify and contextualize the risk for coronavirus disease 2019 (COVID-19)-related hospitalization and illness severity in type 1 diabetes. We conducted a…”
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The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis by Luther, James M, Fogo, Agnes B

“…Chronic kidney disease is characterized by progressive scarring that results in loss of normal tissue in the kidney and eventually end-stage kidney disease…”
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Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks by Nanba, Kazutaka, Omata, Kei, Gomez-Sanchez, Celso E, Stratakis, Constantine A, Demidowich, Andrew P, Suzuki, Mari, Thompson, Lester D R, Cohen, Debbie L, Luther, James M, Gellert, Lan, Vaidya, Anand, Barletta, Justine A, Else, Tobias, Giordano, Thomas J, Tomlins, Scott A, Rainey, William E

“…Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent…”
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Primary Aldosteronism Decreases Insulin Secretion and Increases Insulin Clearance in Humans by Adler, Gail K., Murray, Gillian R., Turcu, Adina F., Nian, Hui, Yu, Chang, Solorzano, Carmen C., Manning, Robert, Peng, Dungeng, Luther, James M.

“…Primary aldosteronism is a frequent cause of resistant hypertension and is associated with an increased risk of developing diabetes mellitus. Aldosterone…”
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Effect of the glucagon‐like peptide‐1 receptor agonist liraglutide, compared to caloric restriction, on appetite, dietary intake, body fat distribution and cardiometabolic biomarkers: A randomized trial in adults with obesity and prediabetes by Silver, Heidi J., Olson, Dianna, Mayfield, Dustin, Wright, Patricia, Nian, Hui, Mashayekhi, Mona, Koethe, John R., Niswender, Kevin D., Luther, James M., Brown, Nancy J.

“…Aims To investigate the hypothesis that weight loss with the glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) liraglutide alone would lead to a greater…”
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Targeted Mutational Analysis of Cortisol-Producing Adenomas by Rege, Juilee, Hoxie, Jessie, Liu, Chia-Jen, Cash, Morgan N, Luther, James M, Gellert, Lan, Turcu, Adina F, Else, Tobias, Giordano, Thomas J, Udager, Aaron M, Rainey, William E, Nanba, Kazutaka

“…Somatic gene mutations have been identified in only about half of cortisol-producing adenomas (CPAs). Affected genes include PRKACA, GNAS, PRKAR1A, and CTNNB1…”
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Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT) by Wang, Zhen, Hill, Salisha, Luther, James M., Hachey, David L., Schey, Kevin L.

“…Exosomes are membrane vesicles that are secreted by cells upon fusion of multivesicular bodies with the plasma membrane. Exosomal proteomics has emerged as a…”
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Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion by Qi, Ying, Wang, Xiaojing, Rose, Kristie L, MacDonald, W Hayes, Zhang, Bing, Schey, Kevin L, Luther, James M

“…Urinary exosomes secreted by multiple cell types in the kidney may participate in intercellular signaling and provide an enriched source of kidney-specific…”
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Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone by Brown, Jenifer M, Williams, Jonathan S, Luther, James M, Garg, Rajesh, Garza, Amanda E, Pojoga, Luminita H, Ruan, Daniel T, Williams, Gordon H, Adler, Gail K, Vaidya, Anand

“…Observational studies in primary hyperaldosteronism suggest a positive relationship between aldosterone and parathyroid hormone (PTH); however, interventions…”
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Recalibrating Interpretations of Aldosterone Assays Across the Physiologic Range: Immunoassay and Liquid Chromatography–Tandem Mass Spectrometry Measurements Under Multiple Controlled Conditions by Brown, Jenifer M, Auchus, Richard J, Honzel, Brooke, Luther, James M, Yozamp, Nicholas, Vaidya, Anand

“…Abstract Context Clinicians frequently rely on aldosterone thresholds derived from older immunoassays to diagnose primary aldosteronism. Liquid…”
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Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury by Luther, James M, Luo, Pengcheng, Wang, Zuofei, Cohen, Samuel E, Kim, Hyung-Suk, Fogo, Agnes B, Brown, Nancy J

“…Angiotensin II causes cardiovascular injury in part by aldosterone-induced mineralocorticoid receptor activation, and it can also activate the…”
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Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy by Gangadhariah, Mahesha H, Luther, James M, Garcia, Victor, Paueksakon, Paisit, Zhang, Ming-Zhi, Hayward, Simon W, Love, Harold D, Falck, John R, Manthati, Vijaya L, Imig, John D, Schwartzman, Michal L, Zent, Roy, Capdevila, Jorge H, Pozzi, Ambra

“…In the kidney, 20-hydroxyeicosatetraenoic acid (20-HETE) is a primary cytochrome P450 4 (Cyp4)-derived eicosanoid that enhances vasoconstriction of renal…”
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Retrospective cohort study to characterise the blood pressure response to spironolactone in patients with apparent therapy-resistant hypertension using electronic medical record data by Shuey, Megan, Perkins, Bradley, Nian, Hui, Yu, Chang, Luther, James M, Brown, Nancy

“…ObjectiveIdentify blood pressure (BP) response to spironolactone in patients with apparent therapy-resistant hypertension (aTRH) using electronic medical…”
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Angiotensin II Induces Interleukin-6 in Humans Through a Mineralocorticoid Receptor–Dependent Mechanism by Luther, James M, Gainer, James V, Murphey, Laine J, Yu, Chang, Vaughan, Douglas E, Morrow, Jason D, Brown, Nancy J

“…This study tested the hypothesis that angiotensin promotes oxidative stress and inflammation in humans via aldosterone and the mineralocorticoid receptor. We…”
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Pharmacokinetics of Acyclovir and Its Metabolites in Cerebrospinal Fluid and Systemic Circulation after Administration of High-Dose Valacyclovir in Subjects with Normal and Impaired Renal Function by SMITH, James P, WELLER, Stephen, JOHNSON, Benjamin, NICOTERA, Janet, LUTHER, James M, HAAS, David W

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Unilaterally Successful Adrenal Vein Sampling: Use or Repeat? by Luther, James M., Turcu, Adina F.

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Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors in COVID-19: Meta-analysis/Meta-regression Adjusted for Confounding Factors by Lee, Terry, Cau, Alessandro, Cheng, Matthew Pellan, Levin, Adeera, Lee, Todd C., Vinh, Donald C., Lamontagne, Francois, Singer, Joel, Walley, Keith R., Murthy, Srinivas, Patrick, David, Rewa, Oleksa G., Winston, Brent W., Marshall, John, Boyd, John, Tran, Karen, Kalil, Andre C., Mcculoh, Russell, Fowler, Robert, Luther, James M., Russell, James A.

“…Angiotensin receptor blockers (ARBs) and/or angiotensin-converting enzyme (ACE) inhibitors could alter mortality from coronavirus disease 2019 (COVID-19), but…”
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418 Activation of the Glucagon-Like Peptide-1 Pathway in Obese Pre-Diabetic Individuals Improves Endothelial Function Independently of Weight Loss by Mashayekhi, Mona, Beckman, Joshua A., Garner, Erica M., Nian, Hui, Yu, Chang, Howard, Sara E., Perkins, Bradley, Devin, Jessica K., Koethe, John R., Brown, Jonathan D., Silver, Heidi, Luther, James M., Brown, Nancy J.

“…OBJECTIVES/GOALS: We aimed to determine if GLP-1 receptor agonists exert beneficial effects on surrogate measures of cardiovascular function independently of…”
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Aldosterone in vascular and metabolic dysfunction by Luther, James M

“…PURPOSE OF REVIEWThis review will highlight recent developments in mineralocorticoid receptor research which impact aldosterone-associated vascular and…”
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